Effects of LNA modification on the stability and structure of DNA G-quadruplex
Formation of G-quadruplex by DNA can inhibit activity of telomerase, hence stop proliferation of cancer cells[1-2]. Thus, quadruplex-forming oligonucleotides have promising anticancer pharmaceutical potential. Because of LNA’s (Locked Nucleic Acid) biostability[3], the lifetime of LNA modified oligo...
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| Format: | Student Research Poster |
| Language: | English |
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2013
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| Online Access: | https://hdl.handle.net/10356/94624 http://hdl.handle.net/10220/9099 |
| _version_ | 1811688025228312576 |
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| author | Li, Zhe |
| author2 | Phan Anh Tuan |
| author_facet | Phan Anh Tuan Li, Zhe |
| author_sort | Li, Zhe |
| collection | NTU |
| description | Formation of G-quadruplex by DNA can inhibit activity of telomerase, hence stop proliferation of cancer cells[1-2]. Thus, quadruplex-forming oligonucleotides have promising anticancer pharmaceutical potential. Because of LNA’s (Locked Nucleic Acid) biostability[3], the lifetime of LNA modified oligonucleotide can be prolonged. Knowledge of the LNA modified G-quadruplex’s stability and structure[4-5] can help in drug design. This project uses various biophysical techniques including 1D and 2D NMR (Nuclear Magnetic Resonance), CD (Circular Dichroism) and UV (UltraViolet) absorption spectroscopy to investigate the effect of LNA modifications on a quadruplex-forming human telomeric sequence. [2nd Award] |
| first_indexed | 2024-10-01T05:25:38Z |
| format | Student Research Poster |
| id | ntu-10356/94624 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T05:25:38Z |
| publishDate | 2013 |
| record_format | dspace |
| spelling | ntu-10356/946242020-09-27T20:29:07Z Effects of LNA modification on the stability and structure of DNA G-quadruplex Li, Zhe Phan Anh Tuan School of Physical and Mathematical Sciences DNA G-quadruplex Formation of G-quadruplex by DNA can inhibit activity of telomerase, hence stop proliferation of cancer cells[1-2]. Thus, quadruplex-forming oligonucleotides have promising anticancer pharmaceutical potential. Because of LNA’s (Locked Nucleic Acid) biostability[3], the lifetime of LNA modified oligonucleotide can be prolonged. Knowledge of the LNA modified G-quadruplex’s stability and structure[4-5] can help in drug design. This project uses various biophysical techniques including 1D and 2D NMR (Nuclear Magnetic Resonance), CD (Circular Dichroism) and UV (UltraViolet) absorption spectroscopy to investigate the effect of LNA modifications on a quadruplex-forming human telomeric sequence. [2nd Award] 2013-02-04T02:47:58Z 2019-12-06T18:59:21Z 2013-02-04T02:47:58Z 2019-12-06T18:59:21Z 2011 2011 Student Research Poster Li, Z. (2011, March). Effects of LNA modification on the stability and structure of DNA G-quadruplex. Presented at Discover URECA @ NTU poster exhibition and competition, Nanyang Technological University, Singapore. https://hdl.handle.net/10356/94624 http://hdl.handle.net/10220/9099 en © 2011 The Author(s). application/pdf |
| spellingShingle | DNA G-quadruplex Li, Zhe Effects of LNA modification on the stability and structure of DNA G-quadruplex |
| title | Effects of LNA modification on the stability and structure of DNA G-quadruplex |
| title_full | Effects of LNA modification on the stability and structure of DNA G-quadruplex |
| title_fullStr | Effects of LNA modification on the stability and structure of DNA G-quadruplex |
| title_full_unstemmed | Effects of LNA modification on the stability and structure of DNA G-quadruplex |
| title_short | Effects of LNA modification on the stability and structure of DNA G-quadruplex |
| title_sort | effects of lna modification on the stability and structure of dna g quadruplex |
| topic | DNA G-quadruplex |
| url | https://hdl.handle.net/10356/94624 http://hdl.handle.net/10220/9099 |
| work_keys_str_mv | AT lizhe effectsoflnamodificationonthestabilityandstructureofdnagquadruplex |