Working memory, age and education: A lifespan fMRI study
Ageing is associated with grey matter atrophy and changes in task-related neural activations. This study investigated the effects of age and education on neural activation during a spatial working memory task in 189 participants aged between 20–80 years old, whilst controlling for grey matter densit...
| Main Authors: | , , , |
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| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
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2018
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| Online Access: | https://hdl.handle.net/10356/89305 http://hdl.handle.net/10220/44870 |
| _version_ | 1826120054029156352 |
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| author | Archer, Jo A. Lee, Annie Qiu, Anqi Chen, Annabel Shen-Hsing |
| author2 | He, Huiguang |
| author_facet | He, Huiguang Archer, Jo A. Lee, Annie Qiu, Anqi Chen, Annabel Shen-Hsing |
| author_sort | Archer, Jo A. |
| collection | NTU |
| description | Ageing is associated with grey matter atrophy and changes in task-related neural activations. This study investigated the effects of age and education on neural activation during a spatial working memory task in 189 participants aged between 20–80 years old, whilst controlling for grey matter density. Age was related to linear decreases in neural activation in task activated areas, and this effect was no longer significant when adjusting for education or accuracy. Age was also related to cubic increases in neural activation in non-task related areas, such as the temporal gyrus, cuneus and cerebellum when adjusting for accuracy and education. These findings support previous lifespan datasets indicating linear age-related decreases in task activation, but non-linear increases in non-task related areas during episodic memory tasks. The findings also support past studies indicating education offers a form of cognitive reserve through providing a form of neural compensation and highlights the need to consider education in ageing studies. |
| first_indexed | 2024-10-01T05:09:55Z |
| format | Journal Article |
| id | ntu-10356/89305 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T05:09:55Z |
| publishDate | 2018 |
| record_format | dspace |
| spelling | ntu-10356/893052020-03-07T12:10:39Z Working memory, age and education: A lifespan fMRI study Archer, Jo A. Lee, Annie Qiu, Anqi Chen, Annabel Shen-Hsing He, Huiguang Lee Kong Chian School of Medicine (LKCMedicine) School of Humanities and Social Sciences Centre for Research and Development in Learning (CRADLE) Education Age Ageing is associated with grey matter atrophy and changes in task-related neural activations. This study investigated the effects of age and education on neural activation during a spatial working memory task in 189 participants aged between 20–80 years old, whilst controlling for grey matter density. Age was related to linear decreases in neural activation in task activated areas, and this effect was no longer significant when adjusting for education or accuracy. Age was also related to cubic increases in neural activation in non-task related areas, such as the temporal gyrus, cuneus and cerebellum when adjusting for accuracy and education. These findings support previous lifespan datasets indicating linear age-related decreases in task activation, but non-linear increases in non-task related areas during episodic memory tasks. The findings also support past studies indicating education offers a form of cognitive reserve through providing a form of neural compensation and highlights the need to consider education in ageing studies. MOE (Min. of Education, S’pore) NMRC (Natl Medical Research Council, S’pore) MOH (Min. of Health, S’pore) Published version 2018-05-23T04:38:24Z 2019-12-06T17:22:27Z 2018-05-23T04:38:24Z 2019-12-06T17:22:27Z 2018 Journal Article Archer, J. A., Lee, A., Qiu, A., & Chen, A. S.-H. (2018). Working memory, age and education: A lifespan fMRI study. PLOS ONE, 13(3), e0194878-. https://hdl.handle.net/10356/89305 http://hdl.handle.net/10220/44870 10.1371/journal.pone.0194878 en PLOS ONE © 2018 Archer et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. 19 p. application/pdf |
| spellingShingle | Education Age Archer, Jo A. Lee, Annie Qiu, Anqi Chen, Annabel Shen-Hsing Working memory, age and education: A lifespan fMRI study |
| title | Working memory, age and education: A lifespan fMRI study |
| title_full | Working memory, age and education: A lifespan fMRI study |
| title_fullStr | Working memory, age and education: A lifespan fMRI study |
| title_full_unstemmed | Working memory, age and education: A lifespan fMRI study |
| title_short | Working memory, age and education: A lifespan fMRI study |
| title_sort | working memory age and education a lifespan fmri study |
| topic | Education Age |
| url | https://hdl.handle.net/10356/89305 http://hdl.handle.net/10220/44870 |
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