Precision of Discrete and Rhythmic Forelimb Movements Requires a Distinct Neuronal Subpopulation in the Interposed Anterior Nucleus
The deep cerebellar nuclei (DCN) represent output channels of the cerebellum, and they transmit integrated sensorimotor signals to modulate limb movements. But the functional relevance of identifiable neuronal subpopulations within the DCN remains unclear. Here, we examine a genetically tractable po...
| Main Authors: | , , , , , , , |
|---|---|
| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
| Published: |
2018
|
| Subjects: | |
| Online Access: | https://hdl.handle.net/10356/87995 http://hdl.handle.net/10220/44499 |
| _version_ | 1826122207693111296 |
|---|---|
| author | Low, Aloysius Y. T. Thanawalla, Ayesha Rustom Yip, Alaric K. K. Kim, Jinsook Wong, Kelly L. L. Tantra, Martesa Augustine, George James Chen, Albert I-Ming |
| author2 | Interdisciplinary Graduate School (IGS) |
| author_facet | Interdisciplinary Graduate School (IGS) Low, Aloysius Y. T. Thanawalla, Ayesha Rustom Yip, Alaric K. K. Kim, Jinsook Wong, Kelly L. L. Tantra, Martesa Augustine, George James Chen, Albert I-Ming |
| author_sort | Low, Aloysius Y. T. |
| collection | NTU |
| description | The deep cerebellar nuclei (DCN) represent output channels of the cerebellum, and they transmit integrated sensorimotor signals to modulate limb movements. But the functional relevance of identifiable neuronal subpopulations within the DCN remains unclear. Here, we examine a genetically tractable population of neurons in the mouse interposed anterior nucleus (IntA). We show that these neurons represent a subset of glutamatergic neurons in the IntA and constitute a specific element of an internal feedback circuit within the cerebellar cortex and cerebello-thalamo-cortical pathway associated with limb control. Ablation and optogenetic stimulation of these neurons disrupt efficacy of skilled reach and locomotor movement and reveal that they control positioning and timing of the forelimb and hindlimb. Together, our findings uncover the function of a distinct neuronal subpopulation in the deep cerebellum and delineate the anatomical substrates and kinematic parameters through which it modulates precision of discrete and rhythmic limb movements. |
| first_indexed | 2024-10-01T05:44:43Z |
| format | Journal Article |
| id | ntu-10356/87995 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T05:44:43Z |
| publishDate | 2018 |
| record_format | dspace |
| spelling | ntu-10356/879952020-11-01T04:45:01Z Precision of Discrete and Rhythmic Forelimb Movements Requires a Distinct Neuronal Subpopulation in the Interposed Anterior Nucleus Low, Aloysius Y. T. Thanawalla, Ayesha Rustom Yip, Alaric K. K. Kim, Jinsook Wong, Kelly L. L. Tantra, Martesa Augustine, George James Chen, Albert I-Ming Interdisciplinary Graduate School (IGS) Lee Kong Chian School of Medicine (LKCMedicine) School of Biological Sciences DCN IntA The deep cerebellar nuclei (DCN) represent output channels of the cerebellum, and they transmit integrated sensorimotor signals to modulate limb movements. But the functional relevance of identifiable neuronal subpopulations within the DCN remains unclear. Here, we examine a genetically tractable population of neurons in the mouse interposed anterior nucleus (IntA). We show that these neurons represent a subset of glutamatergic neurons in the IntA and constitute a specific element of an internal feedback circuit within the cerebellar cortex and cerebello-thalamo-cortical pathway associated with limb control. Ablation and optogenetic stimulation of these neurons disrupt efficacy of skilled reach and locomotor movement and reveal that they control positioning and timing of the forelimb and hindlimb. Together, our findings uncover the function of a distinct neuronal subpopulation in the deep cerebellum and delineate the anatomical substrates and kinematic parameters through which it modulates precision of discrete and rhythmic limb movements. ASTAR (Agency for Sci., Tech. and Research, S’pore) MOE (Min. of Education, S’pore) NMRC (Natl Medical Research Council, S’pore) Published version 2018-03-05T05:46:41Z 2019-12-06T16:53:44Z 2018-03-05T05:46:41Z 2019-12-06T16:53:44Z 2018 Journal Article Low, A. Y. T., Thanawalla, A. R., Yip, A. K. K., Kim, J., Wong, K. L. L., Tantra, M., et al. (2018). Precision of Discrete and Rhythmic Forelimb Movements Requires a Distinct Neuronal Subpopulation in the Interposed Anterior Nucleus. Cell Reports, 22(9), 2322-2333. 2211-1247 https://hdl.handle.net/10356/87995 http://hdl.handle.net/10220/44499 10.1016/j.celrep.2018.02.017 en Cell Reports © 2018 The Author(s) (Published by Elsevier). This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). 12 p. application/pdf |
| spellingShingle | DCN IntA Low, Aloysius Y. T. Thanawalla, Ayesha Rustom Yip, Alaric K. K. Kim, Jinsook Wong, Kelly L. L. Tantra, Martesa Augustine, George James Chen, Albert I-Ming Precision of Discrete and Rhythmic Forelimb Movements Requires a Distinct Neuronal Subpopulation in the Interposed Anterior Nucleus |
| title | Precision of Discrete and Rhythmic Forelimb Movements Requires a Distinct Neuronal Subpopulation in the Interposed Anterior Nucleus |
| title_full | Precision of Discrete and Rhythmic Forelimb Movements Requires a Distinct Neuronal Subpopulation in the Interposed Anterior Nucleus |
| title_fullStr | Precision of Discrete and Rhythmic Forelimb Movements Requires a Distinct Neuronal Subpopulation in the Interposed Anterior Nucleus |
| title_full_unstemmed | Precision of Discrete and Rhythmic Forelimb Movements Requires a Distinct Neuronal Subpopulation in the Interposed Anterior Nucleus |
| title_short | Precision of Discrete and Rhythmic Forelimb Movements Requires a Distinct Neuronal Subpopulation in the Interposed Anterior Nucleus |
| title_sort | precision of discrete and rhythmic forelimb movements requires a distinct neuronal subpopulation in the interposed anterior nucleus |
| topic | DCN IntA |
| url | https://hdl.handle.net/10356/87995 http://hdl.handle.net/10220/44499 |
| work_keys_str_mv | AT lowaloysiusyt precisionofdiscreteandrhythmicforelimbmovementsrequiresadistinctneuronalsubpopulationintheinterposedanteriornucleus AT thanawallaayesharustom precisionofdiscreteandrhythmicforelimbmovementsrequiresadistinctneuronalsubpopulationintheinterposedanteriornucleus AT yipalarickk precisionofdiscreteandrhythmicforelimbmovementsrequiresadistinctneuronalsubpopulationintheinterposedanteriornucleus AT kimjinsook precisionofdiscreteandrhythmicforelimbmovementsrequiresadistinctneuronalsubpopulationintheinterposedanteriornucleus AT wongkellyll precisionofdiscreteandrhythmicforelimbmovementsrequiresadistinctneuronalsubpopulationintheinterposedanteriornucleus AT tantramartesa precisionofdiscreteandrhythmicforelimbmovementsrequiresadistinctneuronalsubpopulationintheinterposedanteriornucleus AT augustinegeorgejames precisionofdiscreteandrhythmicforelimbmovementsrequiresadistinctneuronalsubpopulationintheinterposedanteriornucleus AT chenalbertiming precisionofdiscreteandrhythmicforelimbmovementsrequiresadistinctneuronalsubpopulationintheinterposedanteriornucleus |