Arylvinylpiperazine amides, a new class of potent inhibitors targeting QcrB of Mycobacterium tuberculosis

Arylvinylpiperazine amides, a new class of potent inhibitors targeting QcrB of Mycobacterium tuberculosis

New drugs are needed to control the current tuberculosis (TB) pandemic caused by infection with Mycobacterium tuberculosis. We report here on our work with AX-35, an arylvinylpiperazine amide, and four related analogs, which are potent antitubercular agents in vitro. All five compounds showed good a...

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Bibliographic Details
Main Authors: Foo, Caroline S., Lupien, Andréanne, Kienle, Maryline, Vocat, Anthony, Benjak, Andrej, Sommer, Raphael, Lamprecht, Dirk A., Steyn, Adrie J. C., Pethe, Kevin, Piton, Jérémie, Altmann, Karl-Heinz, Cole, Stewart T.
Other Authors: Nacy, Carol A.
Format: Journal Article
Language:English
Published: 2019
Subjects:
Cytochrome Bc1 Oxidase
QcrB Inhibitor
Science::Medicine
Online Access:https://hdl.handle.net/10356/87647
http://hdl.handle.net/10220/49884

Internet

https://hdl.handle.net/10356/87647
http://hdl.handle.net/10220/49884

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