Lipoprotein subclass profile after progressive energy deficits induced by calorie restriction or exercise
Weight loss, induced by chronic energy deficit, improves the blood lipid profile. However, the effects of an acute negative energy balance and the comparative efficacy of diet and exercise are not well-established. We determined the effects of progressive, acute energy deficits (20% or 40% of daily...
| Main Authors: | , , , , , , , |
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| Format: | Journal Article |
| Language: | English |
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2018
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| Online Access: | https://hdl.handle.net/10356/88924 http://hdl.handle.net/10220/46993 |
| _version_ | 1811682920160559104 |
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| author | Ding, Cherlyn Chan, Zhiling Lo, Jezebel Choo, John Magkos, Faidon Chooi, Yu Chung Ding, Benjamin T. K. Leow, Melvin Khee-Shing |
| author2 | Lee Kong Chian School of Medicine (LKCMedicine) |
| author_facet | Lee Kong Chian School of Medicine (LKCMedicine) Ding, Cherlyn Chan, Zhiling Lo, Jezebel Choo, John Magkos, Faidon Chooi, Yu Chung Ding, Benjamin T. K. Leow, Melvin Khee-Shing |
| author_sort | Ding, Cherlyn |
| collection | NTU |
| description | Weight loss, induced by chronic energy deficit, improves the blood lipid profile. However, the effects of an acute negative energy balance and the comparative efficacy of diet and exercise are not well-established. We determined the effects of progressive, acute energy deficits (20% or 40% of daily energy requirements) induced by a single day of calorie restriction (n = 19) or aerobic exercise (n = 13) in healthy subjects (age: 26 ± 9 years; body mass index (BMI): 21.8 ± 2.9 kg/m2). Fasting plasma concentrations of very low-, intermediate-, low-, and high-density lipoprotein (VLDL, LDL, IDL, and HDL, respectively) particles and their subclasses were determined using nuclear magnetic resonance. Total plasma triglyceride and VLDL-triglyceride concentrations decreased after calorie restriction and exercise (all p ≤ 0.025); the pattern of change was linear with an increasing energy deficit (all p < 0.03), with no evidence of plateauing. The number of circulating large and medium VLDL particles decreased after diet and exercise (all p < 0.015), with no change in small VLDL particles. The concentrations of IDL, LDL, and HDL particles, their relative distributions, and the particle sizes were not altered. Our data indicate that an acute negative energy balance induced by calorie restriction and aerobic exercise reduces triglyceride concentrations in a dose-dependent manner, by decreasing circulating large and medium VLDL particles. |
| first_indexed | 2024-10-01T04:04:30Z |
| format | Journal Article |
| id | ntu-10356/88924 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T04:04:30Z |
| publishDate | 2018 |
| record_format | dspace |
| spelling | ntu-10356/889242020-11-01T05:16:18Z Lipoprotein subclass profile after progressive energy deficits induced by calorie restriction or exercise Ding, Cherlyn Chan, Zhiling Lo, Jezebel Choo, John Magkos, Faidon Chooi, Yu Chung Ding, Benjamin T. K. Leow, Melvin Khee-Shing Lee Kong Chian School of Medicine (LKCMedicine) Lipoproteins Triglyceride DRNTU::Science::Medicine Weight loss, induced by chronic energy deficit, improves the blood lipid profile. However, the effects of an acute negative energy balance and the comparative efficacy of diet and exercise are not well-established. We determined the effects of progressive, acute energy deficits (20% or 40% of daily energy requirements) induced by a single day of calorie restriction (n = 19) or aerobic exercise (n = 13) in healthy subjects (age: 26 ± 9 years; body mass index (BMI): 21.8 ± 2.9 kg/m2). Fasting plasma concentrations of very low-, intermediate-, low-, and high-density lipoprotein (VLDL, LDL, IDL, and HDL, respectively) particles and their subclasses were determined using nuclear magnetic resonance. Total plasma triglyceride and VLDL-triglyceride concentrations decreased after calorie restriction and exercise (all p ≤ 0.025); the pattern of change was linear with an increasing energy deficit (all p < 0.03), with no evidence of plateauing. The number of circulating large and medium VLDL particles decreased after diet and exercise (all p < 0.015), with no change in small VLDL particles. The concentrations of IDL, LDL, and HDL particles, their relative distributions, and the particle sizes were not altered. Our data indicate that an acute negative energy balance induced by calorie restriction and aerobic exercise reduces triglyceride concentrations in a dose-dependent manner, by decreasing circulating large and medium VLDL particles. ASTAR (Agency for Sci., Tech. and Research, S’pore) Published version 2018-12-17T05:33:09Z 2019-12-06T17:13:50Z 2018-12-17T05:33:09Z 2019-12-06T17:13:50Z 2018 Journal Article Chooi, Y. C., Ding, C., Chan, Z., Lo, J., Choo, J., Ding, B. T. K., . . . Magkos, F. (2018). Lipoprotein subclass profile after progressive energy deficits induced by calorie restriction or exercise. Nutrients, 10(11), 1814-. doi: 10.3390/nu10111814 2072-6643 https://hdl.handle.net/10356/88924 http://hdl.handle.net/10220/46993 10.3390/nu10111814 en Nutrients © 2018 The Author(s). Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). 14 p. application/pdf |
| spellingShingle | Lipoproteins Triglyceride DRNTU::Science::Medicine Ding, Cherlyn Chan, Zhiling Lo, Jezebel Choo, John Magkos, Faidon Chooi, Yu Chung Ding, Benjamin T. K. Leow, Melvin Khee-Shing Lipoprotein subclass profile after progressive energy deficits induced by calorie restriction or exercise |
| title | Lipoprotein subclass profile after progressive energy deficits induced by calorie restriction or exercise |
| title_full | Lipoprotein subclass profile after progressive energy deficits induced by calorie restriction or exercise |
| title_fullStr | Lipoprotein subclass profile after progressive energy deficits induced by calorie restriction or exercise |
| title_full_unstemmed | Lipoprotein subclass profile after progressive energy deficits induced by calorie restriction or exercise |
| title_short | Lipoprotein subclass profile after progressive energy deficits induced by calorie restriction or exercise |
| title_sort | lipoprotein subclass profile after progressive energy deficits induced by calorie restriction or exercise |
| topic | Lipoproteins Triglyceride DRNTU::Science::Medicine |
| url | https://hdl.handle.net/10356/88924 http://hdl.handle.net/10220/46993 |
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