Solution structure of the antiapoptotic protein bcl-2
The structures of two isoforms of Bcl-2 that differ by two amino acids have been determined by NMR spectroscopy. Because wild-type Bcl-2 behaved poorly in solution, the structures were determined by using Bcl-2/Bcl-xL chimeras in which part of the putative unstructured loop of Bcl-2 was replaced wit...
Main Authors: | Petros, Andrew M., Nettesheim, David G., Kim, Daniel H., Matayoshi, Edmund D., Fesik, Stephen W., Medek, Ales, Yoon, Ho Sup, Swift, Kerry, Oltersdorf, Tilman |
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Other Authors: | School of Biological Sciences |
Format: | Conference Paper |
Language: | English |
Published: |
2012
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Subjects: | |
Online Access: | https://hdl.handle.net/10356/94051 http://hdl.handle.net/10220/7509 |
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