Anti-platelet and tissue engineering approaches to biomaterial blood compatibilization : how well have these been translated into the clinic?
In this article, we provide an update on the various approaches to “blood compatibilization”, and include both passive and active approaches to compatibilizing biomaterials in contact with blood. Broadly speaking, the surface modification approaches involved either repel platelets or attract endothe...
| Main Authors: | , , |
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| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
| Published: |
2013
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| Online Access: | https://hdl.handle.net/10356/95863 http://hdl.handle.net/10220/10863 |
| _version_ | 1811696559831646208 |
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| author | Irvine, Scott Alexander. Yun, Xia. Venkatraman, Subbu S. |
| author2 | School of Materials Science & Engineering |
| author_facet | School of Materials Science & Engineering Irvine, Scott Alexander. Yun, Xia. Venkatraman, Subbu S. |
| author_sort | Irvine, Scott Alexander. |
| collection | NTU |
| description | In this article, we provide an update on the various approaches to “blood compatibilization”, and include both passive and active approaches to compatibilizing biomaterials in contact with blood. Broadly speaking, the surface modification approaches involved either repel platelets or attract endothelial cells. For platelet-repelling surfaces, heparin immobilization seems to be the most successful approach. At least two such surfaces have been approved by the health authorities in various countries for applications involving short-term contact with blood. For active endothelialization, ex vivo seeding with autologous cells has been translated into the clinic, while selective endothelial cell capture is a promising approach. In spite of over 30 years of research in this area, a truly intrinsically non-clotting surface has not been developed yet; certain promising avenues have been indicated by the research, which we will critically assess here. |
| first_indexed | 2024-10-01T07:41:18Z |
| format | Journal Article |
| id | ntu-10356/95863 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T07:41:18Z |
| publishDate | 2013 |
| record_format | dspace |
| spelling | ntu-10356/958632020-06-01T10:01:33Z Anti-platelet and tissue engineering approaches to biomaterial blood compatibilization : how well have these been translated into the clinic? Irvine, Scott Alexander. Yun, Xia. Venkatraman, Subbu S. School of Materials Science & Engineering In this article, we provide an update on the various approaches to “blood compatibilization”, and include both passive and active approaches to compatibilizing biomaterials in contact with blood. Broadly speaking, the surface modification approaches involved either repel platelets or attract endothelial cells. For platelet-repelling surfaces, heparin immobilization seems to be the most successful approach. At least two such surfaces have been approved by the health authorities in various countries for applications involving short-term contact with blood. For active endothelialization, ex vivo seeding with autologous cells has been translated into the clinic, while selective endothelial cell capture is a promising approach. In spite of over 30 years of research in this area, a truly intrinsically non-clotting surface has not been developed yet; certain promising avenues have been indicated by the research, which we will critically assess here. 2013-07-01T06:51:45Z 2019-12-06T19:22:26Z 2013-07-01T06:51:45Z 2019-12-06T19:22:26Z 2012 2012 Journal Article Irvine, S. A., Yun, X., & Venkatraman, S. (2012). Anti-platelet and tissue engineering approaches to biomaterial blood compatibilization: how well have these been translated into the clinic?. Drug Delivery and Translational Research, 2(5), 384-397. 2190-393X https://hdl.handle.net/10356/95863 http://hdl.handle.net/10220/10863 10.1007/s13346-012-0077-z en Drug delivery and translational research © 2012 Controlled Release Society. |
| spellingShingle | Irvine, Scott Alexander. Yun, Xia. Venkatraman, Subbu S. Anti-platelet and tissue engineering approaches to biomaterial blood compatibilization : how well have these been translated into the clinic? |
| title | Anti-platelet and tissue engineering approaches to biomaterial blood compatibilization : how well have these been translated into the clinic? |
| title_full | Anti-platelet and tissue engineering approaches to biomaterial blood compatibilization : how well have these been translated into the clinic? |
| title_fullStr | Anti-platelet and tissue engineering approaches to biomaterial blood compatibilization : how well have these been translated into the clinic? |
| title_full_unstemmed | Anti-platelet and tissue engineering approaches to biomaterial blood compatibilization : how well have these been translated into the clinic? |
| title_short | Anti-platelet and tissue engineering approaches to biomaterial blood compatibilization : how well have these been translated into the clinic? |
| title_sort | anti platelet and tissue engineering approaches to biomaterial blood compatibilization how well have these been translated into the clinic |
| url | https://hdl.handle.net/10356/95863 http://hdl.handle.net/10220/10863 |
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