Angiopoietin-like 4 protein elevates the prosurvival intracellular O2(-) : H2O2 ratio and confers anoikis resistance to tumors
Cancer is a leading cause of death worldwide. Tumor cells exploit various signaling pathways to promote their growth and metastasis. To our knowledge, the role of angiopoietin-like 4 protein (ANGPTL4) in cancer remains undefined. Here, we found that elevated ANGPTL4 expression is widespread in tumor...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Journal Article |
| Language: | English |
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2012
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| Online Access: | https://hdl.handle.net/10356/94754 http://hdl.handle.net/10220/8177 |
| _version_ | 1826121080766464000 |
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| author | Zhu, Pengcheng Tan, Ming Jie Huang, Royston-Luke Tan, Chek Kun Chong, Han Chung Pal, Mintu Lam, Ivan Chee Ren Boukamp, Petra Pan, Jiun Yit Tan, Suat Hoon Kersten, Sander Li, Hoi-Yeung Ding, Jeak Ling Tan, Nguan Soon |
| author2 | School of Biological Sciences |
| author_facet | School of Biological Sciences Zhu, Pengcheng Tan, Ming Jie Huang, Royston-Luke Tan, Chek Kun Chong, Han Chung Pal, Mintu Lam, Ivan Chee Ren Boukamp, Petra Pan, Jiun Yit Tan, Suat Hoon Kersten, Sander Li, Hoi-Yeung Ding, Jeak Ling Tan, Nguan Soon |
| author_sort | Zhu, Pengcheng |
| collection | NTU |
| description | Cancer is a leading cause of death worldwide. Tumor cells exploit various signaling pathways to promote their growth and metastasis. To our knowledge, the role of angiopoietin-like 4 protein (ANGPTL4) in cancer remains undefined. Here, we found that elevated ANGPTL4 expression is widespread in tumors, and its suppression impairs tumor growth associated with enhanced apoptosis. Tumor-derived ANGPTL4 interacts with integrins to stimulate NADPH oxidase-dependent production of O2(-). A high ratio of O2:(-)H2O2 oxidizes/activates Src, triggering the PI3K/PKBα and ERK prosurvival pathways to confer anoikis resistance, thus promoting tumor growth. ANGPTL4 deficiency results in diminished O2(-) production and a reduced O2:(-)H2O2 ratio, creating a cellular environment conducive to apoptosis. ANGPTL4 is an important redox player in cancer and a potential therapeutic target. |
| first_indexed | 2024-10-01T05:26:54Z |
| format | Journal Article |
| id | ntu-10356/94754 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T05:26:54Z |
| publishDate | 2012 |
| record_format | dspace |
| spelling | ntu-10356/947542023-02-28T17:03:05Z Angiopoietin-like 4 protein elevates the prosurvival intracellular O2(-) : H2O2 ratio and confers anoikis resistance to tumors Zhu, Pengcheng Tan, Ming Jie Huang, Royston-Luke Tan, Chek Kun Chong, Han Chung Pal, Mintu Lam, Ivan Chee Ren Boukamp, Petra Pan, Jiun Yit Tan, Suat Hoon Kersten, Sander Li, Hoi-Yeung Ding, Jeak Ling Tan, Nguan Soon School of Biological Sciences DRNTU::Science::Biological sciences::Cytology Cancer is a leading cause of death worldwide. Tumor cells exploit various signaling pathways to promote their growth and metastasis. To our knowledge, the role of angiopoietin-like 4 protein (ANGPTL4) in cancer remains undefined. Here, we found that elevated ANGPTL4 expression is widespread in tumors, and its suppression impairs tumor growth associated with enhanced apoptosis. Tumor-derived ANGPTL4 interacts with integrins to stimulate NADPH oxidase-dependent production of O2(-). A high ratio of O2:(-)H2O2 oxidizes/activates Src, triggering the PI3K/PKBα and ERK prosurvival pathways to confer anoikis resistance, thus promoting tumor growth. ANGPTL4 deficiency results in diminished O2(-) production and a reduced O2:(-)H2O2 ratio, creating a cellular environment conducive to apoptosis. ANGPTL4 is an important redox player in cancer and a potential therapeutic target. 2012-05-29T08:21:55Z 2019-12-06T19:01:33Z 2012-05-29T08:21:55Z 2019-12-06T19:01:33Z 2011 2011 Journal Article Zhu, P., Tan, M. J., Huang, R. L., Tan, C. K., Chong, H. C., Pal, M., et al. (2011). Angiopoietin-like 4 Protein Elevates the Prosurvival Intracellular O2(-): H2O2 Ratio and Confers Anoikis Resistance to Tumors. Cancer cell, 19(3), 401-415. https://hdl.handle.net/10356/94754 http://hdl.handle.net/10220/8177 10.1016/j.ccr.2011.01.018 164662 en Cancer cell © 2011 Elsevier Inc. This is the author created version of a work that has been peer reviewed and accepted for publication by Cancer Cell, Elsevier. It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document. The published version is available at: [DOI: http://dx.doi.org/10.1016/j.ccr.2011.01.018 ] 15 p. application/pdf |
| spellingShingle | DRNTU::Science::Biological sciences::Cytology Zhu, Pengcheng Tan, Ming Jie Huang, Royston-Luke Tan, Chek Kun Chong, Han Chung Pal, Mintu Lam, Ivan Chee Ren Boukamp, Petra Pan, Jiun Yit Tan, Suat Hoon Kersten, Sander Li, Hoi-Yeung Ding, Jeak Ling Tan, Nguan Soon Angiopoietin-like 4 protein elevates the prosurvival intracellular O2(-) : H2O2 ratio and confers anoikis resistance to tumors |
| title | Angiopoietin-like 4 protein elevates the prosurvival intracellular O2(-) : H2O2 ratio and confers anoikis resistance to tumors |
| title_full | Angiopoietin-like 4 protein elevates the prosurvival intracellular O2(-) : H2O2 ratio and confers anoikis resistance to tumors |
| title_fullStr | Angiopoietin-like 4 protein elevates the prosurvival intracellular O2(-) : H2O2 ratio and confers anoikis resistance to tumors |
| title_full_unstemmed | Angiopoietin-like 4 protein elevates the prosurvival intracellular O2(-) : H2O2 ratio and confers anoikis resistance to tumors |
| title_short | Angiopoietin-like 4 protein elevates the prosurvival intracellular O2(-) : H2O2 ratio and confers anoikis resistance to tumors |
| title_sort | angiopoietin like 4 protein elevates the prosurvival intracellular o2 h2o2 ratio and confers anoikis resistance to tumors |
| topic | DRNTU::Science::Biological sciences::Cytology |
| url | https://hdl.handle.net/10356/94754 http://hdl.handle.net/10220/8177 |
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