Establishing a genetically engineered mouse ES cell line expressing an inducible Xist transgene along chromosome 19
Xist (X-inactive specific transcript) RNA plays an important role in X chromosome inactivation (XCI), a dosage compensation mechanism mammalian females have evolved to transcriptionally silence one of two copies of X chromosomes they carry. Xist RNA remains in the nucleus, and during XCI onset, it i...
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| Format: | Thesis |
| Language: | English |
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2018
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| Online Access: | https://hdl.handle.net/10356/89676 http://hdl.handle.net/10220/46341 |