Reliable addition of reagents into microfluidic droplets
This article reports a design that reliably adds reagents into droplets by exploiting the physics of fluid flow at a T-junction in the microchannel. An expanded section right after the T-junction enhances merging of a stream with a droplet, eliminates the drawbacks such as extra droplet formation an...
| Main Authors: | , , , , |
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| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
| Published: |
2012
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| Online Access: | https://hdl.handle.net/10356/94113 http://hdl.handle.net/10220/7829 |
| _version_ | 1826119481191038976 |
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| author | Sivasamy Jayaprakash Chim, Yong Cai Wong, Teck Neng Nguyen, Nam-Trung Yobas, Levent |
| author2 | School of Mechanical and Aerospace Engineering |
| author_facet | School of Mechanical and Aerospace Engineering Sivasamy Jayaprakash Chim, Yong Cai Wong, Teck Neng Nguyen, Nam-Trung Yobas, Levent |
| author_sort | Sivasamy Jayaprakash |
| collection | NTU |
| description | This article reports a design that reliably adds reagents into droplets by exploiting the physics of fluid flow at a T-junction in the microchannel. An expanded section right after the T-junction enhances merging of a stream with a droplet, eliminates the drawbacks such as extra droplet formation and long mixing time. The expanded section reduces the pressure buildup at the T-junction and minimizes the tendency to form extra droplets; plays the role in creating low Laplace pressure jump across the interface of the droplet forming from the T-junction which reduces the probability of forming extra droplet in the merging process; provides space for droplet coalescence if there is an extra droplet due to droplet break-up before merging. In this design, after merging, the reactants are in axial arrangement inside the droplets which lead to faster mixing. Reliable addition of reagent to the droplets happens for the combination of flow rates in a broad range from 25 to 250 μl/h, for both DI water (Q DI) and fluorescent (Q fluo) streams. |
| first_indexed | 2024-10-01T05:01:03Z |
| format | Journal Article |
| id | ntu-10356/94113 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T05:01:03Z |
| publishDate | 2012 |
| record_format | dspace |
| spelling | ntu-10356/941132023-03-04T17:18:11Z Reliable addition of reagents into microfluidic droplets Sivasamy Jayaprakash Chim, Yong Cai Wong, Teck Neng Nguyen, Nam-Trung Yobas, Levent School of Mechanical and Aerospace Engineering DRNTU::Engineering::Mechanical engineering This article reports a design that reliably adds reagents into droplets by exploiting the physics of fluid flow at a T-junction in the microchannel. An expanded section right after the T-junction enhances merging of a stream with a droplet, eliminates the drawbacks such as extra droplet formation and long mixing time. The expanded section reduces the pressure buildup at the T-junction and minimizes the tendency to form extra droplets; plays the role in creating low Laplace pressure jump across the interface of the droplet forming from the T-junction which reduces the probability of forming extra droplet in the merging process; provides space for droplet coalescence if there is an extra droplet due to droplet break-up before merging. In this design, after merging, the reactants are in axial arrangement inside the droplets which lead to faster mixing. Reliable addition of reagent to the droplets happens for the combination of flow rates in a broad range from 25 to 250 μl/h, for both DI water (Q DI) and fluorescent (Q fluo) streams. Accepted version 2012-05-10T01:21:29Z 2019-12-06T18:50:53Z 2012-05-10T01:21:29Z 2019-12-06T18:50:53Z 2010 2010 Journal Article Sivasamy, J., Chim, Y. C., Wong,T. N., Nguyen, N. T., & Yobas, L. (2009). Reliable addition of reagents into microfluidic droplets. Microfluidics and Nanofluidics, 8(3), 409-416. https://hdl.handle.net/10356/94113 http://hdl.handle.net/10220/7829 10.1007/s10404-009-0531-5 152452 en Microfluidics and nanofluidics © 2009 Springer-Verlag. This is the author created version of a work that has been peer reviewed and accepted for publication by Microfluidics and Nanofluidics, Springer-Verlag. It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document. The published version is available at: DOI: [http://dx.doi.org/10.1007/s10404-009-0531-5]. 25 p. application/pdf |
| spellingShingle | DRNTU::Engineering::Mechanical engineering Sivasamy Jayaprakash Chim, Yong Cai Wong, Teck Neng Nguyen, Nam-Trung Yobas, Levent Reliable addition of reagents into microfluidic droplets |
| title | Reliable addition of reagents into microfluidic droplets |
| title_full | Reliable addition of reagents into microfluidic droplets |
| title_fullStr | Reliable addition of reagents into microfluidic droplets |
| title_full_unstemmed | Reliable addition of reagents into microfluidic droplets |
| title_short | Reliable addition of reagents into microfluidic droplets |
| title_sort | reliable addition of reagents into microfluidic droplets |
| topic | DRNTU::Engineering::Mechanical engineering |
| url | https://hdl.handle.net/10356/94113 http://hdl.handle.net/10220/7829 |
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