Irisin is a pro-myogenic factor that induces skeletal muscle hypertrophy and rescues denervation-induced atrophy
Exercise induces expression of the myokine irisin, which is known to promote browning of white adipose tissue and has been shown to mediate beneficial effects following exercise. Here we show that irisin induces expression of a number of pro-myogenic and exercise response genes in myotubes. Irisin i...
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| Format: | Journal Article |
| Sprog: | English |
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2018
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| Online adgang: | https://hdl.handle.net/10356/89519 http://hdl.handle.net/10220/44963 |
| _version_ | 1826120529709367296 |
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| author | Reza, Musarrat Maisha Subramaniyam, Nathiya Sim, Chu Ming Ge, Xiaojia Sathiakumar, Durgalakshmi McFarlane, Craig Sharma, Mridula Kambadur, Ravi |
| author2 | School of Biological Sciences |
| author_facet | School of Biological Sciences Reza, Musarrat Maisha Subramaniyam, Nathiya Sim, Chu Ming Ge, Xiaojia Sathiakumar, Durgalakshmi McFarlane, Craig Sharma, Mridula Kambadur, Ravi |
| author_sort | Reza, Musarrat Maisha |
| collection | NTU |
| description | Exercise induces expression of the myokine irisin, which is known to promote browning of white adipose tissue and has been shown to mediate beneficial effects following exercise. Here we show that irisin induces expression of a number of pro-myogenic and exercise response genes in myotubes. Irisin increases myogenic differentiation and myoblast fusion via activation of IL6 signaling. Injection of irisin in mice induces significant hypertrophy and enhances grip strength of uninjured muscle. Following skeletal muscle injury, irisin injection improves regeneration and induces hypertrophy. The effects of irisin on hypertrophy are due to activation of satellite cells and enhanced protein synthesis. In addition, irisin injection rescues loss of skeletal muscle mass following denervation by enhancing satellite cell activation and reducing protein degradation. These data suggest that irisin functions as a pro-myogenic factor in mice. |
| first_indexed | 2024-10-01T05:17:56Z |
| format | Journal Article |
| id | ntu-10356/89519 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T05:17:56Z |
| publishDate | 2018 |
| record_format | dspace |
| spelling | ntu-10356/895192023-02-28T17:03:01Z Irisin is a pro-myogenic factor that induces skeletal muscle hypertrophy and rescues denervation-induced atrophy Reza, Musarrat Maisha Subramaniyam, Nathiya Sim, Chu Ming Ge, Xiaojia Sathiakumar, Durgalakshmi McFarlane, Craig Sharma, Mridula Kambadur, Ravi School of Biological Sciences Cell Differentiation Pathophysiology Exercise induces expression of the myokine irisin, which is known to promote browning of white adipose tissue and has been shown to mediate beneficial effects following exercise. Here we show that irisin induces expression of a number of pro-myogenic and exercise response genes in myotubes. Irisin increases myogenic differentiation and myoblast fusion via activation of IL6 signaling. Injection of irisin in mice induces significant hypertrophy and enhances grip strength of uninjured muscle. Following skeletal muscle injury, irisin injection improves regeneration and induces hypertrophy. The effects of irisin on hypertrophy are due to activation of satellite cells and enhanced protein synthesis. In addition, irisin injection rescues loss of skeletal muscle mass following denervation by enhancing satellite cell activation and reducing protein degradation. These data suggest that irisin functions as a pro-myogenic factor in mice. ASTAR (Agency for Sci., Tech. and Research, S’pore) NMRC (Natl Medical Research Council, S’pore) Published version 2018-06-05T09:24:43Z 2019-12-06T17:27:30Z 2018-06-05T09:24:43Z 2019-12-06T17:27:30Z 2017 Journal Article Reza, M. M., Subramaniyam, N., Sim, C. M., Ge, X., Sathiakumar, D., McFarlane, C., et al. (2017). Irisin is a pro-myogenic factor that induces skeletal muscle hypertrophy and rescues denervation-induced atrophy. Nature Communications, 8(1), 1104-. 2041-1723 https://hdl.handle.net/10356/89519 http://hdl.handle.net/10220/44963 10.1038/s41467-017-01131-0 en Nature Communications © 2017 The Author(s). This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ 17 p. application/pdf |
| spellingShingle | Cell Differentiation Pathophysiology Reza, Musarrat Maisha Subramaniyam, Nathiya Sim, Chu Ming Ge, Xiaojia Sathiakumar, Durgalakshmi McFarlane, Craig Sharma, Mridula Kambadur, Ravi Irisin is a pro-myogenic factor that induces skeletal muscle hypertrophy and rescues denervation-induced atrophy |
| title | Irisin is a pro-myogenic factor that induces skeletal muscle hypertrophy and rescues denervation-induced atrophy |
| title_full | Irisin is a pro-myogenic factor that induces skeletal muscle hypertrophy and rescues denervation-induced atrophy |
| title_fullStr | Irisin is a pro-myogenic factor that induces skeletal muscle hypertrophy and rescues denervation-induced atrophy |
| title_full_unstemmed | Irisin is a pro-myogenic factor that induces skeletal muscle hypertrophy and rescues denervation-induced atrophy |
| title_short | Irisin is a pro-myogenic factor that induces skeletal muscle hypertrophy and rescues denervation-induced atrophy |
| title_sort | irisin is a pro myogenic factor that induces skeletal muscle hypertrophy and rescues denervation induced atrophy |
| topic | Cell Differentiation Pathophysiology |
| url | https://hdl.handle.net/10356/89519 http://hdl.handle.net/10220/44963 |
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