Palladium-catalyzed aerobic oxidative cyclization of N-aryl imines : indole synthesis from anilines and ketones
We report here an operationally simple, palladium-catalyzed cyclization reaction of N-aryl imines, affording indoles via the oxidative linkage of two C–H bonds under mild conditions using molecular oxygen as the sole oxidant. The process allows quick and atom-economical assembly of indole rings from...
| Main Authors: | , , |
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| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
| Published: |
2013
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| Online Access: | https://hdl.handle.net/10356/97583 http://hdl.handle.net/10220/11236 |
| _version_ | 1826114681367953408 |
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| author | Wei, Ye Deb, Indubhusan Yoshikai, Naohiko |
| author2 | School of Physical and Mathematical Sciences |
| author_facet | School of Physical and Mathematical Sciences Wei, Ye Deb, Indubhusan Yoshikai, Naohiko |
| author_sort | Wei, Ye |
| collection | NTU |
| description | We report here an operationally simple, palladium-catalyzed cyclization reaction of N-aryl imines, affording indoles via the oxidative linkage of two C–H bonds under mild conditions using molecular oxygen as the sole oxidant. The process allows quick and atom-economical assembly of indole rings from inexpensive and readily available anilines and ketones and tolerates a broad range of functional groups. |
| first_indexed | 2024-10-01T03:43:26Z |
| format | Journal Article |
| id | ntu-10356/97583 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T03:43:26Z |
| publishDate | 2013 |
| record_format | dspace |
| spelling | ntu-10356/975832020-03-07T12:34:44Z Palladium-catalyzed aerobic oxidative cyclization of N-aryl imines : indole synthesis from anilines and ketones Wei, Ye Deb, Indubhusan Yoshikai, Naohiko School of Physical and Mathematical Sciences We report here an operationally simple, palladium-catalyzed cyclization reaction of N-aryl imines, affording indoles via the oxidative linkage of two C–H bonds under mild conditions using molecular oxygen as the sole oxidant. The process allows quick and atom-economical assembly of indole rings from inexpensive and readily available anilines and ketones and tolerates a broad range of functional groups. 2013-07-11T08:17:13Z 2019-12-06T19:44:18Z 2013-07-11T08:17:13Z 2019-12-06T19:44:18Z 2012 2012 Journal Article Wei, Y., Deb, I., & Yoshikai, N. (2012). Palladium-Catalyzed Aerobic Oxidative Cyclization of N-Aryl Imines: Indole Synthesis from Anilines and Ketones. Journal of the American Chemical Society, 134(22), 9098-9101. https://hdl.handle.net/10356/97583 http://hdl.handle.net/10220/11236 10.1021/ja3030824 en Journal of the American chemical society © 2012 American Chemical Society. |
| spellingShingle | Wei, Ye Deb, Indubhusan Yoshikai, Naohiko Palladium-catalyzed aerobic oxidative cyclization of N-aryl imines : indole synthesis from anilines and ketones |
| title | Palladium-catalyzed aerobic oxidative cyclization of N-aryl imines : indole synthesis from anilines and ketones |
| title_full | Palladium-catalyzed aerobic oxidative cyclization of N-aryl imines : indole synthesis from anilines and ketones |
| title_fullStr | Palladium-catalyzed aerobic oxidative cyclization of N-aryl imines : indole synthesis from anilines and ketones |
| title_full_unstemmed | Palladium-catalyzed aerobic oxidative cyclization of N-aryl imines : indole synthesis from anilines and ketones |
| title_short | Palladium-catalyzed aerobic oxidative cyclization of N-aryl imines : indole synthesis from anilines and ketones |
| title_sort | palladium catalyzed aerobic oxidative cyclization of n aryl imines indole synthesis from anilines and ketones |
| url | https://hdl.handle.net/10356/97583 http://hdl.handle.net/10220/11236 |
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