Determinants for tuberculosis in HIV-infected adults in Northwest Ethiopia : a multicentre case–control study
Objective: The objective of this study was to identify determinants for tuberculosis (TB) among HIV-infected adults in Northwest Ethiopia. Design: Case–control study. Setting: Three hospitals and 10 health centres in Northwest Ethiopia. Participants: A total of 446 individuals consented to participa...
| Main Authors: | , , |
|---|---|
| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
| Published: |
2018
|
| Subjects: | |
| Online Access: | https://hdl.handle.net/10356/89928 http://hdl.handle.net/10220/46468 |
| _version_ | 1811681143170269184 |
|---|---|
| author | Alemu, Yihun Mulugeta Awoke, Worku Wilder-Smith, Annalies |
| author2 | Lee Kong Chian School of Medicine (LKCMedicine) |
| author_facet | Lee Kong Chian School of Medicine (LKCMedicine) Alemu, Yihun Mulugeta Awoke, Worku Wilder-Smith, Annalies |
| author_sort | Alemu, Yihun Mulugeta |
| collection | NTU |
| description | Objective: The objective of this study was to identify determinants for tuberculosis (TB) among HIV-infected adults in Northwest Ethiopia. Design: Case–control study. Setting: Three hospitals and 10 health centres in Northwest Ethiopia. Participants: A total of 446 individuals consented to participate in the study (150 cases and 296 controls). Cases were HIV-infected adults diagnosed with active TB, and controls were HIV-infected adults without active TB. Main outcome measure: The link between TB and determinants was assessed using logistic regression. Determinants were categorised as sociodemographic, host-related, clinical and environmental. Results: Smoking (adjusted OR (AOR) 5.47; 95% CI 2.26 to 13.22), presence of a TB patient in the family (AOR 2.66; 95% CI 1.25 to 5.66), alcohol consumption (AOR 2.49; 95% CI 1.29 to 4.80) and chewing khat (AOR 2.22; 95% CI 1.11 to 4.41) were independent determinants for increased occurrence of TB. Highly active antiretroviral therapy (HAART) (AOR 0.25; 95% CI 0.13 to 0.51), isoniazid preventive therapy (IPT) (AOR 0.22; 95% CI 0.11 to 0.41) and cotrimoxazole preventive therapy (AOR 0.32; 95% CI 0.19 to 0.55) had a protective effect against TB. Conclusions: HIV-infected adults with substance abuse (tobacco smoking, khat chewing and alcohol) should be prioritised for TB screening. This study reaffirmed that HAART and IPT are some of the best strategies for reducing TB occurrence in HIV-infected adults. These findings provide impetus to intensify tracing of TB household contacts. |
| first_indexed | 2024-10-01T03:36:15Z |
| format | Journal Article |
| id | ntu-10356/89928 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T03:36:15Z |
| publishDate | 2018 |
| record_format | dspace |
| spelling | ntu-10356/899282022-02-16T16:29:11Z Determinants for tuberculosis in HIV-infected adults in Northwest Ethiopia : a multicentre case–control study Alemu, Yihun Mulugeta Awoke, Worku Wilder-Smith, Annalies Lee Kong Chian School of Medicine (LKCMedicine) Tuberculosis HIV-infected Adults DRNTU::Science::Medicine Objective: The objective of this study was to identify determinants for tuberculosis (TB) among HIV-infected adults in Northwest Ethiopia. Design: Case–control study. Setting: Three hospitals and 10 health centres in Northwest Ethiopia. Participants: A total of 446 individuals consented to participate in the study (150 cases and 296 controls). Cases were HIV-infected adults diagnosed with active TB, and controls were HIV-infected adults without active TB. Main outcome measure: The link between TB and determinants was assessed using logistic regression. Determinants were categorised as sociodemographic, host-related, clinical and environmental. Results: Smoking (adjusted OR (AOR) 5.47; 95% CI 2.26 to 13.22), presence of a TB patient in the family (AOR 2.66; 95% CI 1.25 to 5.66), alcohol consumption (AOR 2.49; 95% CI 1.29 to 4.80) and chewing khat (AOR 2.22; 95% CI 1.11 to 4.41) were independent determinants for increased occurrence of TB. Highly active antiretroviral therapy (HAART) (AOR 0.25; 95% CI 0.13 to 0.51), isoniazid preventive therapy (IPT) (AOR 0.22; 95% CI 0.11 to 0.41) and cotrimoxazole preventive therapy (AOR 0.32; 95% CI 0.19 to 0.55) had a protective effect against TB. Conclusions: HIV-infected adults with substance abuse (tobacco smoking, khat chewing and alcohol) should be prioritised for TB screening. This study reaffirmed that HAART and IPT are some of the best strategies for reducing TB occurrence in HIV-infected adults. These findings provide impetus to intensify tracing of TB household contacts. Published version 2018-10-29T08:52:23Z 2019-12-06T17:36:47Z 2018-10-29T08:52:23Z 2019-12-06T17:36:47Z 2016 Journal Article Alemu, Y. M., Awoke, W., & Wilder-Smith, A. (2016). Determinants for tuberculosis in HIV-infected adults in Northwest Ethiopia : a multicentre case–control study. BMJ Open, 6(4), e009058-. doi:10.1136/bmjopen-2015-009058 https://hdl.handle.net/10356/89928 http://hdl.handle.net/10220/46468 10.1136/bmjopen-2015-009058 27084271 en BMJ Open © 2016 The Author(s) (published by BMJ Publishing Group). This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ 6 p. application/pdf |
| spellingShingle | Tuberculosis HIV-infected Adults DRNTU::Science::Medicine Alemu, Yihun Mulugeta Awoke, Worku Wilder-Smith, Annalies Determinants for tuberculosis in HIV-infected adults in Northwest Ethiopia : a multicentre case–control study |
| title | Determinants for tuberculosis in HIV-infected adults in Northwest Ethiopia : a multicentre case–control study |
| title_full | Determinants for tuberculosis in HIV-infected adults in Northwest Ethiopia : a multicentre case–control study |
| title_fullStr | Determinants for tuberculosis in HIV-infected adults in Northwest Ethiopia : a multicentre case–control study |
| title_full_unstemmed | Determinants for tuberculosis in HIV-infected adults in Northwest Ethiopia : a multicentre case–control study |
| title_short | Determinants for tuberculosis in HIV-infected adults in Northwest Ethiopia : a multicentre case–control study |
| title_sort | determinants for tuberculosis in hiv infected adults in northwest ethiopia a multicentre case control study |
| topic | Tuberculosis HIV-infected Adults DRNTU::Science::Medicine |
| url | https://hdl.handle.net/10356/89928 http://hdl.handle.net/10220/46468 |
| work_keys_str_mv | AT alemuyihunmulugeta determinantsfortuberculosisinhivinfectedadultsinnorthwestethiopiaamulticentrecasecontrolstudy AT awokeworku determinantsfortuberculosisinhivinfectedadultsinnorthwestethiopiaamulticentrecasecontrolstudy AT wildersmithannalies determinantsfortuberculosisinhivinfectedadultsinnorthwestethiopiaamulticentrecasecontrolstudy |