Crystallographic studies of chromatin-targeting metal-based compounds and nucleosome core particles assembled with engineered cohesive end DNA fragments
In eukaryotic cells, related functions like the storage, protection, and precise regulation of genomic DNA are achieved by its compaction into protein–nucleic acid complex structures known as chromosomes. During the initial steps of compaction, naked DNA is wound around an octamer of histone protein...
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| Format: | Thesis |
| Language: | English |
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2019
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| Online Access: | https://hdl.handle.net/10356/89610 http://hdl.handle.net/10220/47720 |