Bioengineering of metal-organic frameworks for nanomedicine
Controlled structure, tunable porosity, and readily chemical functionalizability make metal-organic frameworks (MOFs) a powerful biomedical tool. Nanoscale MOF particles have been increasingly studied as drug carriers, bioimaging agents, and therapeutic agents due to their excellent physiochemical p...
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| Format: | Journal Article |
| Language: | English |
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2019
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| Online Access: | https://hdl.handle.net/10356/89741 http://hdl.handle.net/10220/49327 |
| _version_ | 1826126392381669376 |
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| author | Liu, Yuan Zhao, Yanli Chen, Xiaoyuan |
| author2 | School of Physical and Mathematical Sciences |
| author_facet | School of Physical and Mathematical Sciences Liu, Yuan Zhao, Yanli Chen, Xiaoyuan |
| author_sort | Liu, Yuan |
| collection | NTU |
| description | Controlled structure, tunable porosity, and readily chemical functionalizability make metal-organic frameworks (MOFs) a powerful biomedical tool. Nanoscale MOF particles have been increasingly studied as drug carriers, bioimaging agents, and therapeutic agents due to their excellent physiochemical properties. In this review, we start with MOF as a nanocarrier for drug delivery, covering therapeutic MOF agents followed by a comprehensive discussion of surface bioengineering of MOF for improved biostability, biocompatibility, and targeted delivery. Finally, we detail the challenges and prospects of the future of MOF research for biomedical applications. |
| first_indexed | 2024-10-01T06:51:55Z |
| format | Journal Article |
| id | ntu-10356/89741 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T06:51:55Z |
| publishDate | 2019 |
| record_format | dspace |
| spelling | ntu-10356/897412023-02-28T19:32:30Z Bioengineering of metal-organic frameworks for nanomedicine Liu, Yuan Zhao, Yanli Chen, Xiaoyuan School of Physical and Mathematical Sciences Metal-organic Frameworks Drug Delivery Science::Chemistry Controlled structure, tunable porosity, and readily chemical functionalizability make metal-organic frameworks (MOFs) a powerful biomedical tool. Nanoscale MOF particles have been increasingly studied as drug carriers, bioimaging agents, and therapeutic agents due to their excellent physiochemical properties. In this review, we start with MOF as a nanocarrier for drug delivery, covering therapeutic MOF agents followed by a comprehensive discussion of surface bioengineering of MOF for improved biostability, biocompatibility, and targeted delivery. Finally, we detail the challenges and prospects of the future of MOF research for biomedical applications. Published version 2019-07-12T05:07:50Z 2019-12-06T17:32:25Z 2019-07-12T05:07:50Z 2019-12-06T17:32:25Z 2019 Journal Article Liu, Y., Zhao, Y., & Chen, X. (2019). Bioengineering of Metal-organic Frameworks for Nanomedicine. Theranostics, 9(11), 3122-3133. doi:10.7150/thno.31918 https://hdl.handle.net/10356/89741 http://hdl.handle.net/10220/49327 10.7150/thno.31918 en Theranostics © 2019 Ivyspring International Publisher. This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) license (https://creativecommons.org/licenses/by-nc/4.0/). See http://ivyspring.com/terms for full terms and conditions. 12 p. application/pdf |
| spellingShingle | Metal-organic Frameworks Drug Delivery Science::Chemistry Liu, Yuan Zhao, Yanli Chen, Xiaoyuan Bioengineering of metal-organic frameworks for nanomedicine |
| title | Bioengineering of metal-organic frameworks for nanomedicine |
| title_full | Bioengineering of metal-organic frameworks for nanomedicine |
| title_fullStr | Bioengineering of metal-organic frameworks for nanomedicine |
| title_full_unstemmed | Bioengineering of metal-organic frameworks for nanomedicine |
| title_short | Bioengineering of metal-organic frameworks for nanomedicine |
| title_sort | bioengineering of metal organic frameworks for nanomedicine |
| topic | Metal-organic Frameworks Drug Delivery Science::Chemistry |
| url | https://hdl.handle.net/10356/89741 http://hdl.handle.net/10220/49327 |
| work_keys_str_mv | AT liuyuan bioengineeringofmetalorganicframeworksfornanomedicine AT zhaoyanli bioengineeringofmetalorganicframeworksfornanomedicine AT chenxiaoyuan bioengineeringofmetalorganicframeworksfornanomedicine |