Autonomous in vitro anticancer drug release from mesoporous silica nanoparticles by pH-sensitive nanovalves
Mesoporous silica nanoparticles (MSNP) have proven to be an extremely effective solid support for controlled drug delivery on account of the fact that their surfaces can be...
| Main Authors: | , , , , , , , |
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| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
| Published: |
2011
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10356/93792 http://hdl.handle.net/10220/7048 |
| _version_ | 1826121658347290624 |
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| author | Nel, Andre E. Zink, Jeffrey I. Meng, Huan Xue, Min Xia, Tian Zhao, Yanli Tamanoi, Fuyuhiko Stoddart, J. Fraser |
| author2 | School of Physical and Mathematical Sciences |
| author_facet | School of Physical and Mathematical Sciences Nel, Andre E. Zink, Jeffrey I. Meng, Huan Xue, Min Xia, Tian Zhao, Yanli Tamanoi, Fuyuhiko Stoddart, J. Fraser |
| author_sort | Nel, Andre E. |
| collection | NTU |
| description | Mesoporous silica nanoparticles (MSNP) have proven to be an extremely effective solid support
for controlled drug delivery on account of the fact that their surfaces can be easily functionalized in order
to control the nanopore openings. We have described recently a series of mechanized silica nanoparticles,
which, under abiotic conditions, are capable of delivering cargo molecules employing a series of nanovalves.
The key question for these systems has now become whether they can be adapted for biological use
through controlled nanovalve opening in cells. Herein, we report a novel MSNP delivery system capable
of drug delivery based on the function of -cyclodextrin ( -CD) nanovalves that are responsive to the
endosomal acidification conditions in human differentiated myeloid (THP-1) and squamous carcinoma (KB-
31) cell lines. Furthermore, we demonstrate how to optimize the surface functionalization of the MSNP so
as to provide a platform for the effective and rapid doxorubicin release to the nuclei of KB-31 cells. |
| first_indexed | 2024-10-01T05:36:07Z |
| format | Journal Article |
| id | ntu-10356/93792 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T05:36:07Z |
| publishDate | 2011 |
| record_format | dspace |
| spelling | ntu-10356/937922022-02-16T16:30:22Z Autonomous in vitro anticancer drug release from mesoporous silica nanoparticles by pH-sensitive nanovalves Nel, Andre E. Zink, Jeffrey I. Meng, Huan Xue, Min Xia, Tian Zhao, Yanli Tamanoi, Fuyuhiko Stoddart, J. Fraser School of Physical and Mathematical Sciences DRNTU::Science::Biological sciences::Biochemistry Mesoporous silica nanoparticles (MSNP) have proven to be an extremely effective solid support for controlled drug delivery on account of the fact that their surfaces can be easily functionalized in order to control the nanopore openings. We have described recently a series of mechanized silica nanoparticles, which, under abiotic conditions, are capable of delivering cargo molecules employing a series of nanovalves. The key question for these systems has now become whether they can be adapted for biological use through controlled nanovalve opening in cells. Herein, we report a novel MSNP delivery system capable of drug delivery based on the function of -cyclodextrin ( -CD) nanovalves that are responsive to the endosomal acidification conditions in human differentiated myeloid (THP-1) and squamous carcinoma (KB- 31) cell lines. Furthermore, we demonstrate how to optimize the surface functionalization of the MSNP so as to provide a platform for the effective and rapid doxorubicin release to the nuclei of KB-31 cells. 2011-09-14T07:17:04Z 2019-12-06T18:45:40Z 2011-09-14T07:17:04Z 2019-12-06T18:45:40Z 2010 2010 Journal Article Meng, H., Xue, M., Xia, T., Zhao, Y. L., Tamanoi, F., Stoddart, J. F., & et al. (2010). Autonomous in Vitro Anticancer Drug Release from Mesoporous Silica Nanoparticles by pH-Sensitive Nanovalves. Journal of the American Chemical Society, 132(36), 12690-12697. 0002-7863 https://hdl.handle.net/10356/93792 http://hdl.handle.net/10220/7048 10.1021/ja104501a 20718462 159765 en Journal of the American chemical society © 2010 American Chemical Society 8 p. |
| spellingShingle | DRNTU::Science::Biological sciences::Biochemistry Nel, Andre E. Zink, Jeffrey I. Meng, Huan Xue, Min Xia, Tian Zhao, Yanli Tamanoi, Fuyuhiko Stoddart, J. Fraser Autonomous in vitro anticancer drug release from mesoporous silica nanoparticles by pH-sensitive nanovalves |
| title | Autonomous in vitro anticancer drug release from mesoporous silica nanoparticles by pH-sensitive nanovalves |
| title_full | Autonomous in vitro anticancer drug release from mesoporous silica nanoparticles by pH-sensitive nanovalves |
| title_fullStr | Autonomous in vitro anticancer drug release from mesoporous silica nanoparticles by pH-sensitive nanovalves |
| title_full_unstemmed | Autonomous in vitro anticancer drug release from mesoporous silica nanoparticles by pH-sensitive nanovalves |
| title_short | Autonomous in vitro anticancer drug release from mesoporous silica nanoparticles by pH-sensitive nanovalves |
| title_sort | autonomous in vitro anticancer drug release from mesoporous silica nanoparticles by ph sensitive nanovalves |
| topic | DRNTU::Science::Biological sciences::Biochemistry |
| url | https://hdl.handle.net/10356/93792 http://hdl.handle.net/10220/7048 |
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