On DNA modelling : interaction of a double helicoidal structure with viscous bio-fluid
The paper aims at extending, utilising and generalising research in nonlinear dynamics of (i) spiral/helicoidal structures, and (ii) viscous, low speed fluid to biomechanical DNA fluidstructure interaction. Employing a nonlinear helicoidal model, the energy stored in a distorted Watso...
| Main Authors: | , |
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| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
| Published: |
2011
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| Online Access: | https://hdl.handle.net/10356/94086 http://hdl.handle.net/10220/7224 |
| _version_ | 1811679819679662080 |
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| author | Shu, Jian Jun Lim, C. W. |
| author2 | School of Mechanical and Aerospace Engineering |
| author_facet | School of Mechanical and Aerospace Engineering Shu, Jian Jun Lim, C. W. |
| author_sort | Shu, Jian Jun |
| collection | NTU |
| description | The paper aims at extending, utilising and generalising research in nonlinear dynamics of (i) spiral/helicoidal structures, and (ii) viscous, low speed fluid to biomechanical DNA fluidstructure
interaction. Employing a nonlinear helicoidal model, the energy stored in a distorted Watson-Crick DNA model subjected to viscous, low speed organic fluid loading is formulated. Numerical solutions based on the variational principle are presented for a
linearized flow field as examples. Significant dynamical responses such as deformation components and resultants are discussed. A proposal for matching of DNA sequential characteristics with respect to the nonlinear dynamical responses is outlined in order to reveal information regarding DNA sequencing by means of a fluid-structure dynamical approach. |
| first_indexed | 2024-10-01T03:15:13Z |
| format | Journal Article |
| id | ntu-10356/94086 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T03:15:13Z |
| publishDate | 2011 |
| record_format | dspace |
| spelling | ntu-10356/940862019-12-06T18:50:26Z On DNA modelling : interaction of a double helicoidal structure with viscous bio-fluid Shu, Jian Jun Lim, C. W. School of Mechanical and Aerospace Engineering City University of Hong Kong DRNTU::Engineering::Mechanical engineering::Bio-mechatronics The paper aims at extending, utilising and generalising research in nonlinear dynamics of (i) spiral/helicoidal structures, and (ii) viscous, low speed fluid to biomechanical DNA fluidstructure interaction. Employing a nonlinear helicoidal model, the energy stored in a distorted Watson-Crick DNA model subjected to viscous, low speed organic fluid loading is formulated. Numerical solutions based on the variational principle are presented for a linearized flow field as examples. Significant dynamical responses such as deformation components and resultants are discussed. A proposal for matching of DNA sequential characteristics with respect to the nonlinear dynamical responses is outlined in order to reveal information regarding DNA sequencing by means of a fluid-structure dynamical approach. Accepted version 2011-10-11T08:04:13Z 2019-12-06T18:50:26Z 2011-10-11T08:04:13Z 2019-12-06T18:50:26Z 2001 2001 Journal Article Lim, C. W. & Shu, J. J. (2001). On DNA modelling: Interaction of a double helicoidal structure with viscous bio-fluid. Automedica, 20(3-4), 297-312. 0095-0963 https://hdl.handle.net/10356/94086 http://hdl.handle.net/10220/7224 89705 en Automedica © 2001 OPA (Overseas Publishers Association) N.V. 21 p. |
| spellingShingle | DRNTU::Engineering::Mechanical engineering::Bio-mechatronics Shu, Jian Jun Lim, C. W. On DNA modelling : interaction of a double helicoidal structure with viscous bio-fluid |
| title | On DNA modelling : interaction of a double helicoidal structure with viscous bio-fluid |
| title_full | On DNA modelling : interaction of a double helicoidal structure with viscous bio-fluid |
| title_fullStr | On DNA modelling : interaction of a double helicoidal structure with viscous bio-fluid |
| title_full_unstemmed | On DNA modelling : interaction of a double helicoidal structure with viscous bio-fluid |
| title_short | On DNA modelling : interaction of a double helicoidal structure with viscous bio-fluid |
| title_sort | on dna modelling interaction of a double helicoidal structure with viscous bio fluid |
| topic | DRNTU::Engineering::Mechanical engineering::Bio-mechatronics |
| url | https://hdl.handle.net/10356/94086 http://hdl.handle.net/10220/7224 |
| work_keys_str_mv | AT shujianjun ondnamodellinginteractionofadoublehelicoidalstructurewithviscousbiofluid AT limcw ondnamodellinginteractionofadoublehelicoidalstructurewithviscousbiofluid |