SMAD3 deficiency promotes inflammatory aortic aneurysms in angiotensin II–infused mice via activation of iNOS

SMAD3 deficiency promotes inflammatory aortic aneurysms in angiotensin II–infused mice via activation of iNOS

Ninety percent of the patients carrying distinct SMAD3 mutations develop aortic aneurysms and dissections, called aneurysms-osteoarthritis syndrome (AOS). However, the etiology and molecular events downstream of SMAD3 leading to the pathogenesis of aortic aneurysms in these patients still remain elu...

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Bibliographic Details
Main Authors: Tan, Eddie H., Tan, Chek Kun, Luo, Baiwen, Huang, Charlotte Liwen, Loo, Say Chye Joachim, Choong, Cleo Swee Neo, Tan, Nguan Soon
Other Authors: School of Materials Science & Engineering
Format: Journal Article
Language:English
Published: 2013
Subjects:
DRNTU::Science::Biological sciences
Online Access:https://hdl.handle.net/10356/95753
http://hdl.handle.net/10220/10649

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