Data for iTRAQ profiling of micro-vesicular plasma specimens : in search of potential prognostic circulatory biomarkers for Lacunar infarction
To discover potential prognostic biomarkers of Lacunar infarction (LACI), here we present quantitative proteomics data of plasma microvesicle-enriched fraction derived by comparative isobaric profiling of three groups of prospectively followed-up LACI patients (LACI – no adverse outcome, LACI –recur...
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| Format: | Journal Article |
| Language: | English |
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2018
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| Online Access: | https://hdl.handle.net/10356/88675 http://hdl.handle.net/10220/45916 |
| _version_ | 1824455418539147264 |
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| author | Datta, Arnab Sze, Siu Kwan |
| author2 | School of Biological Sciences |
| author_facet | School of Biological Sciences Datta, Arnab Sze, Siu Kwan |
| author_sort | Datta, Arnab |
| collection | NTU |
| description | To discover potential prognostic biomarkers of Lacunar infarction (LACI), here we present quantitative proteomics data of plasma microvesicle-enriched fraction derived by comparative isobaric profiling of three groups of prospectively followed-up LACI patients (LACI – no adverse outcome, LACI –recurrent vascular event and LACI – cognitive decline) and a demographically matched control group. We confidently (unused prot score >3, FDR=1.1%) identified 183 proteins, 43 out of which were significantly regulated (p-value<0.05) in at least one of the three LACI groups in comparison to control group. Bioinformatics analysis and data mining revealed upregulation of brain-specific proteins including myelin basic protein, proteins of coagulation cascade (e.g., fibrinogen alpha chain, fibrinogen beta chain) and focal adhesion (e.g., integrin alpha-IIb, talin-1, and filamin-A) while albumin was downregulated in both groups of patients with adverse outcome. The data of this study are also in line with our previously published article entitled “Discovery of prognostic biomarker candidates of Lacunar infarction by quantitative proteomics of microvesicles enriched plasma” by Datta et al. (2014). The raw data had been deposited to the ProteomeXchange consortium with identifier PXD000748. |
| first_indexed | 2025-02-19T03:37:54Z |
| format | Journal Article |
| id | ntu-10356/88675 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2025-02-19T03:37:54Z |
| publishDate | 2018 |
| record_format | dspace |
| spelling | ntu-10356/886752023-02-28T17:02:44Z Data for iTRAQ profiling of micro-vesicular plasma specimens : in search of potential prognostic circulatory biomarkers for Lacunar infarction Datta, Arnab Sze, Siu Kwan School of Biological Sciences Lacunar Infarction Quantitative Proteomics DRNTU::Science::Biological sciences To discover potential prognostic biomarkers of Lacunar infarction (LACI), here we present quantitative proteomics data of plasma microvesicle-enriched fraction derived by comparative isobaric profiling of three groups of prospectively followed-up LACI patients (LACI – no adverse outcome, LACI –recurrent vascular event and LACI – cognitive decline) and a demographically matched control group. We confidently (unused prot score >3, FDR=1.1%) identified 183 proteins, 43 out of which were significantly regulated (p-value<0.05) in at least one of the three LACI groups in comparison to control group. Bioinformatics analysis and data mining revealed upregulation of brain-specific proteins including myelin basic protein, proteins of coagulation cascade (e.g., fibrinogen alpha chain, fibrinogen beta chain) and focal adhesion (e.g., integrin alpha-IIb, talin-1, and filamin-A) while albumin was downregulated in both groups of patients with adverse outcome. The data of this study are also in line with our previously published article entitled “Discovery of prognostic biomarker candidates of Lacunar infarction by quantitative proteomics of microvesicles enriched plasma” by Datta et al. (2014). The raw data had been deposited to the ProteomeXchange consortium with identifier PXD000748. NRF (Natl Research Foundation, S’pore) NMRC (Natl Medical Research Council, S’pore) MOH (Min. of Health, S’pore) Published version 2018-09-10T07:38:03Z 2019-12-06T17:08:34Z 2018-09-10T07:38:03Z 2019-12-06T17:08:34Z 2015 Journal Article Datta, A., & Sze, S. K. (2015). Data for iTRAQ profiling of micro-vesicular plasma specimens : in search of potential prognostic circulatory biomarkers for Lacunar infarction. Data in Brief, 4, 510-517. doi:10.1016/j.dib.2015.07.021 https://hdl.handle.net/10356/88675 http://hdl.handle.net/10220/45916 10.1016/j.dib.2015.07.021 26966714 en Data in Brief © 2015 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). 8 p. application/pdf |
| spellingShingle | Lacunar Infarction Quantitative Proteomics DRNTU::Science::Biological sciences Datta, Arnab Sze, Siu Kwan Data for iTRAQ profiling of micro-vesicular plasma specimens : in search of potential prognostic circulatory biomarkers for Lacunar infarction |
| title | Data for iTRAQ profiling of micro-vesicular plasma specimens : in search of potential prognostic circulatory biomarkers for Lacunar infarction |
| title_full | Data for iTRAQ profiling of micro-vesicular plasma specimens : in search of potential prognostic circulatory biomarkers for Lacunar infarction |
| title_fullStr | Data for iTRAQ profiling of micro-vesicular plasma specimens : in search of potential prognostic circulatory biomarkers for Lacunar infarction |
| title_full_unstemmed | Data for iTRAQ profiling of micro-vesicular plasma specimens : in search of potential prognostic circulatory biomarkers for Lacunar infarction |
| title_short | Data for iTRAQ profiling of micro-vesicular plasma specimens : in search of potential prognostic circulatory biomarkers for Lacunar infarction |
| title_sort | data for itraq profiling of micro vesicular plasma specimens in search of potential prognostic circulatory biomarkers for lacunar infarction |
| topic | Lacunar Infarction Quantitative Proteomics DRNTU::Science::Biological sciences |
| url | https://hdl.handle.net/10356/88675 http://hdl.handle.net/10220/45916 |
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