Solvent and melt based extrusion 3D printing of polycaprolactone bioactive glass composite for tissue engineering
Bioactive glasses are widely used in tissue engineering because of their several unique and interesting characteristics including promoting angiogenesis. In 3D bioprinting, bioactive glasses are added to bio-ink in limited weight percentages to promote bioactivity. In this study, we investigate t...
| Principais autores: | , , , , , |
|---|---|
| Outros Autores: | |
| Formato: | Conference Paper |
| Idioma: | English |
| Publicado em: |
2018
|
| Assuntos: | |
| Acesso em linha: | https://hdl.handle.net/10356/88300 http://hdl.handle.net/10220/45753 |
| _version_ | 1826124679601979392 |
|---|---|
| author | Kolan, Krishna C.R. Li, Wenbin Semon, Julie A. Day, Delbert E. Althage, Rachel Leu, Ming C. |
| author2 | School of Mechanical and Aerospace Engineering |
| author_facet | School of Mechanical and Aerospace Engineering Kolan, Krishna C.R. Li, Wenbin Semon, Julie A. Day, Delbert E. Althage, Rachel Leu, Ming C. |
| author_sort | Kolan, Krishna C.R. |
| collection | NTU |
| description | Bioactive glasses are widely used in tissue engineering because of their several
unique and interesting characteristics including promoting angiogenesis. In 3D bioprinting,
bioactive glasses are added to bio-ink in limited weight percentages to promote bioactivity. In this
study, we investigate two different approaches, solvent-based and melt-based extrusion 3D printing,
to fabricate scaffolds using a bioactive glass contained polymer composite suitable for bioprinting
applications. Highly angiogenic and bioactive borate glass (13-93B3) is added to polycaprolactone
(PCL) in 50 wt.% to prepare the polymer-glass composite. The scaffolds fabricated using the two
approaches are studied for their mechanical properties, degradation, and bioactivity. The scaffold
stiffness and yield strength increased after the addition of borate glass irrespective of the fabrication
approach. Scaffolds were soaked in minimum essential medium for up to four weeks to study weight
loss and bioactivity. The weight loss results indicated a faster borate glass dissolution in scaffolds
made using solvent-based 3D printing whereas an apatite-like layer was formed on scaffolds
fabricated with both approaches. |
| first_indexed | 2024-10-01T06:24:19Z |
| format | Conference Paper |
| id | ntu-10356/88300 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T06:24:19Z |
| publishDate | 2018 |
| record_format | dspace |
| spelling | ntu-10356/883002020-09-24T20:13:10Z Solvent and melt based extrusion 3D printing of polycaprolactone bioactive glass composite for tissue engineering Kolan, Krishna C.R. Li, Wenbin Semon, Julie A. Day, Delbert E. Althage, Rachel Leu, Ming C. School of Mechanical and Aerospace Engineering Proceedings of the 3rd International Conference on Progress in Additive Manufacturing (Pro-AM 2018) Singapore Centre for 3D Printing Bioactive Borate Glass DRNTU::Engineering::Mechanical engineering::Prototyping Polymer Composites Bioactive glasses are widely used in tissue engineering because of their several unique and interesting characteristics including promoting angiogenesis. In 3D bioprinting, bioactive glasses are added to bio-ink in limited weight percentages to promote bioactivity. In this study, we investigate two different approaches, solvent-based and melt-based extrusion 3D printing, to fabricate scaffolds using a bioactive glass contained polymer composite suitable for bioprinting applications. Highly angiogenic and bioactive borate glass (13-93B3) is added to polycaprolactone (PCL) in 50 wt.% to prepare the polymer-glass composite. The scaffolds fabricated using the two approaches are studied for their mechanical properties, degradation, and bioactivity. The scaffold stiffness and yield strength increased after the addition of borate glass irrespective of the fabrication approach. Scaffolds were soaked in minimum essential medium for up to four weeks to study weight loss and bioactivity. The weight loss results indicated a faster borate glass dissolution in scaffolds made using solvent-based 3D printing whereas an apatite-like layer was formed on scaffolds fabricated with both approaches. Published version 2018-08-30T04:32:54Z 2019-12-06T17:00:11Z 2018-08-30T04:32:54Z 2019-12-06T17:00:11Z 2018 Conference Paper Kolan, K. C. R., Li, W., Althage, R., Semon, J. A., Day, D. E., & Leu, M. C. (2018). Solvent and melt based extrusion 3D printing of polycaprolactone bioactive glass composite for tissue engineering. Proceedings of the 3rd International Conference on Progress in Additive Manufacturing (Pro-AM 2018), 176-182. doi:10.25341/D4B018 https://hdl.handle.net/10356/88300 http://hdl.handle.net/10220/45753 10.25341/D4B018 en © 2018 Nanyang Technological University. Published by Nanyang Technological University, Singapore. 7 p. application/pdf |
| spellingShingle | Bioactive Borate Glass DRNTU::Engineering::Mechanical engineering::Prototyping Polymer Composites Kolan, Krishna C.R. Li, Wenbin Semon, Julie A. Day, Delbert E. Althage, Rachel Leu, Ming C. Solvent and melt based extrusion 3D printing of polycaprolactone bioactive glass composite for tissue engineering |
| title | Solvent and melt based extrusion 3D printing of polycaprolactone bioactive glass composite for tissue engineering |
| title_full | Solvent and melt based extrusion 3D printing of polycaprolactone bioactive glass composite for tissue engineering |
| title_fullStr | Solvent and melt based extrusion 3D printing of polycaprolactone bioactive glass composite for tissue engineering |
| title_full_unstemmed | Solvent and melt based extrusion 3D printing of polycaprolactone bioactive glass composite for tissue engineering |
| title_short | Solvent and melt based extrusion 3D printing of polycaprolactone bioactive glass composite for tissue engineering |
| title_sort | solvent and melt based extrusion 3d printing of polycaprolactone bioactive glass composite for tissue engineering |
| topic | Bioactive Borate Glass DRNTU::Engineering::Mechanical engineering::Prototyping Polymer Composites |
| url | https://hdl.handle.net/10356/88300 http://hdl.handle.net/10220/45753 |
| work_keys_str_mv | AT kolankrishnacr solventandmeltbasedextrusion3dprintingofpolycaprolactonebioactiveglasscompositefortissueengineering AT liwenbin solventandmeltbasedextrusion3dprintingofpolycaprolactonebioactiveglasscompositefortissueengineering AT semonjuliea solventandmeltbasedextrusion3dprintingofpolycaprolactonebioactiveglasscompositefortissueengineering AT daydelberte solventandmeltbasedextrusion3dprintingofpolycaprolactonebioactiveglasscompositefortissueengineering AT althagerachel solventandmeltbasedextrusion3dprintingofpolycaprolactonebioactiveglasscompositefortissueengineering AT leumingc solventandmeltbasedextrusion3dprintingofpolycaprolactonebioactiveglasscompositefortissueengineering |