Macrotheranostic Probe with Disease-activated Near-infrared Fluorescence, Photoacoustic and Photothermal Signals for Imaging-guided Therapy
Theranostics provides opportunities for precision cancer therapy. However, theranostic systems that simultaneously turn on their diagnostic signal and pharmacological action only in respond to targeted biomarker have been less exploited. We herein report the synthesis of a smart macrotheranostic pro...
| Main Authors: | , , , , , |
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| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
| Published: |
2018
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| Online Access: | https://hdl.handle.net/10356/88773 http://hdl.handle.net/10220/44726 |
| _version_ | 1811684714863394816 |
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| author | Zhen, Xu Zhang, Jianjian Huang, Jiaguo Xie, Chen Miao, Qingqing Pu, Kanyi |
| author2 | School of Chemical and Biomedical Engineering |
| author_facet | School of Chemical and Biomedical Engineering Zhen, Xu Zhang, Jianjian Huang, Jiaguo Xie, Chen Miao, Qingqing Pu, Kanyi |
| author_sort | Zhen, Xu |
| collection | NTU |
| description | Theranostics provides opportunities for precision cancer therapy. However, theranostic systems that simultaneously turn on their diagnostic signal and pharmacological action only in respond to targeted biomarker have been less exploited. We herein report the synthesis of a smart macrotheranostic probe that specifically turns on near‐infrared fluorescence, photoacoustic and photothermal signals in the presence of cancer‐overexpressed enzyme for imaging‐guided cancer therapy. Supervisor to the small‐molecule counterpart probe, the macrotheranostic probe has an ideal biodistribution and renal clearance, permitting passive targeting of tumor, in‐situ enzymatic activation of multimodal signals, and effective photothermal therapy. Our study thus provides a macromolecular approach towards activatable multimodal phototheranostics. |
| first_indexed | 2024-10-01T04:33:01Z |
| format | Journal Article |
| id | ntu-10356/88773 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T04:33:01Z |
| publishDate | 2018 |
| record_format | dspace |
| spelling | ntu-10356/887732023-12-29T06:47:54Z Macrotheranostic Probe with Disease-activated Near-infrared Fluorescence, Photoacoustic and Photothermal Signals for Imaging-guided Therapy Zhen, Xu Zhang, Jianjian Huang, Jiaguo Xie, Chen Miao, Qingqing Pu, Kanyi School of Chemical and Biomedical Engineering Activatable Macrotheranostic Probe β-Galactosidase Theranostics provides opportunities for precision cancer therapy. However, theranostic systems that simultaneously turn on their diagnostic signal and pharmacological action only in respond to targeted biomarker have been less exploited. We herein report the synthesis of a smart macrotheranostic probe that specifically turns on near‐infrared fluorescence, photoacoustic and photothermal signals in the presence of cancer‐overexpressed enzyme for imaging‐guided cancer therapy. Supervisor to the small‐molecule counterpart probe, the macrotheranostic probe has an ideal biodistribution and renal clearance, permitting passive targeting of tumor, in‐situ enzymatic activation of multimodal signals, and effective photothermal therapy. Our study thus provides a macromolecular approach towards activatable multimodal phototheranostics. MOE (Min. of Education, S’pore) Accepted version 2018-04-26T05:32:23Z 2019-12-06T17:10:38Z 2018-04-26T05:32:23Z 2019-12-06T17:10:38Z 2018 2018 Journal Article Zhen, X., Zhang, J., Huang, J., Xie, C., Miao, Q., & Pu, K. (2018). Macrotheranostic Probe with Disease-activated Near-infrared Fluorescence, Photoacoustic and Photothermal Signals for Imaging-guided Therapy. Angewandte Chemie International Edition, in press. 1433-7851 https://hdl.handle.net/10356/88773 http://hdl.handle.net/10220/44726 10.1002/anie.201803321 206475 en Angewandte Chemie International Edition © 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim. This is the author created version of a work that has been peer reviewed and accepted for publication by Angewandte Chemie International Edition, Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim. It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document. The published version is available at: [https://doi.org/10.1002/anie.201803321]. 5 p. application/pdf |
| spellingShingle | Activatable Macrotheranostic Probe β-Galactosidase Zhen, Xu Zhang, Jianjian Huang, Jiaguo Xie, Chen Miao, Qingqing Pu, Kanyi Macrotheranostic Probe with Disease-activated Near-infrared Fluorescence, Photoacoustic and Photothermal Signals for Imaging-guided Therapy |
| title | Macrotheranostic Probe with Disease-activated Near-infrared Fluorescence, Photoacoustic and Photothermal Signals for Imaging-guided Therapy |
| title_full | Macrotheranostic Probe with Disease-activated Near-infrared Fluorescence, Photoacoustic and Photothermal Signals for Imaging-guided Therapy |
| title_fullStr | Macrotheranostic Probe with Disease-activated Near-infrared Fluorescence, Photoacoustic and Photothermal Signals for Imaging-guided Therapy |
| title_full_unstemmed | Macrotheranostic Probe with Disease-activated Near-infrared Fluorescence, Photoacoustic and Photothermal Signals for Imaging-guided Therapy |
| title_short | Macrotheranostic Probe with Disease-activated Near-infrared Fluorescence, Photoacoustic and Photothermal Signals for Imaging-guided Therapy |
| title_sort | macrotheranostic probe with disease activated near infrared fluorescence photoacoustic and photothermal signals for imaging guided therapy |
| topic | Activatable Macrotheranostic Probe β-Galactosidase |
| url | https://hdl.handle.net/10356/88773 http://hdl.handle.net/10220/44726 |
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