Towards in vivo intradermal surface enhanced Raman scattering (SERS) measurements: silver coated microneedle based SERS probe
We propose a microneedle coated with silver (Ag) to detect analytes at low concentrations positioned at a depth of more than 700 μm below the surface of a skin phantom with absorbers and scatterers for mimicking the intradermal surface-enhanced Raman scattering (SERS) measurements. The Ag layer in t...
| Main Authors: | , |
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| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
| Published: |
2013
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10356/96608 http://hdl.handle.net/10220/18057 |
| _version_ | 1811685307367555072 |
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| author | Yuen, Clement Liu, Quan |
| author2 | School of Chemical and Biomedical Engineering |
| author_facet | School of Chemical and Biomedical Engineering Yuen, Clement Liu, Quan |
| author_sort | Yuen, Clement |
| collection | NTU |
| description | We propose a microneedle coated with silver (Ag) to detect analytes at low concentrations positioned at a depth of more than 700 μm below the surface of a skin phantom with absorbers and scatterers for mimicking the intradermal surface-enhanced Raman scattering (SERS) measurements. The Ag layer in the Ag-coated microneedle-based probe is found to be the key to the effective detection of analytes buried inside the aforesaid phantom. Glucose concentrations ranging from 5 to 150 mM inside phantoms can be estimated with a root mean square error (RMSE) of 3.3 mM. This work shows the potential of using microneedles for simple in vivo intradermal SERS measurements of analytes with clinical relevance. |
| first_indexed | 2024-10-01T04:42:27Z |
| format | Journal Article |
| id | ntu-10356/96608 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T04:42:27Z |
| publishDate | 2013 |
| record_format | dspace |
| spelling | ntu-10356/966082020-03-07T11:35:37Z Towards in vivo intradermal surface enhanced Raman scattering (SERS) measurements: silver coated microneedle based SERS probe Yuen, Clement Liu, Quan School of Chemical and Biomedical Engineering DRNTU::Science::Chemistry::Biochemistry We propose a microneedle coated with silver (Ag) to detect analytes at low concentrations positioned at a depth of more than 700 μm below the surface of a skin phantom with absorbers and scatterers for mimicking the intradermal surface-enhanced Raman scattering (SERS) measurements. The Ag layer in the Ag-coated microneedle-based probe is found to be the key to the effective detection of analytes buried inside the aforesaid phantom. Glucose concentrations ranging from 5 to 150 mM inside phantoms can be estimated with a root mean square error (RMSE) of 3.3 mM. This work shows the potential of using microneedles for simple in vivo intradermal SERS measurements of analytes with clinical relevance. 2013-12-05T02:10:32Z 2019-12-06T19:32:58Z 2013-12-05T02:10:32Z 2019-12-06T19:32:58Z 2013 2013 Journal Article Yuen, C., & Liu, Q. (2013). Towards in vivo intradermal surface enhanced Raman scattering (SERS) measurements: silver coated microneedle based SERS probe. Journal of biophotonics, 7(9), 683-689. 1864-063X https://hdl.handle.net/10356/96608 http://hdl.handle.net/10220/18057 10.1002/jbio.201300006 en Journal of biophotonics © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. |
| spellingShingle | DRNTU::Science::Chemistry::Biochemistry Yuen, Clement Liu, Quan Towards in vivo intradermal surface enhanced Raman scattering (SERS) measurements: silver coated microneedle based SERS probe |
| title | Towards in vivo intradermal surface enhanced Raman scattering (SERS) measurements: silver coated microneedle based SERS probe |
| title_full | Towards in vivo intradermal surface enhanced Raman scattering (SERS) measurements: silver coated microneedle based SERS probe |
| title_fullStr | Towards in vivo intradermal surface enhanced Raman scattering (SERS) measurements: silver coated microneedle based SERS probe |
| title_full_unstemmed | Towards in vivo intradermal surface enhanced Raman scattering (SERS) measurements: silver coated microneedle based SERS probe |
| title_short | Towards in vivo intradermal surface enhanced Raman scattering (SERS) measurements: silver coated microneedle based SERS probe |
| title_sort | towards in vivo intradermal surface enhanced raman scattering sers measurements silver coated microneedle based sers probe |
| topic | DRNTU::Science::Chemistry::Biochemistry |
| url | https://hdl.handle.net/10356/96608 http://hdl.handle.net/10220/18057 |
| work_keys_str_mv | AT yuenclement towardsinvivointradermalsurfaceenhancedramanscatteringsersmeasurementssilvercoatedmicroneedlebasedsersprobe AT liuquan towardsinvivointradermalsurfaceenhancedramanscatteringsersmeasurementssilvercoatedmicroneedlebasedsersprobe |