Diabetes mellitus : enquiry into its medical aspects and bioengineering of its monitoring and regulation
Diabetes mellitus (DM) or hyperglycemia (in a more generalized term, high blood sugar) is a metabolic disorder that is now highly prevalent in the world population. Most of the food that people consume is converted into glucose, which enters the bloodstream following absorption–assimilation mechanis...
| Main Authors: | , , , , , , , , , |
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| Format: | Journal Article |
| Language: | English |
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2013
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| Online Access: | https://hdl.handle.net/10356/96269 http://hdl.handle.net/10220/11487 |
| _version_ | 1811684403144818688 |
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| author | Acharya, U. Rajendra Ghista, Dhanjoo N. Nergui, Myagmarbayar Chattopadhyay, Subhagata Ng, Eddie Yin-Kwee Sree, Subbhuraam Vinitha Tong, Jasper W. K. Tan, Jen Hong Meng, Loh Kah Suri, Jasjit S. |
| author2 | School of Mechanical and Aerospace Engineering |
| author_facet | School of Mechanical and Aerospace Engineering Acharya, U. Rajendra Ghista, Dhanjoo N. Nergui, Myagmarbayar Chattopadhyay, Subhagata Ng, Eddie Yin-Kwee Sree, Subbhuraam Vinitha Tong, Jasper W. K. Tan, Jen Hong Meng, Loh Kah Suri, Jasjit S. |
| author_sort | Acharya, U. Rajendra |
| collection | NTU |
| description | Diabetes mellitus (DM) or hyperglycemia (in a more generalized term, high blood sugar) is a metabolic disorder that is now highly prevalent in the world population. Most of the food that people consume is converted into glucose, which enters the bloodstream following absorption–assimilation mechanisms. As a natural process, cells in our body utilize glucose for growth and energy. The glucose balance is maintained by a hormone called insulin that is secreted by the beta cells of pancreas. Hypotheses at the backdrop of DM occurrence are either (i) enough insulin is not produced and secreted resulting in increased level of glucose in blood, or (ii) insulin is insensitive to glucose, or (iii) insulin is non-targeted etc. If DM remains uncontrolled over time, it leads to serious damage to many of the body's systems, especially the nerves and blood vessels. This paper develops an enquiry into diabetes from many angles: (i) Diabetes as a disorder, its complications, causes, diagnostic tests, and treatment; (ii) Analysis of retinal and plantar images to characterize diabetes complications; (iii) How analysis of heart rate variability signals can depict diabetes; (iv) Biomedical engineering of the glucose–insulin regulatory system, and its employment in the modeling of the oral glucose tolerance test data, to detect diabetes as well as persons at risk of being diabetic; (v) Application of the glucose–insulin regulatory system to formulate an insulin delivery system for controlling blood sugar. |
| first_indexed | 2024-10-01T04:28:04Z |
| format | Journal Article |
| id | ntu-10356/96269 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T04:28:04Z |
| publishDate | 2013 |
| record_format | dspace |
| spelling | ntu-10356/962692020-03-07T13:22:15Z Diabetes mellitus : enquiry into its medical aspects and bioengineering of its monitoring and regulation Acharya, U. Rajendra Ghista, Dhanjoo N. Nergui, Myagmarbayar Chattopadhyay, Subhagata Ng, Eddie Yin-Kwee Sree, Subbhuraam Vinitha Tong, Jasper W. K. Tan, Jen Hong Meng, Loh Kah Suri, Jasjit S. School of Mechanical and Aerospace Engineering DRNTU::Engineering::Mechanical engineering Diabetes mellitus (DM) or hyperglycemia (in a more generalized term, high blood sugar) is a metabolic disorder that is now highly prevalent in the world population. Most of the food that people consume is converted into glucose, which enters the bloodstream following absorption–assimilation mechanisms. As a natural process, cells in our body utilize glucose for growth and energy. The glucose balance is maintained by a hormone called insulin that is secreted by the beta cells of pancreas. Hypotheses at the backdrop of DM occurrence are either (i) enough insulin is not produced and secreted resulting in increased level of glucose in blood, or (ii) insulin is insensitive to glucose, or (iii) insulin is non-targeted etc. If DM remains uncontrolled over time, it leads to serious damage to many of the body's systems, especially the nerves and blood vessels. This paper develops an enquiry into diabetes from many angles: (i) Diabetes as a disorder, its complications, causes, diagnostic tests, and treatment; (ii) Analysis of retinal and plantar images to characterize diabetes complications; (iii) How analysis of heart rate variability signals can depict diabetes; (iv) Biomedical engineering of the glucose–insulin regulatory system, and its employment in the modeling of the oral glucose tolerance test data, to detect diabetes as well as persons at risk of being diabetic; (v) Application of the glucose–insulin regulatory system to formulate an insulin delivery system for controlling blood sugar. 2013-07-16T01:42:06Z 2019-12-06T19:28:02Z 2013-07-16T01:42:06Z 2019-12-06T19:28:02Z 2012 2012 Journal Article Acharya, U. R., Ghiata, D. N., Nergui, M., Chattopadhyay, S., Ng, E. Y. K., Sree, S. V., et al. (2012). Diabetes mellitus : enquiry into its medical aspects and bioengineering of its monitoring and regulation. Journal of mechanics in medicine and biology, 12(01), 1230001-. https://hdl.handle.net/10356/96269 http://hdl.handle.net/10220/11487 10.1142/S0219519412004417 en Journal of mechanics in medicine and biology © 2012 World Scientific Publishing Company. |
| spellingShingle | DRNTU::Engineering::Mechanical engineering Acharya, U. Rajendra Ghista, Dhanjoo N. Nergui, Myagmarbayar Chattopadhyay, Subhagata Ng, Eddie Yin-Kwee Sree, Subbhuraam Vinitha Tong, Jasper W. K. Tan, Jen Hong Meng, Loh Kah Suri, Jasjit S. Diabetes mellitus : enquiry into its medical aspects and bioengineering of its monitoring and regulation |
| title | Diabetes mellitus : enquiry into its medical aspects and bioengineering of its monitoring and regulation |
| title_full | Diabetes mellitus : enquiry into its medical aspects and bioengineering of its monitoring and regulation |
| title_fullStr | Diabetes mellitus : enquiry into its medical aspects and bioengineering of its monitoring and regulation |
| title_full_unstemmed | Diabetes mellitus : enquiry into its medical aspects and bioengineering of its monitoring and regulation |
| title_short | Diabetes mellitus : enquiry into its medical aspects and bioengineering of its monitoring and regulation |
| title_sort | diabetes mellitus enquiry into its medical aspects and bioengineering of its monitoring and regulation |
| topic | DRNTU::Engineering::Mechanical engineering |
| url | https://hdl.handle.net/10356/96269 http://hdl.handle.net/10220/11487 |
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