Nucleosome acidic patch-targeting binuclear ruthenium compounds induce aberrant chromatin condensation
The ‘acidic patch’ is a highly electronegative cleft on the histone H2A–H2B dimer in the nucleosome. It is a fundamental motif for protein binding and chromatin dynamics, but the cellular impact of targeting this potentially therapeutic site with exogenous molecules remains unclear. Here, we charact...
| Principais autores: | , , , , , , , , , , , |
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| Outros Autores: | |
| Formato: | Journal Article |
| Idioma: | English |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://hdl.handle.net/10356/89472 http://hdl.handle.net/10220/44965 |