In vitro pre-vascularization strategies for tissue engineered constructs – bioprinting and others
Tissue-engineered products commercially available today have been limited to thin avascular tissue such as skin and cartilage. The fabrication of thicker, more complex tissue still eludes scientists today. One reason for this is the lack of effective techniques to incorporate functional vascular net...
| Main Authors: | , |
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| Format: | Journal Article |
| Language: | English |
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2018
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| Online Access: | https://hdl.handle.net/10356/89963 http://hdl.handle.net/10220/47173 |
| _version_ | 1811677356308299776 |
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| author | Liew, Andy Wen Loong Zhang, Yilei |
| author2 | School of Mechanical and Aerospace Engineering |
| author_facet | School of Mechanical and Aerospace Engineering Liew, Andy Wen Loong Zhang, Yilei |
| author_sort | Liew, Andy Wen Loong |
| collection | NTU |
| description | Tissue-engineered products commercially available today have been limited to thin avascular tissue such as skin and cartilage. The fabrication of thicker, more complex tissue still eludes scientists today. One reason for this is the lack of effective techniques to incorporate functional vascular networks within thick tissue constructs. Vascular networks provide cells throughout the tissue with adequate oxygen and nutrients; cells located within thick un-vascularized tissue implants eventually die due to oxygen and nutrient deficiency. Vascularization has been identified as one of the key components in the field of tissue engineering. In order to fabricate biomimetic tissue which accurately recapitulates our native tissue environment, in vitro pre-vascularization strategies need to be developed. In this review, we describe various in vitro vascularization techniques developed recently which employ different technologies such as bioprinting, microfluidics, micropatterning, wire molding, and cell sheet engineering. We describe the fabrication process and unique characteristics of each technique, as well as provide our perspective on the future of the field. |
| first_indexed | 2024-10-01T02:36:04Z |
| format | Journal Article |
| id | ntu-10356/89963 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T02:36:04Z |
| publishDate | 2018 |
| record_format | dspace |
| spelling | ntu-10356/899632023-03-04T17:17:08Z In vitro pre-vascularization strategies for tissue engineered constructs – bioprinting and others Liew, Andy Wen Loong Zhang, Yilei School of Mechanical and Aerospace Engineering Singapore Centre for 3D Printing Pre-vascularization DRNTU::Engineering::Mechanical engineering Bio-printing Tissue-engineered products commercially available today have been limited to thin avascular tissue such as skin and cartilage. The fabrication of thicker, more complex tissue still eludes scientists today. One reason for this is the lack of effective techniques to incorporate functional vascular networks within thick tissue constructs. Vascular networks provide cells throughout the tissue with adequate oxygen and nutrients; cells located within thick un-vascularized tissue implants eventually die due to oxygen and nutrient deficiency. Vascularization has been identified as one of the key components in the field of tissue engineering. In order to fabricate biomimetic tissue which accurately recapitulates our native tissue environment, in vitro pre-vascularization strategies need to be developed. In this review, we describe various in vitro vascularization techniques developed recently which employ different technologies such as bioprinting, microfluidics, micropatterning, wire molding, and cell sheet engineering. We describe the fabrication process and unique characteristics of each technique, as well as provide our perspective on the future of the field. ASTAR (Agency for Sci., Tech. and Research, S’pore) MOE (Min. of Education, S’pore) Published version 2018-12-21T06:31:01Z 2019-12-06T17:37:34Z 2018-12-21T06:31:01Z 2019-12-06T17:37:34Z 2017 Journal Article Liew, A. W. L., & Zhang, Y. (2017). In vitro pre-vascularization strategies for tissue engineered constructs – bioprinting and others. International Journal of Bioprinting, 3(1), 3-17. doi:10.18063/IJB.2017.01.008 https://hdl.handle.net/10356/89963 http://hdl.handle.net/10220/47173 10.18063/IJB.2017.01.008 en International Journal of Bioprinting © 2017 Andy Wen Loong Liew. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons. org/licenses/by-nc/4.0/), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. 15 p. application/pdf |
| spellingShingle | Pre-vascularization DRNTU::Engineering::Mechanical engineering Bio-printing Liew, Andy Wen Loong Zhang, Yilei In vitro pre-vascularization strategies for tissue engineered constructs – bioprinting and others |
| title | In vitro pre-vascularization strategies for tissue engineered constructs – bioprinting and others |
| title_full | In vitro pre-vascularization strategies for tissue engineered constructs – bioprinting and others |
| title_fullStr | In vitro pre-vascularization strategies for tissue engineered constructs – bioprinting and others |
| title_full_unstemmed | In vitro pre-vascularization strategies for tissue engineered constructs – bioprinting and others |
| title_short | In vitro pre-vascularization strategies for tissue engineered constructs – bioprinting and others |
| title_sort | in vitro pre vascularization strategies for tissue engineered constructs bioprinting and others |
| topic | Pre-vascularization DRNTU::Engineering::Mechanical engineering Bio-printing |
| url | https://hdl.handle.net/10356/89963 http://hdl.handle.net/10220/47173 |
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