Stimuli-responsive multifunctional glyconanoparticle platforms for targeted drug delivery and cancer cell imaging
Targeted bioimaging or chemotherapeutic drug delivery to achieve the desired therapeutic effects while minimizing side effects has attracted considerable research attention and remains a clinical challenge. Presented herein is a multi-component delivery system based on carbohydrate-functionalized go...
| Main Authors: | , , , , , , , |
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| Format: | Journal Article |
| Language: | English |
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2018
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| Online Access: | https://hdl.handle.net/10356/89314 http://hdl.handle.net/10220/44880 |
| _version_ | 1826125944791760896 |
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| author | Wu, Xumeng Tan, Yu Jia Toh, Hui Ting Nguyen, Lan Huong Kho, Shu Hui Chew, Sing Yian Yoon, Ho Sup Liu, Xue-Wei |
| author2 | Lee Kong Chian School of Medicine (LKCMedicine) |
| author_facet | Lee Kong Chian School of Medicine (LKCMedicine) Wu, Xumeng Tan, Yu Jia Toh, Hui Ting Nguyen, Lan Huong Kho, Shu Hui Chew, Sing Yian Yoon, Ho Sup Liu, Xue-Wei |
| author_sort | Wu, Xumeng |
| collection | NTU |
| description | Targeted bioimaging or chemotherapeutic drug delivery to achieve the desired therapeutic effects while minimizing side effects has attracted considerable research attention and remains a clinical challenge. Presented herein is a multi-component delivery system based on carbohydrate-functionalized gold nanoparticles conjugated with a fluorophore or prodrug. The system leverages active targeting based on carbohydrate–lectin interactions and release of the payload by biological thiols. Cell-type specific delivery of the activatable fluorophore was examined by confocal imaging on HepG2 cells, and displays distinct selectivity towards HepG2 cells over HeLa and NIH3T3 cells. The system was further developed into a drug delivery vehicle with camptothecin (CPT) as a model drug. It was demonstrated that the complex exhibits similar cytotoxicity to that of free CPT towards HepG2 cells, and is significantly less cytotoxic to normal HDF and NIH3T3 cells, indicating excellent specificity. The delivery vehicle itself exhibits excellent biocompatibility and offers an attractive strategy for cell-type specific delivery depending on the carbohydrates conjugated in the system. |
| first_indexed | 2024-10-01T06:44:40Z |
| format | Journal Article |
| id | ntu-10356/89314 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T06:44:40Z |
| publishDate | 2018 |
| record_format | dspace |
| spelling | ntu-10356/893142023-02-28T19:36:03Z Stimuli-responsive multifunctional glyconanoparticle platforms for targeted drug delivery and cancer cell imaging Wu, Xumeng Tan, Yu Jia Toh, Hui Ting Nguyen, Lan Huong Kho, Shu Hui Chew, Sing Yian Yoon, Ho Sup Liu, Xue-Wei Lee Kong Chian School of Medicine (LKCMedicine) School of Chemical and Biomedical Engineering School of Biological Sciences School of Physical and Mathematical Sciences Carbohydrates Biocompatibility Targeted bioimaging or chemotherapeutic drug delivery to achieve the desired therapeutic effects while minimizing side effects has attracted considerable research attention and remains a clinical challenge. Presented herein is a multi-component delivery system based on carbohydrate-functionalized gold nanoparticles conjugated with a fluorophore or prodrug. The system leverages active targeting based on carbohydrate–lectin interactions and release of the payload by biological thiols. Cell-type specific delivery of the activatable fluorophore was examined by confocal imaging on HepG2 cells, and displays distinct selectivity towards HepG2 cells over HeLa and NIH3T3 cells. The system was further developed into a drug delivery vehicle with camptothecin (CPT) as a model drug. It was demonstrated that the complex exhibits similar cytotoxicity to that of free CPT towards HepG2 cells, and is significantly less cytotoxic to normal HDF and NIH3T3 cells, indicating excellent specificity. The delivery vehicle itself exhibits excellent biocompatibility and offers an attractive strategy for cell-type specific delivery depending on the carbohydrates conjugated in the system. MOE (Min. of Education, S’pore) Published version 2018-05-23T06:35:18Z 2019-12-06T17:22:39Z 2018-05-23T06:35:18Z 2019-12-06T17:22:39Z 2017 Journal Article Wu, X., Tan, Y. J., Toh, H. T., Nguyen, L. H., Kho, S. H., et al. (2017). Stimuli-responsive multifunctional glyconanoparticle platforms for targeted drug delivery and cancer cell imaging. Chemical Science, 8(5), 3980-3988. 2041-6520 https://hdl.handle.net/10356/89314 http://hdl.handle.net/10220/44880 10.1039/C6SC05251G en Chemical Science © 2017 The Royal Society of Chemistry. Open Access Article. Published on 30 March 2017. Downloaded on 23/05/2018 07:08:11. This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. 9 p. application/pdf |
| spellingShingle | Carbohydrates Biocompatibility Wu, Xumeng Tan, Yu Jia Toh, Hui Ting Nguyen, Lan Huong Kho, Shu Hui Chew, Sing Yian Yoon, Ho Sup Liu, Xue-Wei Stimuli-responsive multifunctional glyconanoparticle platforms for targeted drug delivery and cancer cell imaging |
| title | Stimuli-responsive multifunctional glyconanoparticle platforms for targeted drug delivery and cancer cell imaging |
| title_full | Stimuli-responsive multifunctional glyconanoparticle platforms for targeted drug delivery and cancer cell imaging |
| title_fullStr | Stimuli-responsive multifunctional glyconanoparticle platforms for targeted drug delivery and cancer cell imaging |
| title_full_unstemmed | Stimuli-responsive multifunctional glyconanoparticle platforms for targeted drug delivery and cancer cell imaging |
| title_short | Stimuli-responsive multifunctional glyconanoparticle platforms for targeted drug delivery and cancer cell imaging |
| title_sort | stimuli responsive multifunctional glyconanoparticle platforms for targeted drug delivery and cancer cell imaging |
| topic | Carbohydrates Biocompatibility |
| url | https://hdl.handle.net/10356/89314 http://hdl.handle.net/10220/44880 |
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