Rapid mixing using two-phase hydraulic focusing in microchannels
Rapid mixing is important in biomedical analysis. In this study, rapid mixing is obtained through two-phase hydraulic focusing in microchannels. Two mixing streams are focused by two sheath streams. Assuming a laminar flow in the channel, the spreading behavior of the two immiscible fluids is modele...
| Những tác giả chính: | , |
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| Tác giả khác: | |
| Định dạng: | Journal Article |
| Ngôn ngữ: | English |
| Được phát hành: |
2012
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| Những chủ đề: | |
| Truy cập trực tuyến: | https://hdl.handle.net/10356/94202 http://hdl.handle.net/10220/7842 |
| _version_ | 1826124737615495168 |
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| author | Wu, Zhigang Nguyen, Nam-Trung |
| author2 | School of Mechanical and Aerospace Engineering |
| author_facet | School of Mechanical and Aerospace Engineering Wu, Zhigang Nguyen, Nam-Trung |
| author_sort | Wu, Zhigang |
| collection | NTU |
| description | Rapid mixing is important in biomedical analysis. In this study, rapid mixing is obtained through two-phase hydraulic focusing in microchannels. Two mixing streams are focused by two sheath streams. Assuming a laminar flow in the channel, the spreading behavior of the two immiscible fluids is modeled and solved analytically. The results show that both viscosity ratio and flow rate ratio between the sheath flow and the sample flow can affect the focusing ratio. Thus, the mixing path of the sample flows can be adjusted by either viscosity ratio or flow rate ratio. Furthermore, an analytical model was proposed and solved for convective/diffusive mixing between the sample streams. According to this model, the focusing ratio is a key parameter for rapid mixing. A fully polymeric micro mixer was fabricated and tested for verification of the presented analytical models. The micromixer was fabricated by laser micromachining and adhesive bonding. The characterization results show the promising potential of mixing in microscale using two-phase hydraulic focusing. |
| first_indexed | 2024-10-01T06:25:35Z |
| format | Journal Article |
| id | ntu-10356/94202 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T06:25:35Z |
| publishDate | 2012 |
| record_format | dspace |
| spelling | ntu-10356/942022023-03-04T17:18:15Z Rapid mixing using two-phase hydraulic focusing in microchannels Wu, Zhigang Nguyen, Nam-Trung School of Mechanical and Aerospace Engineering DRNTU::Engineering::Mechanical engineering Rapid mixing is important in biomedical analysis. In this study, rapid mixing is obtained through two-phase hydraulic focusing in microchannels. Two mixing streams are focused by two sheath streams. Assuming a laminar flow in the channel, the spreading behavior of the two immiscible fluids is modeled and solved analytically. The results show that both viscosity ratio and flow rate ratio between the sheath flow and the sample flow can affect the focusing ratio. Thus, the mixing path of the sample flows can be adjusted by either viscosity ratio or flow rate ratio. Furthermore, an analytical model was proposed and solved for convective/diffusive mixing between the sample streams. According to this model, the focusing ratio is a key parameter for rapid mixing. A fully polymeric micro mixer was fabricated and tested for verification of the presented analytical models. The micromixer was fabricated by laser micromachining and adhesive bonding. The characterization results show the promising potential of mixing in microscale using two-phase hydraulic focusing. Accepted version 2012-05-10T06:23:59Z 2019-12-06T18:52:23Z 2012-05-10T06:23:59Z 2019-12-06T18:52:23Z 2005 2005 Journal Article Wu, Z., & Nguyen, N. T. (2005). Rapid mixing using two-phase hydraulic focusing in microchannels. Biomedical Microdevices, 7(1), 13-20. https://hdl.handle.net/10356/94202 http://hdl.handle.net/10220/7842 10.1007/s10544-005-6167-7 90076 en Biomedical microdevices © 2005 Springer Science+Business Media, Inc. This is the author created version of a work that has been peer reviewed and accepted for publication by Biomedical Microdevices, Springer Science+Business Media, Inc. It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document. The published version is available at: [http://dx.doi.org/10.1007/s10544-005-6167-7]. 15 p. application/pdf |
| spellingShingle | DRNTU::Engineering::Mechanical engineering Wu, Zhigang Nguyen, Nam-Trung Rapid mixing using two-phase hydraulic focusing in microchannels |
| title | Rapid mixing using two-phase hydraulic focusing in microchannels |
| title_full | Rapid mixing using two-phase hydraulic focusing in microchannels |
| title_fullStr | Rapid mixing using two-phase hydraulic focusing in microchannels |
| title_full_unstemmed | Rapid mixing using two-phase hydraulic focusing in microchannels |
| title_short | Rapid mixing using two-phase hydraulic focusing in microchannels |
| title_sort | rapid mixing using two phase hydraulic focusing in microchannels |
| topic | DRNTU::Engineering::Mechanical engineering |
| url | https://hdl.handle.net/10356/94202 http://hdl.handle.net/10220/7842 |
| work_keys_str_mv | AT wuzhigang rapidmixingusingtwophasehydraulicfocusinginmicrochannels AT nguyennamtrung rapidmixingusingtwophasehydraulicfocusinginmicrochannels |