Generation of ultralarge Surface Enhanced Raman Spectroscopy (SERS)-active hot-spot volumes by an array of 2D nano-superlenses
Surface Enhanced Raman Spectroscopy (or SERS) has received tremendous attention in the past three decades. However, the extremely-confined probe volume (1 nm) of the plasmonic hot-spots occurring on a conventional roughened SERS-active metallic surface has limited value in macro-molecular studies. I...
| Main Authors: | , , |
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| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
| Published: |
2013
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| Online Access: | https://hdl.handle.net/10356/95978 http://hdl.handle.net/10220/10757 |
| _version_ | 1826124581918736384 |
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| author | Wei, Kho Kiang Shen, Zexiang Malini, Olivo |
| author2 | School of Physical and Mathematical Sciences |
| author_facet | School of Physical and Mathematical Sciences Wei, Kho Kiang Shen, Zexiang Malini, Olivo |
| author_sort | Wei, Kho Kiang |
| collection | NTU |
| description | Surface Enhanced Raman Spectroscopy (or SERS) has received tremendous attention in the past three decades. However, the extremely-confined probe volume (1 nm) of the plasmonic hot-spots occurring on a conventional roughened SERS-active metallic surface has limited value in macro-molecular studies. In this article, we show the plausibility of generating large SERS hot-spot volumes on an atomically-flat metal surface based upon a special 3D adiabatic plasmonic nano-focusing effect brought about by an array of nano-scale superlenses. We experimentally demonstrate the feasibility of this particular approach and report, for the first time, the acquisition of whole-protein SERS spectra of a layer of test protein, Cytochrome-c, using a custom-made Otto-Raman spectroscopy system equipped with nano-fluidics. Our study shows the potential of whole-protein SERS spectroscopy as a useful analytical tool that complements surface probe microscopies. |
| first_indexed | 2024-10-01T06:23:04Z |
| format | Journal Article |
| id | ntu-10356/95978 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T06:23:04Z |
| publishDate | 2013 |
| record_format | dspace |
| spelling | ntu-10356/959782020-03-07T12:37:22Z Generation of ultralarge Surface Enhanced Raman Spectroscopy (SERS)-active hot-spot volumes by an array of 2D nano-superlenses Wei, Kho Kiang Shen, Zexiang Malini, Olivo School of Physical and Mathematical Sciences Surface Enhanced Raman Spectroscopy (or SERS) has received tremendous attention in the past three decades. However, the extremely-confined probe volume (1 nm) of the plasmonic hot-spots occurring on a conventional roughened SERS-active metallic surface has limited value in macro-molecular studies. In this article, we show the plausibility of generating large SERS hot-spot volumes on an atomically-flat metal surface based upon a special 3D adiabatic plasmonic nano-focusing effect brought about by an array of nano-scale superlenses. We experimentally demonstrate the feasibility of this particular approach and report, for the first time, the acquisition of whole-protein SERS spectra of a layer of test protein, Cytochrome-c, using a custom-made Otto-Raman spectroscopy system equipped with nano-fluidics. Our study shows the potential of whole-protein SERS spectroscopy as a useful analytical tool that complements surface probe microscopies. 2013-06-27T02:08:06Z 2019-12-06T19:23:58Z 2013-06-27T02:08:06Z 2019-12-06T19:23:58Z 2011 2011 Journal Article Wei, K. K., Shen, Z., & Malini, O. (2012). Generation of ultralarge Surface Enhanced Raman Spectroscopy (SERS)-active hot-spot volumes by an array of 2D nano-superlenses. Analytical chemistry, 84(2), 908-916. 0003-2700 https://hdl.handle.net/10356/95978 http://hdl.handle.net/10220/10757 10.1021/ac201712k en Analytical chemistry © 2011 American Chemical Society. |
| spellingShingle | Wei, Kho Kiang Shen, Zexiang Malini, Olivo Generation of ultralarge Surface Enhanced Raman Spectroscopy (SERS)-active hot-spot volumes by an array of 2D nano-superlenses |
| title | Generation of ultralarge Surface Enhanced Raman Spectroscopy (SERS)-active hot-spot volumes by an array of 2D nano-superlenses |
| title_full | Generation of ultralarge Surface Enhanced Raman Spectroscopy (SERS)-active hot-spot volumes by an array of 2D nano-superlenses |
| title_fullStr | Generation of ultralarge Surface Enhanced Raman Spectroscopy (SERS)-active hot-spot volumes by an array of 2D nano-superlenses |
| title_full_unstemmed | Generation of ultralarge Surface Enhanced Raman Spectroscopy (SERS)-active hot-spot volumes by an array of 2D nano-superlenses |
| title_short | Generation of ultralarge Surface Enhanced Raman Spectroscopy (SERS)-active hot-spot volumes by an array of 2D nano-superlenses |
| title_sort | generation of ultralarge surface enhanced raman spectroscopy sers active hot spot volumes by an array of 2d nano superlenses |
| url | https://hdl.handle.net/10356/95978 http://hdl.handle.net/10220/10757 |
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