Metformin from mother to unborn child – are there unwarranted effects?
For more than 40 years, metformin has been used before and during pregnancy. However, it is important to note that metformin can cross the placenta and circulate in the developing foetus. Recent studies reported that the concentration of metformin in foetal cord blood ranges from half to nearly the...
| Main Authors: | , , |
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| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
| Published: |
2018
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| Online Access: | https://hdl.handle.net/10356/89278 http://hdl.handle.net/10220/46140 |
| _version_ | 1826113445604360192 |
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| author | Nguyen, Linh Chan, Shiao-Yng Teo, Adrian Kee Keong |
| author2 | School of Biological Sciences |
| author_facet | School of Biological Sciences Nguyen, Linh Chan, Shiao-Yng Teo, Adrian Kee Keong |
| author_sort | Nguyen, Linh |
| collection | NTU |
| description | For more than 40 years, metformin has been used before and during pregnancy. However, it is important to note that metformin can cross the placenta and circulate in the developing foetus. Recent studies reported that the concentration of metformin in foetal cord blood ranges from half to nearly the same concentration as in the maternal plasma. Since metformin has anti-cell growth and pro-apoptotic effects, there are persistent concerns over the use of metformin in early pregnancy. Current human studies are limited by sample size, lack of controls or, short follow-up durations. In this review, we examine the settings in which metformin can be passed on from mother to child during pregnancy and address the current controversies relating to the cellular and molecular mechanisms of metformin. Our efforts highlight the need for more data on the effects of metformin on general offspring health as well as further scrutiny into foetal development upon exposure to metformin. |
| first_indexed | 2024-10-01T03:23:21Z |
| format | Journal Article |
| id | ntu-10356/89278 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T03:23:21Z |
| publishDate | 2018 |
| record_format | dspace |
| spelling | ntu-10356/892782023-02-28T17:02:48Z Metformin from mother to unborn child – are there unwarranted effects? Nguyen, Linh Chan, Shiao-Yng Teo, Adrian Kee Keong School of Biological Sciences Lee Kong Chian School of Medicine (LKCMedicine) Metformin Pregnancy DRNTU::Science::Biological sciences For more than 40 years, metformin has been used before and during pregnancy. However, it is important to note that metformin can cross the placenta and circulate in the developing foetus. Recent studies reported that the concentration of metformin in foetal cord blood ranges from half to nearly the same concentration as in the maternal plasma. Since metformin has anti-cell growth and pro-apoptotic effects, there are persistent concerns over the use of metformin in early pregnancy. Current human studies are limited by sample size, lack of controls or, short follow-up durations. In this review, we examine the settings in which metformin can be passed on from mother to child during pregnancy and address the current controversies relating to the cellular and molecular mechanisms of metformin. Our efforts highlight the need for more data on the effects of metformin on general offspring health as well as further scrutiny into foetal development upon exposure to metformin. NRF (Natl Research Foundation, S’pore) ASTAR (Agency for Sci., Tech. and Research, S’pore) NMRC (Natl Medical Research Council, S’pore) MOH (Min. of Health, S’pore) Published version 2018-10-01T03:59:52Z 2019-12-06T17:21:49Z 2018-10-01T03:59:52Z 2019-12-06T17:21:49Z 2018 Journal Article Nguyen, L., Chan, S.-Y., & Teo, A. K. K. (2018). Metformin from mother to unborn child – are there unwarranted effects?. EBioMedicine, 35, 394-404. doi:10.1016/j.ebiom.2018.08.047 2352-3964 https://hdl.handle.net/10356/89278 http://hdl.handle.net/10220/46140 10.1016/j.ebiom.2018.08.047 en EBioMedicine © 2018 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). 11 p. application/pdf |
| spellingShingle | Metformin Pregnancy DRNTU::Science::Biological sciences Nguyen, Linh Chan, Shiao-Yng Teo, Adrian Kee Keong Metformin from mother to unborn child – are there unwarranted effects? |
| title | Metformin from mother to unborn child – are there unwarranted effects? |
| title_full | Metformin from mother to unborn child – are there unwarranted effects? |
| title_fullStr | Metformin from mother to unborn child – are there unwarranted effects? |
| title_full_unstemmed | Metformin from mother to unborn child – are there unwarranted effects? |
| title_short | Metformin from mother to unborn child – are there unwarranted effects? |
| title_sort | metformin from mother to unborn child are there unwarranted effects |
| topic | Metformin Pregnancy DRNTU::Science::Biological sciences |
| url | https://hdl.handle.net/10356/89278 http://hdl.handle.net/10220/46140 |
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