Brain pacemaker to lift anxiety-like behaviour after acute and long-term stimulation of rats
Deep brain stimulation (DBS) is currently being investigated as a potential therapy for treatment-resistant depression. To date, a promising target for DBS as therapy is the subcallosal cingulate gyrus or medial prefrontal cortex (mPFC), with approximately 60% of patients being characterized as resp...
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| Other Authors: | |
| Format: | Student Research Poster |
| Language: | English |
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2013
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| Online Access: | https://hdl.handle.net/10356/95901 http://hdl.handle.net/10220/11308 |
| _version_ | 1826124816146497536 |
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| author | Muhammad, Sharafuddin B. M. K. |
| author2 | Ajai Vyas |
| author_facet | Ajai Vyas Muhammad, Sharafuddin B. M. K. |
| author_sort | Muhammad, Sharafuddin B. M. K. |
| collection | NTU |
| description | Deep brain stimulation (DBS) is currently being investigated as a potential therapy for treatment-resistant depression. To date, a promising target for DBS as therapy is the subcallosal cingulate gyrus or medial prefrontal cortex (mPFC), with approximately 60% of patients being characterized as responders. Despite the encouraging findings, the long-term stimulation (LTS) effects on anxiety-like behaviour have not been extensively investigated. In the present study, we report on the effects of acute and long-term bilateral mPFC DBS tested across different paradigms of anxiety-like behaviours. We hypothesized that LTS would exert its therapeutic effects by altering the dysfunctional neural activity leading to normal functional brain circuits. [3rd Award] |
| first_indexed | 2024-10-01T06:26:32Z |
| format | Student Research Poster |
| id | ntu-10356/95901 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T06:26:32Z |
| publishDate | 2013 |
| record_format | dspace |
| spelling | ntu-10356/959012020-09-27T20:29:36Z Brain pacemaker to lift anxiety-like behaviour after acute and long-term stimulation of rats Muhammad, Sharafuddin B. M. K. Ajai Vyas School of Biological Sciences Deep brain stimulation Acute stimulation Deep brain stimulation (DBS) is currently being investigated as a potential therapy for treatment-resistant depression. To date, a promising target for DBS as therapy is the subcallosal cingulate gyrus or medial prefrontal cortex (mPFC), with approximately 60% of patients being characterized as responders. Despite the encouraging findings, the long-term stimulation (LTS) effects on anxiety-like behaviour have not been extensively investigated. In the present study, we report on the effects of acute and long-term bilateral mPFC DBS tested across different paradigms of anxiety-like behaviours. We hypothesized that LTS would exert its therapeutic effects by altering the dysfunctional neural activity leading to normal functional brain circuits. [3rd Award] 2013-07-12T04:21:44Z 2019-12-06T19:23:09Z 2013-07-12T04:21:44Z 2019-12-06T19:23:09Z 2013 2013 Student Research Poster Muhammad, S. B. M. K. (2013, March). Brain Pacemaker to lift Anxiety-Like Behaviour after Acute and Long-Term Stimulation of Rats. Presented at Discover URECA @ NTU poster exhibition and competition, Nanyang Technological University, Singapore. https://hdl.handle.net/10356/95901 http://hdl.handle.net/10220/11308 en © 2013 The Author(s). application/pdf |
| spellingShingle | Deep brain stimulation Acute stimulation Muhammad, Sharafuddin B. M. K. Brain pacemaker to lift anxiety-like behaviour after acute and long-term stimulation of rats |
| title | Brain pacemaker to lift anxiety-like behaviour after acute and long-term stimulation of rats |
| title_full | Brain pacemaker to lift anxiety-like behaviour after acute and long-term stimulation of rats |
| title_fullStr | Brain pacemaker to lift anxiety-like behaviour after acute and long-term stimulation of rats |
| title_full_unstemmed | Brain pacemaker to lift anxiety-like behaviour after acute and long-term stimulation of rats |
| title_short | Brain pacemaker to lift anxiety-like behaviour after acute and long-term stimulation of rats |
| title_sort | brain pacemaker to lift anxiety like behaviour after acute and long term stimulation of rats |
| topic | Deep brain stimulation Acute stimulation |
| url | https://hdl.handle.net/10356/95901 http://hdl.handle.net/10220/11308 |
| work_keys_str_mv | AT muhammadsharafuddinbmk brainpacemakertoliftanxietylikebehaviourafteracuteandlongtermstimulationofrats |