High-speed, low-cost, pulsed laser diode based second generation desktop photoacoustic tomography system
Bulky, expensive Nd:YAG lasers are used in conventional photoacoustic tomography (PAT) systems making them difficult to translate into clinics. Moreover, real-time imaging is not feasible when single-element ultrasound transducer is used with these low pulse repetition rate lasers (10-100 Hz). Low-c...
| Main Authors: | , , |
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| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
| Published: |
2018
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| Online Access: | https://hdl.handle.net/10356/89719 http://hdl.handle.net/10220/47242 |
| _version_ | 1811676413784227840 |
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| author | Kalva, Sandeep Kumar Upputuri, Paul Kumar Pramanik, Manojit |
| author2 | School of Chemical and Biomedical Engineering |
| author_facet | School of Chemical and Biomedical Engineering Kalva, Sandeep Kumar Upputuri, Paul Kumar Pramanik, Manojit |
| author_sort | Kalva, Sandeep Kumar |
| collection | NTU |
| description | Bulky, expensive Nd:YAG lasers are used in conventional photoacoustic tomography (PAT) systems making them difficult to translate into clinics. Moreover, real-time imaging is not feasible when single-element ultrasound transducer is used with these low pulse repetition rate lasers (10-100 Hz). Low-cost pulsed laser diodes (PLD) can be used instead for photoacoustic imaging due to their high pulse repetition rates and compact size. Together with acoustic reflector based multiple single element ultrasound transducers portable desktop PAT system was developed. This second generation pulsed laser diode based photoacoustic tomography (PLD-PAT-G2) achieved 0.5 s cross-sectional imaging time with a high spatial resolution of ~165 m and an imaging depth of 3 cm. The performance of this system was characterized using phantom and in vivo studies. Dynamic in vivo imaging was also demonstrated by monitoring the fast uptake and clearance of indocyanine green in small animal (rat) brain vasculature. |
| first_indexed | 2024-10-01T02:21:05Z |
| format | Journal Article |
| id | ntu-10356/89719 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T02:21:05Z |
| publishDate | 2018 |
| record_format | dspace |
| spelling | ntu-10356/897192023-12-29T06:45:06Z High-speed, low-cost, pulsed laser diode based second generation desktop photoacoustic tomography system Kalva, Sandeep Kumar Upputuri, Paul Kumar Pramanik, Manojit School of Chemical and Biomedical Engineering Photoacoustic Imaging Low-cost Pulsed Laser Diodes DRNTU::Science::Medicine::Biomedical engineering Bulky, expensive Nd:YAG lasers are used in conventional photoacoustic tomography (PAT) systems making them difficult to translate into clinics. Moreover, real-time imaging is not feasible when single-element ultrasound transducer is used with these low pulse repetition rate lasers (10-100 Hz). Low-cost pulsed laser diodes (PLD) can be used instead for photoacoustic imaging due to their high pulse repetition rates and compact size. Together with acoustic reflector based multiple single element ultrasound transducers portable desktop PAT system was developed. This second generation pulsed laser diode based photoacoustic tomography (PLD-PAT-G2) achieved 0.5 s cross-sectional imaging time with a high spatial resolution of ~165 m and an imaging depth of 3 cm. The performance of this system was characterized using phantom and in vivo studies. Dynamic in vivo imaging was also demonstrated by monitoring the fast uptake and clearance of indocyanine green in small animal (rat) brain vasculature. NMRC (Natl Medical Research Council, S’pore) Accepted version 2018-12-27T05:29:19Z 2019-12-06T17:31:55Z 2018-12-27T05:29:19Z 2019-12-06T17:31:55Z 2019 2019 Journal Article Kalva, S. K., Upputuri, P. K., & Pramanik, M. (2019). High-speed, low-cost, pulsed laser diode based second generation desktop photoacoustic tomography system. Optics Letters, 44(1), 81-84. doi:10.1364/OL.44.000081 0146-9592 https://hdl.handle.net/10356/89719 http://hdl.handle.net/10220/47242 10.1364/OL.44.000081 209204 en Optics Letters © 2019 Optical Society of America (OSA). This is the author created version of a work that has been peer reviewed and accepted for publication by Optics Letters, Optical Society of America (OSA). It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document. The published version is available at: [http://dx.doi.org/10.1364/OL.44.000081]. 5 p. application/pdf |
| spellingShingle | Photoacoustic Imaging Low-cost Pulsed Laser Diodes DRNTU::Science::Medicine::Biomedical engineering Kalva, Sandeep Kumar Upputuri, Paul Kumar Pramanik, Manojit High-speed, low-cost, pulsed laser diode based second generation desktop photoacoustic tomography system |
| title | High-speed, low-cost, pulsed laser diode based second generation desktop photoacoustic tomography system |
| title_full | High-speed, low-cost, pulsed laser diode based second generation desktop photoacoustic tomography system |
| title_fullStr | High-speed, low-cost, pulsed laser diode based second generation desktop photoacoustic tomography system |
| title_full_unstemmed | High-speed, low-cost, pulsed laser diode based second generation desktop photoacoustic tomography system |
| title_short | High-speed, low-cost, pulsed laser diode based second generation desktop photoacoustic tomography system |
| title_sort | high speed low cost pulsed laser diode based second generation desktop photoacoustic tomography system |
| topic | Photoacoustic Imaging Low-cost Pulsed Laser Diodes DRNTU::Science::Medicine::Biomedical engineering |
| url | https://hdl.handle.net/10356/89719 http://hdl.handle.net/10220/47242 |
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