Multi-harmonic homodyne approach for optical property measurement of turbid medium in transmission geometry
The accurate determination of both absorption and scattering properties in homogeneous diffuse medium is critical in many applications of diffuse optical imaging, especially in clinical applications such as breast cancer diagnosis. In this paper, we report a frequency-domain method to simultaneously...
| Main Authors: | , , , |
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| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
| Published: |
2013
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| Online Access: | https://hdl.handle.net/10356/97489 http://hdl.handle.net/10220/10589 |
| _version_ | 1826122858115366912 |
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| author | Ho, Jun Hui Chin, Hooi Ling Dong, Jing Lee, Kijoon |
| author2 | School of Chemical and Biomedical Engineering |
| author_facet | School of Chemical and Biomedical Engineering Ho, Jun Hui Chin, Hooi Ling Dong, Jing Lee, Kijoon |
| author_sort | Ho, Jun Hui |
| collection | NTU |
| description | The accurate determination of both absorption and scattering properties in homogeneous diffuse medium is critical in many applications of diffuse optical imaging, especially in clinical applications such as breast cancer diagnosis. In this paper, we report a frequency-domain method to simultaneously measure both absorption and reduced scattering coefficients (μa and μs′) in transmission geometry, based on a parallel homodyne approach using a RF-modulated laser source and a gain-modulated image intensifier. This method enables fast multi-pixel phase-sensitive measurement, which leads to an efficient way to obtain μa and μs′ values via the well-known analytical Green's function solution in slab geometry. We developed an approximate formula of the analytical solution that is especially suitable for multi-pixel data analysis. In addition, we present a comprehensive multi-harmonic data analysis that includes DC data, which offers multi-frequency information from a single-frequency dataset, hence leading to improved accuracy and stability in measurement. |
| first_indexed | 2024-10-01T05:55:06Z |
| format | Journal Article |
| id | ntu-10356/97489 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T05:55:06Z |
| publishDate | 2013 |
| record_format | dspace |
| spelling | ntu-10356/974892020-03-07T11:35:37Z Multi-harmonic homodyne approach for optical property measurement of turbid medium in transmission geometry Ho, Jun Hui Chin, Hooi Ling Dong, Jing Lee, Kijoon School of Chemical and Biomedical Engineering The accurate determination of both absorption and scattering properties in homogeneous diffuse medium is critical in many applications of diffuse optical imaging, especially in clinical applications such as breast cancer diagnosis. In this paper, we report a frequency-domain method to simultaneously measure both absorption and reduced scattering coefficients (μa and μs′) in transmission geometry, based on a parallel homodyne approach using a RF-modulated laser source and a gain-modulated image intensifier. This method enables fast multi-pixel phase-sensitive measurement, which leads to an efficient way to obtain μa and μs′ values via the well-known analytical Green's function solution in slab geometry. We developed an approximate formula of the analytical solution that is especially suitable for multi-pixel data analysis. In addition, we present a comprehensive multi-harmonic data analysis that includes DC data, which offers multi-frequency information from a single-frequency dataset, hence leading to improved accuracy and stability in measurement. 2013-06-25T03:01:57Z 2019-12-06T19:43:15Z 2013-06-25T03:01:57Z 2019-12-06T19:43:15Z 2011 2011 Journal Article Ho, J. H., Chin, H. L., Dong, J., & Lee, K. (2012). Multi-Harmonic homodyne approach for optical property measurement of turbid medium in transmission geometry. Optics Communications, 285(7), 2007-2011. 0030-4018 https://hdl.handle.net/10356/97489 http://hdl.handle.net/10220/10589 10.1016/j.optcom.2011.12.018 en Optics communications © 2011 Elsevier B.V. |
| spellingShingle | Ho, Jun Hui Chin, Hooi Ling Dong, Jing Lee, Kijoon Multi-harmonic homodyne approach for optical property measurement of turbid medium in transmission geometry |
| title | Multi-harmonic homodyne approach for optical property measurement of turbid medium in transmission geometry |
| title_full | Multi-harmonic homodyne approach for optical property measurement of turbid medium in transmission geometry |
| title_fullStr | Multi-harmonic homodyne approach for optical property measurement of turbid medium in transmission geometry |
| title_full_unstemmed | Multi-harmonic homodyne approach for optical property measurement of turbid medium in transmission geometry |
| title_short | Multi-harmonic homodyne approach for optical property measurement of turbid medium in transmission geometry |
| title_sort | multi harmonic homodyne approach for optical property measurement of turbid medium in transmission geometry |
| url | https://hdl.handle.net/10356/97489 http://hdl.handle.net/10220/10589 |
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