Cationic peptidopolysaccharides show excellent broad-spectrum antimicrobial activities and high selectivity
Facilely synthesized cationic peptidopolysaccharides, which have a bacterial peptidoglycan-mimetic structure, show outstanding broad-spectrum activities against clinically significant bacteria and fungi and low mammalian cytotoxicity. Their structural affinity with microbial cell-wall constituents p...
| Main Authors: | , , , , , , , |
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| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
| Published: |
2013
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| Online Access: | https://hdl.handle.net/10356/97275 http://hdl.handle.net/10220/10456 |
| _version_ | 1826127076121378816 |
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| author | Hammond, Paula T. Chan-Park, Mary B. Li, Peng Rayatpisheh, Shahrzad Zhou, Chuncai Ye, Kai Poon, Yin Fun Duan, Hongwei |
| author2 | School of Chemical and Biomedical Engineering |
| author_facet | School of Chemical and Biomedical Engineering Hammond, Paula T. Chan-Park, Mary B. Li, Peng Rayatpisheh, Shahrzad Zhou, Chuncai Ye, Kai Poon, Yin Fun Duan, Hongwei |
| author_sort | Hammond, Paula T. |
| collection | NTU |
| description | Facilely synthesized cationic peptidopolysaccharides, which have a bacterial peptidoglycan-mimetic structure, show outstanding broad-spectrum activities against clinically significant bacteria and fungi and low mammalian cytotoxicity. Their structural affinity with microbial cell-wall constituents promotes penetration to reach the cytoplasmic membrane resulting in excellent antimicrobial activity and high selectivity. |
| first_indexed | 2024-10-01T07:02:51Z |
| format | Journal Article |
| id | ntu-10356/97275 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T07:02:51Z |
| publishDate | 2013 |
| record_format | dspace |
| spelling | ntu-10356/972752020-03-07T11:35:37Z Cationic peptidopolysaccharides show excellent broad-spectrum antimicrobial activities and high selectivity Hammond, Paula T. Chan-Park, Mary B. Li, Peng Rayatpisheh, Shahrzad Zhou, Chuncai Ye, Kai Poon, Yin Fun Duan, Hongwei School of Chemical and Biomedical Engineering Facilely synthesized cationic peptidopolysaccharides, which have a bacterial peptidoglycan-mimetic structure, show outstanding broad-spectrum activities against clinically significant bacteria and fungi and low mammalian cytotoxicity. Their structural affinity with microbial cell-wall constituents promotes penetration to reach the cytoplasmic membrane resulting in excellent antimicrobial activity and high selectivity. 2013-06-17T07:08:24Z 2019-12-06T19:40:49Z 2013-06-17T07:08:24Z 2019-12-06T19:40:49Z 2012 2012 Journal Article Li, P., Zhou, C., Rayatpisheh, S., Ye, K., Poon, Y. F., Hammond, P. T., et al. (2012). Cationic Peptidopolysaccharides Show Excellent Broad-Spectrum Antimicrobial Activities and High Selectivity. Advanced Materials, 24(30), 4130-4137. 1521-4095 https://hdl.handle.net/10356/97275 http://hdl.handle.net/10220/10456 10.1002/adma.201104186 en Advanced materials © 2012 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim. |
| spellingShingle | Hammond, Paula T. Chan-Park, Mary B. Li, Peng Rayatpisheh, Shahrzad Zhou, Chuncai Ye, Kai Poon, Yin Fun Duan, Hongwei Cationic peptidopolysaccharides show excellent broad-spectrum antimicrobial activities and high selectivity |
| title | Cationic peptidopolysaccharides show excellent broad-spectrum antimicrobial activities and high selectivity |
| title_full | Cationic peptidopolysaccharides show excellent broad-spectrum antimicrobial activities and high selectivity |
| title_fullStr | Cationic peptidopolysaccharides show excellent broad-spectrum antimicrobial activities and high selectivity |
| title_full_unstemmed | Cationic peptidopolysaccharides show excellent broad-spectrum antimicrobial activities and high selectivity |
| title_short | Cationic peptidopolysaccharides show excellent broad-spectrum antimicrobial activities and high selectivity |
| title_sort | cationic peptidopolysaccharides show excellent broad spectrum antimicrobial activities and high selectivity |
| url | https://hdl.handle.net/10356/97275 http://hdl.handle.net/10220/10456 |
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