“Locked in a cage”—A case of dengue virus 4 encephalitis
Our patient with DENV-4 infection developed new acute neurological symptoms of confusion and expressive aphasia at day 6 of her acute dengue illness. CSF showed lymphocytic pleocytosis with a positive CSF dengue IgM and IgG. Testing for other pathogens in CSF was negative. She had not travelled to a...
| Main Authors: | , |
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| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
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2018
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| Online Access: | https://hdl.handle.net/10356/88391 http://hdl.handle.net/10220/45723 |
| _version_ | 1826122463737544704 |
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| author | Ng, Deborah H. L. Sadarangani, Sapna P. |
| author2 | Gérardin, Patrick |
| author_facet | Gérardin, Patrick Ng, Deborah H. L. Sadarangani, Sapna P. |
| author_sort | Ng, Deborah H. L. |
| collection | NTU |
| description | Our patient with DENV-4 infection developed new acute neurological symptoms of confusion and expressive aphasia at day 6 of her acute dengue illness. CSF showed lymphocytic pleocytosis with a positive CSF dengue IgM and IgG. Testing for other pathogens in CSF was negative. She had not travelled to areas endemic for other flaviviruses. Although DENV-4 has been reported to potentially cause encephalitis, those cases were fatal, with multiorgan involvement and dengue haemorrhagic fever. [6,7] By contrast, our patient had no other features of severe dengue, such as severe plasma leakage, bleeding, or other organ impairment. This is the first known case of DENV-4 encephalitis with complete recovery. |
| first_indexed | 2024-10-01T05:48:35Z |
| format | Journal Article |
| id | ntu-10356/88391 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T05:48:35Z |
| publishDate | 2018 |
| record_format | dspace |
| spelling | ntu-10356/883912020-11-01T05:21:51Z “Locked in a cage”—A case of dengue virus 4 encephalitis Ng, Deborah H. L. Sadarangani, Sapna P. Gérardin, Patrick Lee Kong Chian School of Medicine (LKCMedicine) Virus Encephalitis Dengue DRNTU::Science::Medicine Our patient with DENV-4 infection developed new acute neurological symptoms of confusion and expressive aphasia at day 6 of her acute dengue illness. CSF showed lymphocytic pleocytosis with a positive CSF dengue IgM and IgG. Testing for other pathogens in CSF was negative. She had not travelled to areas endemic for other flaviviruses. Although DENV-4 has been reported to potentially cause encephalitis, those cases were fatal, with multiorgan involvement and dengue haemorrhagic fever. [6,7] By contrast, our patient had no other features of severe dengue, such as severe plasma leakage, bleeding, or other organ impairment. This is the first known case of DENV-4 encephalitis with complete recovery. Published version 2018-08-29T06:12:23Z 2019-12-06T17:02:15Z 2018-08-29T06:12:23Z 2019-12-06T17:02:15Z 2017 Journal Article Ng, D. H. L., & Sadarangani, S. P. (2017). “Locked in a cage”—A case of dengue virus 4 encephalitis. PLOS Neglected Tropical Diseases, 11(5), e0005369-. doi: 10.1371/journal.pntd.0005369 1935-2727 https://hdl.handle.net/10356/88391 http://hdl.handle.net/10220/45723 10.1371/journal.pntd.0005369 en PLOS Neglected Tropical Diseases © 2017 Ng, Sadarangani. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. 6 p. application/pdf |
| spellingShingle | Virus Encephalitis Dengue DRNTU::Science::Medicine Ng, Deborah H. L. Sadarangani, Sapna P. “Locked in a cage”—A case of dengue virus 4 encephalitis |
| title | “Locked in a cage”—A case of dengue virus 4 encephalitis |
| title_full | “Locked in a cage”—A case of dengue virus 4 encephalitis |
| title_fullStr | “Locked in a cage”—A case of dengue virus 4 encephalitis |
| title_full_unstemmed | “Locked in a cage”—A case of dengue virus 4 encephalitis |
| title_short | “Locked in a cage”—A case of dengue virus 4 encephalitis |
| title_sort | locked in a cage a case of dengue virus 4 encephalitis |
| topic | Virus Encephalitis Dengue DRNTU::Science::Medicine |
| url | https://hdl.handle.net/10356/88391 http://hdl.handle.net/10220/45723 |
| work_keys_str_mv | AT ngdeborahhl lockedinacageacaseofdenguevirus4encephalitis AT sadaranganisapnap lockedinacageacaseofdenguevirus4encephalitis |