The crosstalks between adipokines and catecholamines
Adipocytes, which secrete a spectrum of adipokines, play an integral role in metabolism via communications with other endocrine cells. In the present work, we have studied the interplays between adipokines and catecholamines, using 3T3-L1 adipocytes and PC12 cells as the cell models and an integrati...
| Main Authors: | , , , , , |
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| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
| Published: |
2012
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| Online Access: | https://hdl.handle.net/10356/94429 http://hdl.handle.net/10220/7521 |
| _version_ | 1826117169530798080 |
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| author | Than, Aung Ye, Feng Xue, Renhao Ong, Jun Wei Poh, Chueh Loo Chen, Peng |
| author2 | School of Chemical and Biomedical Engineering |
| author_facet | School of Chemical and Biomedical Engineering Than, Aung Ye, Feng Xue, Renhao Ong, Jun Wei Poh, Chueh Loo Chen, Peng |
| author_sort | Than, Aung |
| collection | NTU |
| description | Adipocytes, which secrete a spectrum of adipokines, play an integral role in metabolism via communications with other endocrine cells. In the present work, we have studied the interplays between adipokines and catecholamines, using 3T3-L1 adipocytes and PC12 cells as the cell models and an integrative experimental platform. We demonstrate that all catecholamines inhibit vesicle trafficking and secretion of leptin and resistin through β-adrenergic receptors, while leptin and resistin enhance the vesicle trafficking and secretion of catecholamines through PKC, PKA, MAPK kinase and Ca2+ dependent pathways. The crosstalks between adipokines and catecholamines were further corroborated by co-culturing 3T3-L1 adipocytes and PC12 cells. Our findings highlight the importance of adipo-adrenal axis in energy metabolism and the intricate interactions between metabolic hormones. |
| first_indexed | 2024-10-01T04:23:16Z |
| format | Journal Article |
| id | ntu-10356/94429 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T04:23:16Z |
| publishDate | 2012 |
| record_format | dspace |
| spelling | ntu-10356/944292023-12-29T06:47:42Z The crosstalks between adipokines and catecholamines Than, Aung Ye, Feng Xue, Renhao Ong, Jun Wei Poh, Chueh Loo Chen, Peng School of Chemical and Biomedical Engineering DRNTU::Science::Medicine::Biomedical engineering Adipocytes, which secrete a spectrum of adipokines, play an integral role in metabolism via communications with other endocrine cells. In the present work, we have studied the interplays between adipokines and catecholamines, using 3T3-L1 adipocytes and PC12 cells as the cell models and an integrative experimental platform. We demonstrate that all catecholamines inhibit vesicle trafficking and secretion of leptin and resistin through β-adrenergic receptors, while leptin and resistin enhance the vesicle trafficking and secretion of catecholamines through PKC, PKA, MAPK kinase and Ca2+ dependent pathways. The crosstalks between adipokines and catecholamines were further corroborated by co-culturing 3T3-L1 adipocytes and PC12 cells. Our findings highlight the importance of adipo-adrenal axis in energy metabolism and the intricate interactions between metabolic hormones. Accepted version 2012-02-14T06:31:26Z 2019-12-06T18:55:51Z 2012-02-14T06:31:26Z 2019-12-06T18:55:51Z 2010 2010 Journal Article Than, A., Ye, F., Xue, R., Ong, J. W., Poh, C. L. & Chen P. (2011). The Crosstalks Between Adipokines and Catecholamines. Molecular and Cellular Endocrinology, 332(1-2), 261-270. https://hdl.handle.net/10356/94429 http://hdl.handle.net/10220/7521 10.1016/j.mce.2010.11.002 163183 en Molecular and cellular endocrinology © 2010 Elsevier Ireland Ltd. This is the author created version of a work that has been peer reviewed and accepted for publication by Molecular and Cellular Endocrinology, Elsevier Ireland Ltd. It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document. The published version is available at: [DOI: http://dx.doi.org/10.1016/j.mce.2010.11.002] application/pdf |
| spellingShingle | DRNTU::Science::Medicine::Biomedical engineering Than, Aung Ye, Feng Xue, Renhao Ong, Jun Wei Poh, Chueh Loo Chen, Peng The crosstalks between adipokines and catecholamines |
| title | The crosstalks between adipokines and catecholamines |
| title_full | The crosstalks between adipokines and catecholamines |
| title_fullStr | The crosstalks between adipokines and catecholamines |
| title_full_unstemmed | The crosstalks between adipokines and catecholamines |
| title_short | The crosstalks between adipokines and catecholamines |
| title_sort | crosstalks between adipokines and catecholamines |
| topic | DRNTU::Science::Medicine::Biomedical engineering |
| url | https://hdl.handle.net/10356/94429 http://hdl.handle.net/10220/7521 |
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