Controlled nanoparticle release from stable magnetic microbubble oscillations
Magnetic microbubbles (MMBs) are microbubbles (MBs) coated with magnetic nanoparticles (NPs). MMBs not only maintain the acoustic properties of MBs, but also serve as an important contrast agent for magnetic resonance imaging. Such dual-modality functionality makes MMBs particularly useful for a wid...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Journal Article |
| Language: | English |
| Published: |
2018
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| Online Access: | https://hdl.handle.net/10356/88509 http://hdl.handle.net/10220/46924 |
| _version_ | 1811685286113968128 |
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| author | Gao, Yu Chan, Chon U. Gu, Qiushi Lin, Xudong Zhang, Wencong Yeo, David Chen Loong Alsema, Astrid Marlies Arora, Manish Chong, Mark Seow Khoon Shi, Peng Ohl, Claus-Dieter Xu, Chenjie |
| author2 | School of Chemical and Biomedical Engineering |
| author_facet | School of Chemical and Biomedical Engineering Gao, Yu Chan, Chon U. Gu, Qiushi Lin, Xudong Zhang, Wencong Yeo, David Chen Loong Alsema, Astrid Marlies Arora, Manish Chong, Mark Seow Khoon Shi, Peng Ohl, Claus-Dieter Xu, Chenjie |
| author_sort | Gao, Yu |
| collection | NTU |
| description | Magnetic microbubbles (MMBs) are microbubbles (MBs) coated with magnetic nanoparticles (NPs). MMBs not only maintain the acoustic properties of MBs, but also serve as an important contrast agent for magnetic resonance imaging. Such dual-modality functionality makes MMBs particularly useful for a wide range of biomedical applications, such as localized drug/gene delivery. This article reports the ability of MMBs to release their particle cargo on demand under stable oscillation. When stimulated by ultrasound at resonant frequencies, MMBs of 450 nm to 200 μm oscillate in volume and surface modes. Above an oscillation threshold, NPs are released from the MMB shell and can travel hundreds of micrometers from the surface of the bubble. The migration of NPs from MMBs can be described with a force balance model. With this technology, we deliver doxorubicin-containing poly(lactic-co-glycolic acid) particles across a physiological barrier both in vitro and in vivo, with a 18-fold and 5-fold increase in NP delivery to the heart tissue of zebrafish and tumor tissue of mouse, respectively. The penetration of released NPs in tissues is also improved. The ability to remotely control the release of NPs from MMBs suggests opportunities for targeted drug delivery through/into tissues that are not easily diffused through or penetrated. |
| first_indexed | 2024-10-01T04:42:06Z |
| format | Journal Article |
| id | ntu-10356/88509 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T04:42:06Z |
| publishDate | 2018 |
| record_format | dspace |
| spelling | ntu-10356/885092023-12-29T06:48:09Z Controlled nanoparticle release from stable magnetic microbubble oscillations Gao, Yu Chan, Chon U. Gu, Qiushi Lin, Xudong Zhang, Wencong Yeo, David Chen Loong Alsema, Astrid Marlies Arora, Manish Chong, Mark Seow Khoon Shi, Peng Ohl, Claus-Dieter Xu, Chenjie School of Chemical and Biomedical Engineering School of Physical and Mathematical Sciences NTU-Northwestern Institute for Nanomedicine Histology DRNTU::Engineering::Chemical engineering Acoustic Properties Magnetic microbubbles (MMBs) are microbubbles (MBs) coated with magnetic nanoparticles (NPs). MMBs not only maintain the acoustic properties of MBs, but also serve as an important contrast agent for magnetic resonance imaging. Such dual-modality functionality makes MMBs particularly useful for a wide range of biomedical applications, such as localized drug/gene delivery. This article reports the ability of MMBs to release their particle cargo on demand under stable oscillation. When stimulated by ultrasound at resonant frequencies, MMBs of 450 nm to 200 μm oscillate in volume and surface modes. Above an oscillation threshold, NPs are released from the MMB shell and can travel hundreds of micrometers from the surface of the bubble. The migration of NPs from MMBs can be described with a force balance model. With this technology, we deliver doxorubicin-containing poly(lactic-co-glycolic acid) particles across a physiological barrier both in vitro and in vivo, with a 18-fold and 5-fold increase in NP delivery to the heart tissue of zebrafish and tumor tissue of mouse, respectively. The penetration of released NPs in tissues is also improved. The ability to remotely control the release of NPs from MMBs suggests opportunities for targeted drug delivery through/into tissues that are not easily diffused through or penetrated. Published version 2018-12-12T07:18:48Z 2019-12-06T17:04:50Z 2018-12-12T07:18:48Z 2019-12-06T17:04:50Z 2016 Journal Article Gao, Y., Chan, C. U., Gu, Q., Lin, X., Zhang, W., Yeo, D. C. L., Alsema, A. M., et al. (2016). Controlled nanoparticle release from stable magnetic microbubble oscillations. NPG Asia Materials, 8(4), e260-. doi:10.1038/am.2016.37 https://hdl.handle.net/10356/88509 http://hdl.handle.net/10220/46924 10.1038/am.2016.37 en NPG Asia Materials © 2016 The Author(s) (Nature Publishing Group). This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ 10 p. application/pdf |
| spellingShingle | Histology DRNTU::Engineering::Chemical engineering Acoustic Properties Gao, Yu Chan, Chon U. Gu, Qiushi Lin, Xudong Zhang, Wencong Yeo, David Chen Loong Alsema, Astrid Marlies Arora, Manish Chong, Mark Seow Khoon Shi, Peng Ohl, Claus-Dieter Xu, Chenjie Controlled nanoparticle release from stable magnetic microbubble oscillations |
| title | Controlled nanoparticle release from stable magnetic microbubble oscillations |
| title_full | Controlled nanoparticle release from stable magnetic microbubble oscillations |
| title_fullStr | Controlled nanoparticle release from stable magnetic microbubble oscillations |
| title_full_unstemmed | Controlled nanoparticle release from stable magnetic microbubble oscillations |
| title_short | Controlled nanoparticle release from stable magnetic microbubble oscillations |
| title_sort | controlled nanoparticle release from stable magnetic microbubble oscillations |
| topic | Histology DRNTU::Engineering::Chemical engineering Acoustic Properties |
| url | https://hdl.handle.net/10356/88509 http://hdl.handle.net/10220/46924 |
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