Electrical detection of hybridization and threading intercalation of deoxyribonucleic acid using carbon nanotube network field-effect transistors
The authors study deoxyribonucleic acid (DNA) sensing characteristics of carbon nanotube network...
| Main Authors: | , , , , , , , , , |
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| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
| Published: |
2012
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10356/94252 http://hdl.handle.net/10220/8095 |
| _version_ | 1826118717049667584 |
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| author | Rogers, John A. Gui, Ee Ling Li, Lain-Jong Lee, Pooi See Lohani, Anup Mhaisalkar, Subodh Gautam Cao, Qing Kang, Seong Jun Tansil, Natalia Chendrawati Gao, Zhiqiang |
| author2 | School of Materials Science & Engineering |
| author_facet | School of Materials Science & Engineering Rogers, John A. Gui, Ee Ling Li, Lain-Jong Lee, Pooi See Lohani, Anup Mhaisalkar, Subodh Gautam Cao, Qing Kang, Seong Jun Tansil, Natalia Chendrawati Gao, Zhiqiang |
| author_sort | Rogers, John A. |
| collection | NTU |
| description | The authors study deoxyribonucleic acid (DNA) sensing characteristics of carbon nanotube network
field-effect transistors (CNNFETs) by monitoring their electrical responses upon immobilization
with a DNA probe, hybridization with DNA analytes, and intercalation with a
N,N'-bis(3-propylimidazole)-1,4,5,8-naphthalene diimide modified with Os(2,2'-bipyridine)2Cl+
pendants. The CNNFETs immobilized by single-stranded DNA molecules demonstrate the selective
sensing of its complementary and single-base mismatched DNA (difference of ~16% in reduction
of normalized drain current Id). Subsequent intercalation demonstrates a further sensitivity
enhancement (difference of ~13% in Id reduction due to specific binding between hybridized DNA
and intercalators, corroborated by the x-ray photoelectron spectroscopy study. |
| first_indexed | 2024-10-01T04:48:01Z |
| format | Journal Article |
| id | ntu-10356/94252 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T04:48:01Z |
| publishDate | 2012 |
| record_format | dspace |
| spelling | ntu-10356/942522023-07-14T15:53:40Z Electrical detection of hybridization and threading intercalation of deoxyribonucleic acid using carbon nanotube network field-effect transistors Rogers, John A. Gui, Ee Ling Li, Lain-Jong Lee, Pooi See Lohani, Anup Mhaisalkar, Subodh Gautam Cao, Qing Kang, Seong Jun Tansil, Natalia Chendrawati Gao, Zhiqiang School of Materials Science & Engineering DRNTU::Engineering::Materials::Nanostructured materials The authors study deoxyribonucleic acid (DNA) sensing characteristics of carbon nanotube network field-effect transistors (CNNFETs) by monitoring their electrical responses upon immobilization with a DNA probe, hybridization with DNA analytes, and intercalation with a N,N'-bis(3-propylimidazole)-1,4,5,8-naphthalene diimide modified with Os(2,2'-bipyridine)2Cl+ pendants. The CNNFETs immobilized by single-stranded DNA molecules demonstrate the selective sensing of its complementary and single-base mismatched DNA (difference of ~16% in reduction of normalized drain current Id). Subsequent intercalation demonstrates a further sensitivity enhancement (difference of ~13% in Id reduction due to specific binding between hybridized DNA and intercalators, corroborated by the x-ray photoelectron spectroscopy study. Published version 2012-05-18T07:08:45Z 2019-12-06T18:53:16Z 2012-05-18T07:08:45Z 2019-12-06T18:53:16Z 2006 2006 Journal Article Gui, E. L., Li, L. J., Lee, P. S., Lohani, A., Mhaisalkar, S. G., Cao, Q., et al. (2006). Electrical detection of hybridization and threading intercalation of deoxyribonucleic acid using carbon nanotube network field effect transistors. Applied physics letters, 89(23). https://hdl.handle.net/10356/94252 http://hdl.handle.net/10220/8095 10.1063/1.2399355 en Applied physics letters © 2006 American Institute of Physics. This paper was published in Applied Physics Letters and is made available as an electronic reprint (preprint) with permission of American Institute of Physics. The paper can be found at the following official URL: http://dx.doi.org/10.1063/1.2399355. One print or electronic copy may be made for personal use only. Systematic or multiple reproduction, distribution to multiple locations via electronic or other means, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper is prohibited and is subject to penalties under law. 3 p. application/pdf |
| spellingShingle | DRNTU::Engineering::Materials::Nanostructured materials Rogers, John A. Gui, Ee Ling Li, Lain-Jong Lee, Pooi See Lohani, Anup Mhaisalkar, Subodh Gautam Cao, Qing Kang, Seong Jun Tansil, Natalia Chendrawati Gao, Zhiqiang Electrical detection of hybridization and threading intercalation of deoxyribonucleic acid using carbon nanotube network field-effect transistors |
| title | Electrical detection of hybridization and threading intercalation of deoxyribonucleic acid using carbon nanotube network field-effect transistors |
| title_full | Electrical detection of hybridization and threading intercalation of deoxyribonucleic acid using carbon nanotube network field-effect transistors |
| title_fullStr | Electrical detection of hybridization and threading intercalation of deoxyribonucleic acid using carbon nanotube network field-effect transistors |
| title_full_unstemmed | Electrical detection of hybridization and threading intercalation of deoxyribonucleic acid using carbon nanotube network field-effect transistors |
| title_short | Electrical detection of hybridization and threading intercalation of deoxyribonucleic acid using carbon nanotube network field-effect transistors |
| title_sort | electrical detection of hybridization and threading intercalation of deoxyribonucleic acid using carbon nanotube network field effect transistors |
| topic | DRNTU::Engineering::Materials::Nanostructured materials |
| url | https://hdl.handle.net/10356/94252 http://hdl.handle.net/10220/8095 |
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