Multiple aperture synthetic optical coherence tomography for biological tissue imaging
An inherent compromise must be made between transverse resolution and depth of focus (DOF) in spectral domain optical coherence tomography (SD-OCT). Thus far, OCT has not been capable of providing a sufficient DOF to stably acquire cellular-resolution images. We previously reported a novel technique...
| Main Authors: | , , , , , , , , , , |
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| Format: | Journal Article |
| Language: | English |
| Published: |
2018
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| Online Access: | https://hdl.handle.net/10356/89188 http://hdl.handle.net/10220/44808 |
| _version_ | 1826117065159737344 |
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| author | Bo, En Ge, Xin Wang, Lulu Wu, Xuan Luo, Yuemei Chen, Shufen Chen, Si Liang, Haitao Ni, Guangming Yu, Xiaojun Liu, Linbo |
| author2 | School of Chemical and Biomedical Engineering |
| author_facet | School of Chemical and Biomedical Engineering Bo, En Ge, Xin Wang, Lulu Wu, Xuan Luo, Yuemei Chen, Shufen Chen, Si Liang, Haitao Ni, Guangming Yu, Xiaojun Liu, Linbo |
| author_sort | Bo, En |
| collection | NTU |
| description | An inherent compromise must be made between transverse resolution and depth of focus (DOF) in spectral domain optical coherence tomography (SD-OCT). Thus far, OCT has not been capable of providing a sufficient DOF to stably acquire cellular-resolution images. We previously reported a novel technique named multiple aperture synthesis (MAS) to extend the DOF in high-resolution OCT [Optica 4, 701 (2017)]. In this technique, the illumination beam is scanned across the objective lens pupil plane by being steered at the pinhole using a custom-made microcylindrical lens. Images captured via multiple distinctive apertures were digitally refocused, which is similar to synthetic aperture radar. In this study, we applied this technique for the first time to image both a homemade microparticle sample and biological tissue. The results demonstrated the feasibility and efficacy of high-resolution biological tissue imaging with a dramatic DOF extension. |
| first_indexed | 2024-10-01T04:21:39Z |
| format | Journal Article |
| id | ntu-10356/89188 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T04:21:39Z |
| publishDate | 2018 |
| record_format | dspace |
| spelling | ntu-10356/891882020-03-07T14:02:36Z Multiple aperture synthetic optical coherence tomography for biological tissue imaging Bo, En Ge, Xin Wang, Lulu Wu, Xuan Luo, Yuemei Chen, Shufen Chen, Si Liang, Haitao Ni, Guangming Yu, Xiaojun Liu, Linbo School of Chemical and Biomedical Engineering School of Electrical and Electronic Engineering Medical And Biological Imaging Optical Coherence Tomography An inherent compromise must be made between transverse resolution and depth of focus (DOF) in spectral domain optical coherence tomography (SD-OCT). Thus far, OCT has not been capable of providing a sufficient DOF to stably acquire cellular-resolution images. We previously reported a novel technique named multiple aperture synthesis (MAS) to extend the DOF in high-resolution OCT [Optica 4, 701 (2017)]. In this technique, the illumination beam is scanned across the objective lens pupil plane by being steered at the pinhole using a custom-made microcylindrical lens. Images captured via multiple distinctive apertures were digitally refocused, which is similar to synthetic aperture radar. In this study, we applied this technique for the first time to image both a homemade microparticle sample and biological tissue. The results demonstrated the feasibility and efficacy of high-resolution biological tissue imaging with a dramatic DOF extension. NRF (Natl Research Foundation, S’pore) MOE (Min. of Education, S’pore) NMRC (Natl Medical Research Council, S’pore) Published version 2018-05-16T07:42:48Z 2019-12-06T17:19:48Z 2018-05-16T07:42:48Z 2019-12-06T17:19:48Z 2018 Journal Article Bo, E., Ge, X., Wang, L., Wu, X., Luo, Y., Chen, S., et al. (2018). Multiple aperture synthetic optical coherence tomography for biological tissue imaging. Optics Express, 26(2), 772-780. https://hdl.handle.net/10356/89188 http://hdl.handle.net/10220/44808 10.1364/OE.26.000772 en Optics Express © 2018 Optical Society of America. This paper was published in Optics Express and is made available as an electronic reprint (preprint) with permission of Optical Society of America. The published version is available at: [http://dx.doi.org/10.1364/OE.26.000772]. One print or electronic copy may be made for personal use only. Systematic or multiple reproduction, distribution to multiple locations via electronic or other means, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper is prohibited and is subject to penalties under law. 9 p. application/pdf |
| spellingShingle | Medical And Biological Imaging Optical Coherence Tomography Bo, En Ge, Xin Wang, Lulu Wu, Xuan Luo, Yuemei Chen, Shufen Chen, Si Liang, Haitao Ni, Guangming Yu, Xiaojun Liu, Linbo Multiple aperture synthetic optical coherence tomography for biological tissue imaging |
| title | Multiple aperture synthetic optical coherence tomography for biological tissue imaging |
| title_full | Multiple aperture synthetic optical coherence tomography for biological tissue imaging |
| title_fullStr | Multiple aperture synthetic optical coherence tomography for biological tissue imaging |
| title_full_unstemmed | Multiple aperture synthetic optical coherence tomography for biological tissue imaging |
| title_short | Multiple aperture synthetic optical coherence tomography for biological tissue imaging |
| title_sort | multiple aperture synthetic optical coherence tomography for biological tissue imaging |
| topic | Medical And Biological Imaging Optical Coherence Tomography |
| url | https://hdl.handle.net/10356/89188 http://hdl.handle.net/10220/44808 |
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