Serial processing of kinematic signals by cerebellar circuitry during voluntary whisking
Purkinje cells (PCs) in Crus 1 represent whisker movement via linear changes in firing rate, but the circuit mechanisms underlying this coding scheme are unknown. Here we examine the role of upstream inputs to PCs—excitatory granule cells (GCs) and inhibitory molecular layer interneurons—in processi...
| Main Authors: | , , |
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| Format: | Journal Article |
| Language: | English |
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2018
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| Online Access: | https://hdl.handle.net/10356/89516 http://hdl.handle.net/10220/44970 |
| _version_ | 1826117230039924736 |
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| author | Chen, Susu Augustine, George James Chadderton, Paul |
| author2 | Lee Kong Chian School of Medicine (LKCMedicine) |
| author_facet | Lee Kong Chian School of Medicine (LKCMedicine) Chen, Susu Augustine, George James Chadderton, Paul |
| author_sort | Chen, Susu |
| collection | NTU |
| description | Purkinje cells (PCs) in Crus 1 represent whisker movement via linear changes in firing rate, but the circuit mechanisms underlying this coding scheme are unknown. Here we examine the role of upstream inputs to PCs—excitatory granule cells (GCs) and inhibitory molecular layer interneurons—in processing of whisking signals. Patch clamp recordings in GCs reveal that movement is accompanied by changes in mossy fibre input rate that drive membrane potential depolarisation and high-frequency bursting activity at preferred whisker angles. Although individual GCs are narrowly tuned, GC populations provide linear excitatory drive across a wide range of movement. Molecular layer interneurons exhibit bidirectional firing rate changes during whisking, similar to PCs. Together, GC populations provide downstream PCs with linear representations of volitional movement, while inhibitory networks invert these signals. The exquisite sensitivity of neurons at each processing stage enables faithful propagation of kinematic representations through the cerebellum. |
| first_indexed | 2024-10-01T04:24:13Z |
| format | Journal Article |
| id | ntu-10356/89516 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T04:24:13Z |
| publishDate | 2018 |
| record_format | dspace |
| spelling | ntu-10356/895162020-11-01T05:17:22Z Serial processing of kinematic signals by cerebellar circuitry during voluntary whisking Chen, Susu Augustine, George James Chadderton, Paul Lee Kong Chian School of Medicine (LKCMedicine) Neuromodulation Signal Processing Purkinje cells (PCs) in Crus 1 represent whisker movement via linear changes in firing rate, but the circuit mechanisms underlying this coding scheme are unknown. Here we examine the role of upstream inputs to PCs—excitatory granule cells (GCs) and inhibitory molecular layer interneurons—in processing of whisking signals. Patch clamp recordings in GCs reveal that movement is accompanied by changes in mossy fibre input rate that drive membrane potential depolarisation and high-frequency bursting activity at preferred whisker angles. Although individual GCs are narrowly tuned, GC populations provide linear excitatory drive across a wide range of movement. Molecular layer interneurons exhibit bidirectional firing rate changes during whisking, similar to PCs. Together, GC populations provide downstream PCs with linear representations of volitional movement, while inhibitory networks invert these signals. The exquisite sensitivity of neurons at each processing stage enables faithful propagation of kinematic representations through the cerebellum. NRF (Natl Research Foundation, S’pore) Published version 2018-06-06T04:01:05Z 2019-12-06T17:27:27Z 2018-06-06T04:01:05Z 2019-12-06T17:27:27Z 2017 Journal Article Chen, S., Augustine, G. J., & Chadderton, P. (2017). Serial processing of kinematic signals by cerebellar circuitry during voluntary whisking. Nature Communications, 8(1), 232-. 2041-1723 https://hdl.handle.net/10356/89516 http://hdl.handle.net/10220/44970 10.1038/s41467-017-00312-1 en Nature Communications © 2017 The Author(s). This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ 13 p. application/pdf |
| spellingShingle | Neuromodulation Signal Processing Chen, Susu Augustine, George James Chadderton, Paul Serial processing of kinematic signals by cerebellar circuitry during voluntary whisking |
| title | Serial processing of kinematic signals by cerebellar circuitry during voluntary whisking |
| title_full | Serial processing of kinematic signals by cerebellar circuitry during voluntary whisking |
| title_fullStr | Serial processing of kinematic signals by cerebellar circuitry during voluntary whisking |
| title_full_unstemmed | Serial processing of kinematic signals by cerebellar circuitry during voluntary whisking |
| title_short | Serial processing of kinematic signals by cerebellar circuitry during voluntary whisking |
| title_sort | serial processing of kinematic signals by cerebellar circuitry during voluntary whisking |
| topic | Neuromodulation Signal Processing |
| url | https://hdl.handle.net/10356/89516 http://hdl.handle.net/10220/44970 |
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