Copper-catalyzed aerobic intramolecular carbo- and amino-oxygenation of alkynes for synthesis of azaheterocycles
A synthetic method of highly substituted quinolines has been developed from N-(2-alkynylaryl)enamine carboxylates under Cu-catalyzed aerobic conditions via intramolecular carbo-oxygenation of alkynes. This strategy was further applied for N-alkynylamidines for amino-oxygenation of alkynes, leading t...
| Main Authors: | , , , , |
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| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
| Published: |
2013
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| Online Access: | https://hdl.handle.net/10356/96081 http://hdl.handle.net/10220/10603 |
| _version_ | 1811689509519097856 |
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| author | Toh, Kah Kah Sanjaya, Stephen Sahnoun, Sophian Chong, Sin Yee Chiba, Shunsuke |
| author2 | School of Physical and Mathematical Sciences |
| author_facet | School of Physical and Mathematical Sciences Toh, Kah Kah Sanjaya, Stephen Sahnoun, Sophian Chong, Sin Yee Chiba, Shunsuke |
| author_sort | Toh, Kah Kah |
| collection | NTU |
| description | A synthetic method of highly substituted quinolines has been developed from N-(2-alkynylaryl)enamine carboxylates under Cu-catalyzed aerobic conditions via intramolecular carbo-oxygenation of alkynes. This strategy was further applied for N-alkynylamidines for amino-oxygenation of alkynes, leading to imidazole and quinazoline derivatives. |
| first_indexed | 2024-10-01T05:49:14Z |
| format | Journal Article |
| id | ntu-10356/96081 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T05:49:14Z |
| publishDate | 2013 |
| record_format | dspace |
| spelling | ntu-10356/960812020-03-07T12:31:29Z Copper-catalyzed aerobic intramolecular carbo- and amino-oxygenation of alkynes for synthesis of azaheterocycles Toh, Kah Kah Sanjaya, Stephen Sahnoun, Sophian Chong, Sin Yee Chiba, Shunsuke School of Physical and Mathematical Sciences A synthetic method of highly substituted quinolines has been developed from N-(2-alkynylaryl)enamine carboxylates under Cu-catalyzed aerobic conditions via intramolecular carbo-oxygenation of alkynes. This strategy was further applied for N-alkynylamidines for amino-oxygenation of alkynes, leading to imidazole and quinazoline derivatives. 2013-06-25T03:46:18Z 2019-12-06T19:25:19Z 2013-06-25T03:46:18Z 2019-12-06T19:25:19Z 2012 2012 Journal Article Toh, K. K., Sanjaya, S., Sahnoun, S., Chong, S. Y., & Chiba, S. (2012). Copper-Catalyzed Aerobic Intramolecular Carbo- and Amino-Oxygenation of Alkynes for Synthesis of Azaheterocycles. Organic Letters, 14(9), 2290-2292. 1523-7060 https://hdl.handle.net/10356/96081 http://hdl.handle.net/10220/10603 10.1021/ol3007106 en Organic letters © 2012 American Chemical Society. |
| spellingShingle | Toh, Kah Kah Sanjaya, Stephen Sahnoun, Sophian Chong, Sin Yee Chiba, Shunsuke Copper-catalyzed aerobic intramolecular carbo- and amino-oxygenation of alkynes for synthesis of azaheterocycles |
| title | Copper-catalyzed aerobic intramolecular carbo- and amino-oxygenation of alkynes for synthesis of azaheterocycles |
| title_full | Copper-catalyzed aerobic intramolecular carbo- and amino-oxygenation of alkynes for synthesis of azaheterocycles |
| title_fullStr | Copper-catalyzed aerobic intramolecular carbo- and amino-oxygenation of alkynes for synthesis of azaheterocycles |
| title_full_unstemmed | Copper-catalyzed aerobic intramolecular carbo- and amino-oxygenation of alkynes for synthesis of azaheterocycles |
| title_short | Copper-catalyzed aerobic intramolecular carbo- and amino-oxygenation of alkynes for synthesis of azaheterocycles |
| title_sort | copper catalyzed aerobic intramolecular carbo and amino oxygenation of alkynes for synthesis of azaheterocycles |
| url | https://hdl.handle.net/10356/96081 http://hdl.handle.net/10220/10603 |
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