Quantitative model for the interecho time dependence of the CPMG relaxation rate in iron-rich gray matter
A quantitative model is proposed for computing the dependence on the interecho time of the NMR relaxation rate in iron-rich gray matter obtained with a Carr-Purcell-Meiboom-Gill sequence. The model consists of representing oligodendrocytes as identical magnetic spheres arranged in a spatially random...
| Main Authors: | , , |
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| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
| Published: |
2012
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| Online Access: | https://hdl.handle.net/10356/94287 http://hdl.handle.net/10220/8747 |
| _version_ | 1811692998313902080 |
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| author | Jensen, J. H. Chandra, R. Yu, Hao |
| author2 | School of Electrical and Electronic Engineering |
| author_facet | School of Electrical and Electronic Engineering Jensen, J. H. Chandra, R. Yu, Hao |
| author_sort | Jensen, J. H. |
| collection | NTU |
| description | A quantitative model is proposed for computing the dependence on the interecho time of the NMR relaxation rate in iron-rich gray matter obtained with a Carr-Purcell-Meiboom-Gill sequence. The model consists of representing oligodendrocytes as identical magnetic spheres arranged in a spatially random pattern, and in approximating water diffusion as isotropic and unrestricted. Predictions of the model are calculated numerically using a Monte Carlo technique and, for the weak field limit, using an analytic formula. The model is shown to provide a good fit to experimental measurements of in vitro samples of monkey brain at field levels of 1.0 T and 1.5 T. These field levels are not sufficient to fully determine the model parameters, but it is argued that this may be possible at 3.0 T. The model is potentially of value for multiple-spin-echo MRI studies of iron-related neurodegenerative disorders, such as Parkinson's disease. In particular, the model can be applied to correlate MRI data with the cellular distribution of iron in gray matter. |
| first_indexed | 2024-10-01T06:44:41Z |
| format | Journal Article |
| id | ntu-10356/94287 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T06:44:41Z |
| publishDate | 2012 |
| record_format | dspace |
| spelling | ntu-10356/942872020-03-07T14:02:44Z Quantitative model for the interecho time dependence of the CPMG relaxation rate in iron-rich gray matter Jensen, J. H. Chandra, R. Yu, Hao School of Electrical and Electronic Engineering DRNTU::Engineering::Electrical and electronic engineering A quantitative model is proposed for computing the dependence on the interecho time of the NMR relaxation rate in iron-rich gray matter obtained with a Carr-Purcell-Meiboom-Gill sequence. The model consists of representing oligodendrocytes as identical magnetic spheres arranged in a spatially random pattern, and in approximating water diffusion as isotropic and unrestricted. Predictions of the model are calculated numerically using a Monte Carlo technique and, for the weak field limit, using an analytic formula. The model is shown to provide a good fit to experimental measurements of in vitro samples of monkey brain at field levels of 1.0 T and 1.5 T. These field levels are not sufficient to fully determine the model parameters, but it is argued that this may be possible at 3.0 T. The model is potentially of value for multiple-spin-echo MRI studies of iron-related neurodegenerative disorders, such as Parkinson's disease. In particular, the model can be applied to correlate MRI data with the cellular distribution of iron in gray matter. 2012-10-10T08:23:34Z 2019-12-06T18:53:42Z 2012-10-10T08:23:34Z 2019-12-06T18:53:42Z 2001 2001 Journal Article Jensen, J. H., Chandra, R., & Yu, H. (2001). Quantitative model for the interecho time dependence of the CPMG relaxation rate in iron-rich gray matter. Magnetic Resonance in Medicine, 46(1), 159-165. https://hdl.handle.net/10356/94287 http://hdl.handle.net/10220/8747 10.1002/mrm.1171 148337 en Magnetic resonance in medicine © 2001 Wiley-Liss, Inc. |
| spellingShingle | DRNTU::Engineering::Electrical and electronic engineering Jensen, J. H. Chandra, R. Yu, Hao Quantitative model for the interecho time dependence of the CPMG relaxation rate in iron-rich gray matter |
| title | Quantitative model for the interecho time dependence of the CPMG relaxation rate in iron-rich gray matter |
| title_full | Quantitative model for the interecho time dependence of the CPMG relaxation rate in iron-rich gray matter |
| title_fullStr | Quantitative model for the interecho time dependence of the CPMG relaxation rate in iron-rich gray matter |
| title_full_unstemmed | Quantitative model for the interecho time dependence of the CPMG relaxation rate in iron-rich gray matter |
| title_short | Quantitative model for the interecho time dependence of the CPMG relaxation rate in iron-rich gray matter |
| title_sort | quantitative model for the interecho time dependence of the cpmg relaxation rate in iron rich gray matter |
| topic | DRNTU::Engineering::Electrical and electronic engineering |
| url | https://hdl.handle.net/10356/94287 http://hdl.handle.net/10220/8747 |
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