Modelling chromatin structure and dynamics : status and prospects
The packaging of genomic DNA into chromatin in the eukaryotic cell nucleus demands extensive compaction. This requires attractive nucleosome–nucleosome interactions to overcome repulsion between the negatively charged DNA segments as well as other constraints. At the same time, DNA must be dynamical...
| Main Authors: | , , , |
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| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
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2013
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| Online Access: | https://hdl.handle.net/10356/97584 http://hdl.handle.net/10220/13197 |
| _version_ | 1811694267166359552 |
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| author | Korolev, Nikolay Fan, Yanping Nordenskiöld, Lars Lyubartsev, Alexander P. |
| author2 | School of Biological Sciences |
| author_facet | School of Biological Sciences Korolev, Nikolay Fan, Yanping Nordenskiöld, Lars Lyubartsev, Alexander P. |
| author_sort | Korolev, Nikolay |
| collection | NTU |
| description | The packaging of genomic DNA into chromatin in the eukaryotic cell nucleus demands extensive compaction. This requires attractive nucleosome–nucleosome interactions to overcome repulsion between the negatively charged DNA segments as well as other constraints. At the same time, DNA must be dynamically accessible to the cellular machinery that operates on it. Recent progress in the experimental characterisation of the higher order structure and dynamics of well-defined chromatin fibres has stimulated the attempts at theoretical description of chromatin and the nucleosome. Here we review the present status of chromatin modelling, with particular emphasis on coarse-grained computer simulation models, the role of electrostatic interactions, and discuss future perspectives in the field. |
| first_indexed | 2024-10-01T07:04:51Z |
| format | Journal Article |
| id | ntu-10356/97584 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T07:04:51Z |
| publishDate | 2013 |
| record_format | dspace |
| spelling | ntu-10356/975842020-03-07T12:18:19Z Modelling chromatin structure and dynamics : status and prospects Korolev, Nikolay Fan, Yanping Nordenskiöld, Lars Lyubartsev, Alexander P. School of Biological Sciences DRNTU::Science::Biological sciences The packaging of genomic DNA into chromatin in the eukaryotic cell nucleus demands extensive compaction. This requires attractive nucleosome–nucleosome interactions to overcome repulsion between the negatively charged DNA segments as well as other constraints. At the same time, DNA must be dynamically accessible to the cellular machinery that operates on it. Recent progress in the experimental characterisation of the higher order structure and dynamics of well-defined chromatin fibres has stimulated the attempts at theoretical description of chromatin and the nucleosome. Here we review the present status of chromatin modelling, with particular emphasis on coarse-grained computer simulation models, the role of electrostatic interactions, and discuss future perspectives in the field. 2013-08-23T03:33:09Z 2019-12-06T19:44:19Z 2013-08-23T03:33:09Z 2019-12-06T19:44:19Z 2012 2012 Journal Article Korolev, N., Fan, Y., Lyubartsev, A. P.,& Nordenskiöld, L. (2012). Modelling chromatin structure and dynamics: status and prospects. Current Opinion in Structural Biology, 22(2), 151-159. https://hdl.handle.net/10356/97584 http://hdl.handle.net/10220/13197 10.1016/j.sbi.2012.01.006 en Current opinion in structural biology |
| spellingShingle | DRNTU::Science::Biological sciences Korolev, Nikolay Fan, Yanping Nordenskiöld, Lars Lyubartsev, Alexander P. Modelling chromatin structure and dynamics : status and prospects |
| title | Modelling chromatin structure and dynamics : status and prospects |
| title_full | Modelling chromatin structure and dynamics : status and prospects |
| title_fullStr | Modelling chromatin structure and dynamics : status and prospects |
| title_full_unstemmed | Modelling chromatin structure and dynamics : status and prospects |
| title_short | Modelling chromatin structure and dynamics : status and prospects |
| title_sort | modelling chromatin structure and dynamics status and prospects |
| topic | DRNTU::Science::Biological sciences |
| url | https://hdl.handle.net/10356/97584 http://hdl.handle.net/10220/13197 |
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