Chapter fourteen – the mechanisms of Mg2+ and Co2+ transport by the CorA family of divalent cation transporters
The metal ions Mg2+ and Co2+ are essential for life, although to different degree. They have similar chemical and physical properties, but their slight differences result in Mg2+ to be the most abundant metal ion in living cells and the trace element Co2+ being toxic at relatively low concentrations...
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| Format: | Journal Article |
| Language: | English |
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2013
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| Online Access: | https://hdl.handle.net/10356/96836 http://hdl.handle.net/10220/13200 http://www.sciencedirect.com/science/article/pii/B9780123943903000148 |
| _version_ | 1826111257595346944 |
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| author | Guskov, Albert Eshaghi, Said |
| author2 | School of Biological Sciences |
| author_facet | School of Biological Sciences Guskov, Albert Eshaghi, Said |
| author_sort | Guskov, Albert |
| collection | NTU |
| description | The metal ions Mg2+ and Co2+ are essential for life, although to different degree. They have similar chemical and physical properties, but their slight differences result in Mg2+ to be the most abundant metal ion in living cells and the trace element Co2+ being toxic at relatively low concentrations. Specialized transporters have evolved in living cells to supply and balance the Mg2+ and Co2+ need of the cells. The current knowledge of the molecular mechanisms of Mg2+ and Co2+ -specific transporters is very limited at this point. Recently, there has been remarkable advances to understand the CorA family, a family of transporters that are able to transport both ions. These new data have increased our insights in how Mg2+ and Co2+ are translocated across membranes. Presently, CorA is probably the best system to study the mechanisms of Mg2+ and Co2+ transport. This chapter discusses the mechanisms through which CorA selects, transports, and regulates the translocation of its substrate. In addition, we highlight the physical and chemical properties of the substrates, which are important parameters required for better understanding of the transporter action. |
| first_indexed | 2024-10-01T02:47:43Z |
| format | Journal Article |
| id | ntu-10356/96836 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T02:47:43Z |
| publishDate | 2013 |
| record_format | dspace |
| spelling | ntu-10356/968362019-12-06T19:35:35Z Chapter fourteen – the mechanisms of Mg2+ and Co2+ transport by the CorA family of divalent cation transporters Guskov, Albert Eshaghi, Said School of Biological Sciences DRNTU::Science::Biological sciences The metal ions Mg2+ and Co2+ are essential for life, although to different degree. They have similar chemical and physical properties, but their slight differences result in Mg2+ to be the most abundant metal ion in living cells and the trace element Co2+ being toxic at relatively low concentrations. Specialized transporters have evolved in living cells to supply and balance the Mg2+ and Co2+ need of the cells. The current knowledge of the molecular mechanisms of Mg2+ and Co2+ -specific transporters is very limited at this point. Recently, there has been remarkable advances to understand the CorA family, a family of transporters that are able to transport both ions. These new data have increased our insights in how Mg2+ and Co2+ are translocated across membranes. Presently, CorA is probably the best system to study the mechanisms of Mg2+ and Co2+ transport. This chapter discusses the mechanisms through which CorA selects, transports, and regulates the translocation of its substrate. In addition, we highlight the physical and chemical properties of the substrates, which are important parameters required for better understanding of the transporter action. 2013-08-23T03:40:01Z 2019-12-06T19:35:35Z 2013-08-23T03:40:01Z 2019-12-06T19:35:35Z 2012 2012 Journal Article https://hdl.handle.net/10356/96836 http://hdl.handle.net/10220/13200 http://www.sciencedirect.com/science/article/pii/B9780123943903000148 en Current topics in membranes |
| spellingShingle | DRNTU::Science::Biological sciences Guskov, Albert Eshaghi, Said Chapter fourteen – the mechanisms of Mg2+ and Co2+ transport by the CorA family of divalent cation transporters |
| title | Chapter fourteen – the mechanisms of Mg2+ and Co2+ transport by the CorA family of divalent cation transporters |
| title_full | Chapter fourteen – the mechanisms of Mg2+ and Co2+ transport by the CorA family of divalent cation transporters |
| title_fullStr | Chapter fourteen – the mechanisms of Mg2+ and Co2+ transport by the CorA family of divalent cation transporters |
| title_full_unstemmed | Chapter fourteen – the mechanisms of Mg2+ and Co2+ transport by the CorA family of divalent cation transporters |
| title_short | Chapter fourteen – the mechanisms of Mg2+ and Co2+ transport by the CorA family of divalent cation transporters |
| title_sort | chapter fourteen the mechanisms of mg2 and co2 transport by the cora family of divalent cation transporters |
| topic | DRNTU::Science::Biological sciences |
| url | https://hdl.handle.net/10356/96836 http://hdl.handle.net/10220/13200 http://www.sciencedirect.com/science/article/pii/B9780123943903000148 |
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