The effect of threshold value on the architectural parameters and stiffness of human cancellous bone in micro ct analysis
In this study, the effects of threshold variation in image segmentation of micro CT images of cancellous bone in the determination of the architectural parameters and stiffness were investigated. A total of 42 samples of 6 × 6 × 6 mm3 cubes with threshold values set between 500–1100 greyscale in inc...
| Main Authors: | , , , , |
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| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
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2013
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| Online Access: | https://hdl.handle.net/10356/96286 http://hdl.handle.net/10220/11438 |
| _version_ | 1826114182300303360 |
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| author | Yan, Ya-Bo Qi, Wei Qiu, Tian-Xia Teo, Ee-Chon Lei, Wei |
| author2 | School of Mechanical and Aerospace Engineering |
| author_facet | School of Mechanical and Aerospace Engineering Yan, Ya-Bo Qi, Wei Qiu, Tian-Xia Teo, Ee-Chon Lei, Wei |
| author_sort | Yan, Ya-Bo |
| collection | NTU |
| description | In this study, the effects of threshold variation in image segmentation of micro CT images of cancellous bone in the determination of the architectural parameters and stiffness were investigated. A total of 42 samples of 6 × 6 × 6 mm3 cubes with threshold values set between 500–1100 greyscale in increment of 100 of CT images of six human C5 vertebral bodies were analyzed. Threshold value of 800, based on Otsu's method, was set for the control group. From various threshold values, the respective architectural parameters, and the corresponding stiffness in three orthotropic directions (Exx, Eyy, Ezz) of each cube were computed from the voxel-based micro-finite element models under compressive simulation. The results showed that 1% variation of threshold value resulted in a 3.4% variation in BV/TV, 2% in Tb.N, 3.1% in Tb.Th, 2.9% in BS/BV, 1.8% in Tb.Sp, 29.2% in Exx, 28.7% Eyy and 27.7% in Ezz. Statistical analysis showed that 2.9% threshold variation caused significant change in BV/TV, Tb.Th, Exx, Eyy and Ezz values. The study shows that with threshold variation of more than 2.9%, significant differences in the architectural parameters and stiffness compared to those based on Otsu's method. |
| first_indexed | 2024-10-01T03:35:18Z |
| format | Journal Article |
| id | ntu-10356/96286 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T03:35:18Z |
| publishDate | 2013 |
| record_format | dspace |
| spelling | ntu-10356/962862020-03-07T13:22:15Z The effect of threshold value on the architectural parameters and stiffness of human cancellous bone in micro ct analysis Yan, Ya-Bo Qi, Wei Qiu, Tian-Xia Teo, Ee-Chon Lei, Wei School of Mechanical and Aerospace Engineering DRNTU::Engineering::Mechanical engineering::Bio-mechatronics In this study, the effects of threshold variation in image segmentation of micro CT images of cancellous bone in the determination of the architectural parameters and stiffness were investigated. A total of 42 samples of 6 × 6 × 6 mm3 cubes with threshold values set between 500–1100 greyscale in increment of 100 of CT images of six human C5 vertebral bodies were analyzed. Threshold value of 800, based on Otsu's method, was set for the control group. From various threshold values, the respective architectural parameters, and the corresponding stiffness in three orthotropic directions (Exx, Eyy, Ezz) of each cube were computed from the voxel-based micro-finite element models under compressive simulation. The results showed that 1% variation of threshold value resulted in a 3.4% variation in BV/TV, 2% in Tb.N, 3.1% in Tb.Th, 2.9% in BS/BV, 1.8% in Tb.Sp, 29.2% in Exx, 28.7% Eyy and 27.7% in Ezz. Statistical analysis showed that 2.9% threshold variation caused significant change in BV/TV, Tb.Th, Exx, Eyy and Ezz values. The study shows that with threshold variation of more than 2.9%, significant differences in the architectural parameters and stiffness compared to those based on Otsu's method. 2013-07-15T07:12:43Z 2019-12-06T19:28:11Z 2013-07-15T07:12:43Z 2019-12-06T19:28:11Z 2012 2012 Journal Article Yan, Y.-B., Qi, W., Qiu, T.-X., Teo, E.-C., & Lei, W. (2012). The effect of threshold value on the architectural parameters and stiffness of human cancellous bone in micro ct analysis. Journal of Mechanics in Medicine and Biology, 12(05), 1250092-. https://hdl.handle.net/10356/96286 http://hdl.handle.net/10220/11438 10.1142/S0219519412500923 en Journal of mechanics in medicine and biology © 2012 World Scientific Publishing Co. |
| spellingShingle | DRNTU::Engineering::Mechanical engineering::Bio-mechatronics Yan, Ya-Bo Qi, Wei Qiu, Tian-Xia Teo, Ee-Chon Lei, Wei The effect of threshold value on the architectural parameters and stiffness of human cancellous bone in micro ct analysis |
| title | The effect of threshold value on the architectural parameters and stiffness of human cancellous bone in micro ct analysis |
| title_full | The effect of threshold value on the architectural parameters and stiffness of human cancellous bone in micro ct analysis |
| title_fullStr | The effect of threshold value on the architectural parameters and stiffness of human cancellous bone in micro ct analysis |
| title_full_unstemmed | The effect of threshold value on the architectural parameters and stiffness of human cancellous bone in micro ct analysis |
| title_short | The effect of threshold value on the architectural parameters and stiffness of human cancellous bone in micro ct analysis |
| title_sort | effect of threshold value on the architectural parameters and stiffness of human cancellous bone in micro ct analysis |
| topic | DRNTU::Engineering::Mechanical engineering::Bio-mechatronics |
| url | https://hdl.handle.net/10356/96286 http://hdl.handle.net/10220/11438 |
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