Structural design of microbicidal cationic oligomers and their synergistic interaction with azoles against Candida albicans
Membrane-disrupting synthetic antimicrobial polymers have been well developed as antimicrobial peptide (AMP) mimics to mitigate antimicrobial resistance (AMR). However, synthetic polymers possess inherent drawbacks, being a mixture of different chain lengths, which restricts their clinical applicati...
| Main Authors: | , , , |
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| Format: | Journal Article |
| Language: | English |
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2019
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| Online Access: | https://hdl.handle.net/10356/89198 http://hdl.handle.net/10220/49898 |
| _version_ | 1826119421712662528 |
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| author | Yuan, Yuan Zhou, Feng Su, Haibin Zhang, Yugen |
| author2 | School of Materials Science & Engineering |
| author_facet | School of Materials Science & Engineering Yuan, Yuan Zhou, Feng Su, Haibin Zhang, Yugen |
| author_sort | Yuan, Yuan |
| collection | NTU |
| description | Membrane-disrupting synthetic antimicrobial polymers have been well developed as antimicrobial peptide (AMP) mimics to mitigate antimicrobial resistance (AMR). However, synthetic polymers possess inherent drawbacks, being a mixture of different chain lengths, which restricts their clinical applications. In fact, synthetic oligomers with defined chain length and molecular structure could be better representatives of AMPs. Herein, a series of novel imidazolium-ammonium oligomers developed in this work exhibit excellent broad spectrum antimicrobial activity, specifically the salient structure dependent high efficiency against C. albicans. Moreover, synergistic effect emerged when the combined azoles and synthetic oligomers were applied against C. albicans. The detail structural coupling between azoles and oligomers was scrutinized through molecular dynamics simulations to unravel the interaction details with the atomistic resolution. The labile interaction between oligomer and azoles facilitated the transfer of drug into fungal cells, which can be a synergistic solution to prevent the development of resistance on C. albicans. |
| first_indexed | 2024-10-01T04:59:42Z |
| format | Journal Article |
| id | ntu-10356/89198 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T04:59:42Z |
| publishDate | 2019 |
| record_format | dspace |
| spelling | ntu-10356/891982023-07-14T15:52:17Z Structural design of microbicidal cationic oligomers and their synergistic interaction with azoles against Candida albicans Yuan, Yuan Zhou, Feng Su, Haibin Zhang, Yugen School of Materials Science & Engineering Engineering::Materials Oligomers Antimicrobial Resistance Membrane-disrupting synthetic antimicrobial polymers have been well developed as antimicrobial peptide (AMP) mimics to mitigate antimicrobial resistance (AMR). However, synthetic polymers possess inherent drawbacks, being a mixture of different chain lengths, which restricts their clinical applications. In fact, synthetic oligomers with defined chain length and molecular structure could be better representatives of AMPs. Herein, a series of novel imidazolium-ammonium oligomers developed in this work exhibit excellent broad spectrum antimicrobial activity, specifically the salient structure dependent high efficiency against C. albicans. Moreover, synergistic effect emerged when the combined azoles and synthetic oligomers were applied against C. albicans. The detail structural coupling between azoles and oligomers was scrutinized through molecular dynamics simulations to unravel the interaction details with the atomistic resolution. The labile interaction between oligomer and azoles facilitated the transfer of drug into fungal cells, which can be a synergistic solution to prevent the development of resistance on C. albicans. ASTAR (Agency for Sci., Tech. and Research, S’pore) Published version 2019-09-09T03:02:20Z 2019-12-06T17:20:02Z 2019-09-09T03:02:20Z 2019-12-06T17:20:02Z 2019 Journal Article Yuan, Y., Zhou, F., Su, H., & Zhang, Y. (2019). Structural design of microbicidal cationic oligomers and their synergistic interaction with azoles against Candida albicans. Scientific Reports, 9, 11885-. doi:10.1038/s41598-019-48322-x https://hdl.handle.net/10356/89198 http://hdl.handle.net/10220/49898 10.1038/s41598-019-48322-x en Scientific Reports © 2019 The Author(s). This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. 11 p. application/pdf |
| spellingShingle | Engineering::Materials Oligomers Antimicrobial Resistance Yuan, Yuan Zhou, Feng Su, Haibin Zhang, Yugen Structural design of microbicidal cationic oligomers and their synergistic interaction with azoles against Candida albicans |
| title | Structural design of microbicidal cationic oligomers and their synergistic interaction with azoles against Candida albicans |
| title_full | Structural design of microbicidal cationic oligomers and their synergistic interaction with azoles against Candida albicans |
| title_fullStr | Structural design of microbicidal cationic oligomers and their synergistic interaction with azoles against Candida albicans |
| title_full_unstemmed | Structural design of microbicidal cationic oligomers and their synergistic interaction with azoles against Candida albicans |
| title_short | Structural design of microbicidal cationic oligomers and their synergistic interaction with azoles against Candida albicans |
| title_sort | structural design of microbicidal cationic oligomers and their synergistic interaction with azoles against candida albicans |
| topic | Engineering::Materials Oligomers Antimicrobial Resistance |
| url | https://hdl.handle.net/10356/89198 http://hdl.handle.net/10220/49898 |
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