Effects of LNA modification on the stability and structure of DNA G-quadruplex
Formation of G-quadruplex by DNA can inhibit activity of telomerase, hence stop proliferation of cancer cells[1-2]. Thus, quadruplex-forming oligonucleotides have promising anticancer pharmaceutical potential. Because of LNA’s (Locked Nucleic Acid) biostability[3], the lifetime of LNA modified oligo...
| 主要作者: | |
|---|---|
| 其他作者: | |
| 格式: | Student Research Poster |
| 語言: | English |
| 出版: |
2013
|
| 主題: | |
| 在線閱讀: | https://hdl.handle.net/10356/94624 http://hdl.handle.net/10220/9099 |