Semiconducting Polymer Nanoenzymes with Photothermic Activity for Enhanced Cancer Therapy
Regulation of enzyme activity is fundamentally challenging but practically meaningful for biology and medicine. However, noninvasive remote control of enzyme activity in living systems has been rarely demonstrated and exploited for therapy. Herein, we synthesize a semiconducting polymer nanoenzyme w...
| Main Authors: | , , , , , |
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| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
| Published: |
2018
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10356/88819 http://hdl.handle.net/10220/44769 |
| _version_ | 1811683651845357568 |
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| author | Li, Jingchao Xie, Chen Huang, Jiaguo Jiang, Yuyan Miao, Qingqing Pu, Kanyi |
| author2 | School of Chemical and Biomedical Engineering |
| author_facet | School of Chemical and Biomedical Engineering Li, Jingchao Xie, Chen Huang, Jiaguo Jiang, Yuyan Miao, Qingqing Pu, Kanyi |
| author_sort | Li, Jingchao |
| collection | NTU |
| description | Regulation of enzyme activity is fundamentally challenging but practically meaningful for biology and medicine. However, noninvasive remote control of enzyme activity in living systems has been rarely demonstrated and exploited for therapy. Herein, we synthesize a semiconducting polymer nanoenzyme with photothermic activity for enhanced cancer therapy. Upon near‐infrared (NIR) light irradiation, the activity of the nanoenzyme can be enhanced by 3.5‐fold to efficiently digest collagen in the tumor extracellular matrix (ECM), leading to enhanced nanoparticle accumulation in tumors and consequently improved photothermal therapy (PTT). This study thus provides a promising strategy to remotely regulate enzyme activity for cancer therapy. |
| first_indexed | 2024-10-01T04:16:08Z |
| format | Journal Article |
| id | ntu-10356/88819 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T04:16:08Z |
| publishDate | 2018 |
| record_format | dspace |
| spelling | ntu-10356/888192023-12-29T06:47:34Z Semiconducting Polymer Nanoenzymes with Photothermic Activity for Enhanced Cancer Therapy Li, Jingchao Xie, Chen Huang, Jiaguo Jiang, Yuyan Miao, Qingqing Pu, Kanyi School of Chemical and Biomedical Engineering Polymer Nanoparticles Photothermal Therapy Regulation of enzyme activity is fundamentally challenging but practically meaningful for biology and medicine. However, noninvasive remote control of enzyme activity in living systems has been rarely demonstrated and exploited for therapy. Herein, we synthesize a semiconducting polymer nanoenzyme with photothermic activity for enhanced cancer therapy. Upon near‐infrared (NIR) light irradiation, the activity of the nanoenzyme can be enhanced by 3.5‐fold to efficiently digest collagen in the tumor extracellular matrix (ECM), leading to enhanced nanoparticle accumulation in tumors and consequently improved photothermal therapy (PTT). This study thus provides a promising strategy to remotely regulate enzyme activity for cancer therapy. MOE (Min. of Education, S’pore) Accepted version 2018-05-09T09:28:53Z 2019-12-06T17:11:31Z 2018-05-09T09:28:53Z 2019-12-06T17:11:31Z 2018 2018 Journal Article Li, J., Xie, C., Huang, J., Jiang, Y., Miao, Q., & Pu, K. (2018). Semiconducting Polymer Nanoenzymes with Photothermic Activity for Enhanced Cancer Therapy. Angewandte Chemie International Edition, 57(15), 3995-3998. 1433-7851 https://hdl.handle.net/10356/88819 http://hdl.handle.net/10220/44769 10.1002/anie.201800511 206481 en Angewandte Chemie International Edition © 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. This is the author created version of a work that has been peer reviewed and accepted for publication by Angewandte Chemie International Edition, WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document. The published version is available at: [https://dx.doi.org/10.1002/anie.201800511]. application/pdf |
| spellingShingle | Polymer Nanoparticles Photothermal Therapy Li, Jingchao Xie, Chen Huang, Jiaguo Jiang, Yuyan Miao, Qingqing Pu, Kanyi Semiconducting Polymer Nanoenzymes with Photothermic Activity for Enhanced Cancer Therapy |
| title | Semiconducting Polymer Nanoenzymes with Photothermic Activity for Enhanced Cancer Therapy |
| title_full | Semiconducting Polymer Nanoenzymes with Photothermic Activity for Enhanced Cancer Therapy |
| title_fullStr | Semiconducting Polymer Nanoenzymes with Photothermic Activity for Enhanced Cancer Therapy |
| title_full_unstemmed | Semiconducting Polymer Nanoenzymes with Photothermic Activity for Enhanced Cancer Therapy |
| title_short | Semiconducting Polymer Nanoenzymes with Photothermic Activity for Enhanced Cancer Therapy |
| title_sort | semiconducting polymer nanoenzymes with photothermic activity for enhanced cancer therapy |
| topic | Polymer Nanoparticles Photothermal Therapy |
| url | https://hdl.handle.net/10356/88819 http://hdl.handle.net/10220/44769 |
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