Bioconjugated pluronic triblock-copolymer Micelle-encapsulated quantum dots for targeted imaging of cancer : in vitro and in vivo studies
Early in this study, CdTe/ZnS core/shell quantum dots (QDs) were encapsulated in carboxylated Pluronic F127 triblock polymeric micelle, to preserve the optical and colloidal stability of QDs in biological fluids. Folic acid (FA) was then conjugated to the surface of QDs for the targeted delivery of...
| Main Authors: | , , , , , , , , , |
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| Format: | Journal Article |
| Language: | English |
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2013
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| Online Access: | https://hdl.handle.net/10356/97423 http://hdl.handle.net/10220/11854 |
| _version_ | 1826120509636476928 |
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| author | Prasad, Paras N. Liu, Liwei Yong, Ken-Tye Roy, Indrajit Law, Wing-Cheung Ye, Ling Liu, Jianwei Liu, Jing Kumar, Rajiv Zhang, Xihe |
| author2 | School of Electrical and Electronic Engineering |
| author_facet | School of Electrical and Electronic Engineering Prasad, Paras N. Liu, Liwei Yong, Ken-Tye Roy, Indrajit Law, Wing-Cheung Ye, Ling Liu, Jianwei Liu, Jing Kumar, Rajiv Zhang, Xihe |
| author_sort | Prasad, Paras N. |
| collection | NTU |
| description | Early in this study, CdTe/ZnS core/shell quantum dots (QDs) were encapsulated in carboxylated Pluronic F127 triblock polymeric micelle, to preserve the optical and colloidal stability of QDs in biological fluids. Folic acid (FA) was then conjugated to the surface of QDs for the targeted delivery of the QD formulation to the tumor site, by exploiting the overexpressed FA receptors (FARs) on the tumor cells. Cytotoxicity study demonstrated that the QD formulation has negligible in vitro toxicity. The in vitro study showed that the bioconjugated micelle-encapsulated QDs, but not the unconjugated QDs, were able to efficiently label Panc-1 cancer cells. In vivo imaging study showed that bioconjugated QDs were able to target tumor site after intravenous injection of the formulation in tumor-bearing mice. |
| first_indexed | 2024-10-01T05:17:37Z |
| format | Journal Article |
| id | ntu-10356/97423 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T05:17:37Z |
| publishDate | 2013 |
| record_format | dspace |
| spelling | ntu-10356/974232022-02-16T16:28:56Z Bioconjugated pluronic triblock-copolymer Micelle-encapsulated quantum dots for targeted imaging of cancer : in vitro and in vivo studies Prasad, Paras N. Liu, Liwei Yong, Ken-Tye Roy, Indrajit Law, Wing-Cheung Ye, Ling Liu, Jianwei Liu, Jing Kumar, Rajiv Zhang, Xihe School of Electrical and Electronic Engineering DRNTU::Engineering::Electrical and electronic engineering Early in this study, CdTe/ZnS core/shell quantum dots (QDs) were encapsulated in carboxylated Pluronic F127 triblock polymeric micelle, to preserve the optical and colloidal stability of QDs in biological fluids. Folic acid (FA) was then conjugated to the surface of QDs for the targeted delivery of the QD formulation to the tumor site, by exploiting the overexpressed FA receptors (FARs) on the tumor cells. Cytotoxicity study demonstrated that the QD formulation has negligible in vitro toxicity. The in vitro study showed that the bioconjugated micelle-encapsulated QDs, but not the unconjugated QDs, were able to efficiently label Panc-1 cancer cells. In vivo imaging study showed that bioconjugated QDs were able to target tumor site after intravenous injection of the formulation in tumor-bearing mice. Published Version 2013-07-18T03:59:57Z 2019-12-06T19:42:37Z 2013-07-18T03:59:57Z 2019-12-06T19:42:37Z 2012 2012 Journal Article Liu, L., Yong, K.-T., Roy, I., Law, W.-C., Ye, L., Liu, J., et al. (2012). Bioconjugated Pluronic Triblock-Copolymer Micelle-Encapsulated Quantum Dots for Targeted Imaging of Cancer: In Vitro and In Vivo Studies. Theranostics, 2(7), 705-713. 1838-7640 https://hdl.handle.net/10356/97423 http://hdl.handle.net/10220/11854 10.7150/thno.3456 22896772 en Theranostics © 2012 Ivyspring International Publisher. This is an open-access article distributed under the terms of the Creative Commons License (http://creativecommons.org/ licenses/by-nc-nd/3.0/). Reproduction is permitted for personal, noncommercial use, provided that the article is in whole, unmodified, and properly cited. application/pdf |
| spellingShingle | DRNTU::Engineering::Electrical and electronic engineering Prasad, Paras N. Liu, Liwei Yong, Ken-Tye Roy, Indrajit Law, Wing-Cheung Ye, Ling Liu, Jianwei Liu, Jing Kumar, Rajiv Zhang, Xihe Bioconjugated pluronic triblock-copolymer Micelle-encapsulated quantum dots for targeted imaging of cancer : in vitro and in vivo studies |
| title | Bioconjugated pluronic triblock-copolymer Micelle-encapsulated quantum dots for targeted imaging of cancer : in vitro and in vivo studies |
| title_full | Bioconjugated pluronic triblock-copolymer Micelle-encapsulated quantum dots for targeted imaging of cancer : in vitro and in vivo studies |
| title_fullStr | Bioconjugated pluronic triblock-copolymer Micelle-encapsulated quantum dots for targeted imaging of cancer : in vitro and in vivo studies |
| title_full_unstemmed | Bioconjugated pluronic triblock-copolymer Micelle-encapsulated quantum dots for targeted imaging of cancer : in vitro and in vivo studies |
| title_short | Bioconjugated pluronic triblock-copolymer Micelle-encapsulated quantum dots for targeted imaging of cancer : in vitro and in vivo studies |
| title_sort | bioconjugated pluronic triblock copolymer micelle encapsulated quantum dots for targeted imaging of cancer in vitro and in vivo studies |
| topic | DRNTU::Engineering::Electrical and electronic engineering |
| url | https://hdl.handle.net/10356/97423 http://hdl.handle.net/10220/11854 |
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