pH-sensitive and biodegradable charge-transfer nanocomplex for second near-infrared photoacoustic tumor imaging
The emerging photoacoustic imaging (PAI), especially in the NIR window, offers reliable sensing for deep-penetration and high-resolution closing to clinical requirements. However, the contrast agents that are capable of specifically responding to the intricate biological environments, more important...
| Main Authors: | , , , , , , , , , , , , , |
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| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
| Published: |
2018
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| Online Access: | https://hdl.handle.net/10356/89425 http://hdl.handle.net/10220/47098 |
| _version_ | 1826113962765189120 |
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| author | Wang, Zhimin Upputuri, Paul Kumar Zhen, Xu Zhang, Ruochong Jiang, Yuyan Ai, Xiangzhao Zhang, Zhijun Hu, Ming Meng, Zhenyu Lu, Yunpeng Zheng, Yuanjing Pu, Kanyi Pramanik, Manojit Xing, Bengang |
| author2 | School of Electrical and Electronic Engineering |
| author_facet | School of Electrical and Electronic Engineering Wang, Zhimin Upputuri, Paul Kumar Zhen, Xu Zhang, Ruochong Jiang, Yuyan Ai, Xiangzhao Zhang, Zhijun Hu, Ming Meng, Zhenyu Lu, Yunpeng Zheng, Yuanjing Pu, Kanyi Pramanik, Manojit Xing, Bengang |
| author_sort | Wang, Zhimin |
| collection | NTU |
| description | The emerging photoacoustic imaging (PAI), especially in the NIR window, offers reliable sensing for deep-penetration and high-resolution closing to clinical requirements. However, the contrast agents that are capable of specifically responding to the intricate biological environments, more importantly, indicate promising biodegradability and biocompatibility are still limited. Herein, we introduce a new class of pH-sensitive organic PA contrast agent working in the second near-infrared window (NIR-II, 960 - 1700 nm), which is derived from the self-assembled charge-transfer nanocomplex (CTN) by 3, 3’, 5, 5’-tetramethylbenzidine (TMB) and its dication structure (TMB++). Such unique NIR-II-responsive CTN can specifically respond to pH change in the physiological range, allows noninvasive and sensitive visualization of the tumor acidic microenvironment (e.g. at pH 5) in mice with higher signal-to-noise ratio (SNR). Moreover, this organic CTN demonstrates the biodegradable feature in physiological condition (e.g. at pH 7.4), which provides the great biosafety without the concern of nanoparticles accumulation in vivo. These results clearly show the potential of TMB/TMB++-based CTN as a promising pH-activatable and biodegradable molecular probe for specific tumor photoacoustic imaging in the NIR-II region. |
| first_indexed | 2024-10-01T03:31:46Z |
| format | Journal Article |
| id | ntu-10356/89425 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T03:31:46Z |
| publishDate | 2018 |
| record_format | dspace |
| spelling | ntu-10356/894252023-02-28T19:50:38Z pH-sensitive and biodegradable charge-transfer nanocomplex for second near-infrared photoacoustic tumor imaging Wang, Zhimin Upputuri, Paul Kumar Zhen, Xu Zhang, Ruochong Jiang, Yuyan Ai, Xiangzhao Zhang, Zhijun Hu, Ming Meng, Zhenyu Lu, Yunpeng Zheng, Yuanjing Pu, Kanyi Pramanik, Manojit Xing, Bengang School of Electrical and Electronic Engineering School of Physical and Mathematical Sciences School of Chemical and Biomedical Engineering DRNTU::Science::Chemistry Second Near-infrared Window Charge-transfer Nanocomplex The emerging photoacoustic imaging (PAI), especially in the NIR window, offers reliable sensing for deep-penetration and high-resolution closing to clinical requirements. However, the contrast agents that are capable of specifically responding to the intricate biological environments, more importantly, indicate promising biodegradability and biocompatibility are still limited. Herein, we introduce a new class of pH-sensitive organic PA contrast agent working in the second near-infrared window (NIR-II, 960 - 1700 nm), which is derived from the self-assembled charge-transfer nanocomplex (CTN) by 3, 3’, 5, 5’-tetramethylbenzidine (TMB) and its dication structure (TMB++). Such unique NIR-II-responsive CTN can specifically respond to pH change in the physiological range, allows noninvasive and sensitive visualization of the tumor acidic microenvironment (e.g. at pH 5) in mice with higher signal-to-noise ratio (SNR). Moreover, this organic CTN demonstrates the biodegradable feature in physiological condition (e.g. at pH 7.4), which provides the great biosafety without the concern of nanoparticles accumulation in vivo. These results clearly show the potential of TMB/TMB++-based CTN as a promising pH-activatable and biodegradable molecular probe for specific tumor photoacoustic imaging in the NIR-II region. MOE (Min. of Education, S’pore) NMRC (Natl Medical Research Council, S’pore) Accepted version 2018-12-19T05:39:49Z 2019-12-06T17:25:12Z 2018-12-19T05:39:49Z 2019-12-06T17:25:12Z 2019 2019 Journal Article Wang, Z., Upputuri, P. K., Zhen, X., Zhang, R., Jiang, Y., Ai, X., ... Xing, B. (2019). pH-sensitive and biodegradable charge-transfer nanocomplex for second near-infrared photoacoustic tumor imaging. Nano Research, 12(1), 49-55. doi:10.1007/s12274-018-2175-9 1998-0124 https://hdl.handle.net/10356/89425 http://hdl.handle.net/10220/47098 10.1007/s12274-018-2175-9 209194 en Nano Research © 2019 Tsinghua University Press and Springer. This is the author created version of a work that has been peer reviewed and accepted for publication by Nano Research, Tsinghua University Press and Springer. It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document. The published version is available at: [http://dx.doi.org/10.1007/s12274-018-2175-9]. 13 p. application/pdf |
| spellingShingle | DRNTU::Science::Chemistry Second Near-infrared Window Charge-transfer Nanocomplex Wang, Zhimin Upputuri, Paul Kumar Zhen, Xu Zhang, Ruochong Jiang, Yuyan Ai, Xiangzhao Zhang, Zhijun Hu, Ming Meng, Zhenyu Lu, Yunpeng Zheng, Yuanjing Pu, Kanyi Pramanik, Manojit Xing, Bengang pH-sensitive and biodegradable charge-transfer nanocomplex for second near-infrared photoacoustic tumor imaging |
| title | pH-sensitive and biodegradable charge-transfer nanocomplex for second near-infrared photoacoustic tumor imaging |
| title_full | pH-sensitive and biodegradable charge-transfer nanocomplex for second near-infrared photoacoustic tumor imaging |
| title_fullStr | pH-sensitive and biodegradable charge-transfer nanocomplex for second near-infrared photoacoustic tumor imaging |
| title_full_unstemmed | pH-sensitive and biodegradable charge-transfer nanocomplex for second near-infrared photoacoustic tumor imaging |
| title_short | pH-sensitive and biodegradable charge-transfer nanocomplex for second near-infrared photoacoustic tumor imaging |
| title_sort | ph sensitive and biodegradable charge transfer nanocomplex for second near infrared photoacoustic tumor imaging |
| topic | DRNTU::Science::Chemistry Second Near-infrared Window Charge-transfer Nanocomplex |
| url | https://hdl.handle.net/10356/89425 http://hdl.handle.net/10220/47098 |
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