Differences in clinical features and dengue severity between local and migrant Chinese with dengue infection in Singapore
Dengue is endemic in Singapore but not China. We compared clinical features and disease severity of dengue between local and migrant Chinese, most of whom were construction workers, in Singapore. A retrospective study with all hospitalized dengue patients from 2005 to 2008 were performed, including...
| Main Authors: | , , , , |
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| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
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2018
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| Online Access: | https://hdl.handle.net/10356/89733 http://hdl.handle.net/10220/46350 |
| _version_ | 1826125885939384320 |
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| author | Xu, Chuanhui Pang, Junxiong Hsu, Jung Pu Leo, Yee Sin Lye, David Chien Boon |
| author2 | Roques, Pierre |
| author_facet | Roques, Pierre Xu, Chuanhui Pang, Junxiong Hsu, Jung Pu Leo, Yee Sin Lye, David Chien Boon |
| author_sort | Xu, Chuanhui |
| collection | NTU |
| description | Dengue is endemic in Singapore but not China. We compared clinical features and disease severity of dengue between local and migrant Chinese, most of whom were construction workers, in Singapore. A retrospective study with all hospitalized dengue patients from 2005 to 2008 were performed, including 2609 local and 1195 migrant Chinese. Compared with local Chinese, migrant Chinese were younger. There were more males, but fewer had comorbidities. Migrant Chinese had more headache, eye pain, nausea and myalgia. They had significantly lower median leukocyte count, ALT and AST, and higher platelet count nadir. Among warning signs, migrant Chinese had significantly less persistent vomiting, clinical fluid accumulation, hepatomegaly, hematocrit rise with rapid platelet drop, and more mucosal bleeding. Adjusted for age, gender and comorbidities, migrant Chinese were significantly at higher risk of dengue hemorrhagic fever (DHF) (adjusted odds ratio [aOR]: 1.20, 95% confidence interval [CI]: 1.03–1.41) and dengue shock syndrome (aOR: 1.49, 95% CI: 1.06–2.10), and had longer hospitalization (β coefficient value: 0.27, 95%CI: 0.09–0.44, p = 0.003). There was 1 death among migrant Chinese and 2 deaths among local Chinese. We documented differences in clinical and laboratory features, and dengue severity between local and migrant Chinese in Singapore. Migrant Chinese may need more medical attention given higher risk of DHF. |
| first_indexed | 2024-10-01T06:43:42Z |
| format | Journal Article |
| id | ntu-10356/89733 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T06:43:42Z |
| publishDate | 2018 |
| record_format | dspace |
| spelling | ntu-10356/897332020-11-01T05:25:17Z Differences in clinical features and dengue severity between local and migrant Chinese with dengue infection in Singapore Xu, Chuanhui Pang, Junxiong Hsu, Jung Pu Leo, Yee Sin Lye, David Chien Boon Roques, Pierre Lee Kong Chian School of Medicine (LKCMedicine) DRNTU::Science::Medicine Clinical Features Dengue Severity Dengue is endemic in Singapore but not China. We compared clinical features and disease severity of dengue between local and migrant Chinese, most of whom were construction workers, in Singapore. A retrospective study with all hospitalized dengue patients from 2005 to 2008 were performed, including 2609 local and 1195 migrant Chinese. Compared with local Chinese, migrant Chinese were younger. There were more males, but fewer had comorbidities. Migrant Chinese had more headache, eye pain, nausea and myalgia. They had significantly lower median leukocyte count, ALT and AST, and higher platelet count nadir. Among warning signs, migrant Chinese had significantly less persistent vomiting, clinical fluid accumulation, hepatomegaly, hematocrit rise with rapid platelet drop, and more mucosal bleeding. Adjusted for age, gender and comorbidities, migrant Chinese were significantly at higher risk of dengue hemorrhagic fever (DHF) (adjusted odds ratio [aOR]: 1.20, 95% confidence interval [CI]: 1.03–1.41) and dengue shock syndrome (aOR: 1.49, 95% CI: 1.06–2.10), and had longer hospitalization (β coefficient value: 0.27, 95%CI: 0.09–0.44, p = 0.003). There was 1 death among migrant Chinese and 2 deaths among local Chinese. We documented differences in clinical and laboratory features, and dengue severity between local and migrant Chinese in Singapore. Migrant Chinese may need more medical attention given higher risk of DHF. Published version 2018-10-17T03:48:26Z 2019-12-06T17:32:12Z 2018-10-17T03:48:26Z 2019-12-06T17:32:12Z 2018 Journal Article Xu, C., Pang, J., Hsu, J. P., Leo, Y. S., & Lye, D. C. B. (2018). Differences in clinical features and dengue severity between local and migrant Chinese with dengue infection in Singapore. PLOS ONE, 13(8), e0201441-. doi:10.1371/journal.pone.0201441 https://hdl.handle.net/10356/89733 http://hdl.handle.net/10220/46350 10.1371/journal.pone.0201441 en PLOS ONE © 2018 Xu et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. 10 p. application/pdf |
| spellingShingle | DRNTU::Science::Medicine Clinical Features Dengue Severity Xu, Chuanhui Pang, Junxiong Hsu, Jung Pu Leo, Yee Sin Lye, David Chien Boon Differences in clinical features and dengue severity between local and migrant Chinese with dengue infection in Singapore |
| title | Differences in clinical features and dengue severity between local and migrant Chinese with dengue infection in Singapore |
| title_full | Differences in clinical features and dengue severity between local and migrant Chinese with dengue infection in Singapore |
| title_fullStr | Differences in clinical features and dengue severity between local and migrant Chinese with dengue infection in Singapore |
| title_full_unstemmed | Differences in clinical features and dengue severity between local and migrant Chinese with dengue infection in Singapore |
| title_short | Differences in clinical features and dengue severity between local and migrant Chinese with dengue infection in Singapore |
| title_sort | differences in clinical features and dengue severity between local and migrant chinese with dengue infection in singapore |
| topic | DRNTU::Science::Medicine Clinical Features Dengue Severity |
| url | https://hdl.handle.net/10356/89733 http://hdl.handle.net/10220/46350 |
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